Wi-Fi decreases melatonin protective effect and increases hippocampal neuronal damage in pentylenetetrazole induced model seizures in rats

Akkaya, Recep; Gümüş, Erkan; Akkaya, Birnur; Karabulut, Sebahattin; Gülmez, Kader; Karademir, Mustafa; Taştemur, Yaşar; Taşkıran, Ahmet Şevki

doi:10.1016/j.pathophys.2019.11.003

Cited by 17 publications

(19 citation statements)

References 37 publications

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“…As peroxynitrite exerts its cytotoxic action thru mitophagy, inhibiting peroxynitritemediated mitophagy activation improves ischemia reperfusion injury [37,38]. Moreover, melatonin as an antioxidant improves TOS, TAS, OSI, and peroxynitrite, as demonstrated in previous studies [39][40][41].…”

Section: Discussionsupporting

confidence: 55%

Melatonin attenuates ovarian ischemia reperfusion injury in rats by decreasing oxidative stress index and peroxynitrite

Kalyoncu¹,

Yılmaz²,

Demır³

et al. 2020

Turk J Med Sci

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Background/aim: To evaluate the protective effect of melatonin on ovarian ischemia reperfusion injury in a rat model. Materials and methods: Forty-eight rats were separated equally into 6 groups. Group 1: sham; Group 2: surgical control with 3-h bilateral ovarian torsion and detorsion; Group 3: intraperitoneal 5% ethanol (1 mL) just after detorsion (as melatonin was dissolved in ethanol); Group 4: 10 mg/kg intraperitoneal melatonin 30 min before 3-h torsion; Group 5:10 mg/kg intraperitoneal melatonin just after detorsion; Group 6:10 mg/kg intraperitoneal melatonin 30 min before torsion and just after detorsion. Both ovaries and blood samples were obtained 7 days after detorsion for histopathological and biochemical analysis.Results: In Group 1, serum levels of total oxidant status (TOS) (μmol H2O2 equivalent/g wet tissue)were significantly lower than in Group2 (P = 0.0023), while tissue TOS levels were lower than in Group 3 (P = 0.0030). Similarly, serum and tissue levels of peroxynitrite in Group 6were significantly lower than those ofGroup 2 (P = 0.0023 and P = 0.040, respectively). Moreover, serum oxidative stress index (OSI) (arbitrary unit) levels were significantly increased in Group 2 when compared to groups 1 and 6 (P = 0.0023 and P= 0.0016, respectively) and in Group 3 with respect to groups 1, 4, 5, and 6 (P = 0.0023, P = 0.0026, P = 0.0008, and P = 0.0011, respectively). Furthermore, there was a significant decrease in histopathological scores including follicular degeneration, vascular congestion, hemorrhage, and inflammation in the melatonin and sham groups in comparison with control groups. Additionally, primordial follicle count was significantly higher in Group 6 than in Group 2 (P = 0.0002).Conclusion: Melatonin attenuates ischemia reperfusion damage in a rat torsion/detorsion model by improving histopathological and biochemical findings including OSI and peroxynitrite.

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Section: Discussionsupporting

confidence: 55%

Melatonin attenuates ovarian ischemia reperfusion injury in rats by decreasing oxidative stress index and peroxynitrite

Kalyoncu¹,

Yılmaz²,

Demır³

et al. 2020

Turk J Med Sci

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“…In the study, it was seen that melatonin (antioxidant activity) effect was decreased in rat kidney tissues exposed to Wi-Fi effect 9 . The antioxidant effect is reduced by Wi-Fi causing cellular damage 9,18 . In this study, the melatonin effect of Wi-Fi waves was evaluated with TAS, TOS and OSI values obtained from kidney tissue.…”

Section: Introductionmentioning

confidence: 94%

“…Some of these studies indicated that the effects of electromagnetic waves on living organisms were important 7 , while some of them had reported no significant effects 8 . New generation wireless communication technologies rapidly increase the levels of electromagnetic pollution in the world 9 . As is known, the same electric field in the environment even if it is increasing in frequency dependent conductivity of living tissues.…”

Section: Introductionmentioning

confidence: 99%

“…Antioxidants help cells in the destruction of free radicals 17 . Melatonin is a powerful antioxidant and more potent than other known antioxidants 9 . In the study, it was seen that melatonin (antioxidant activity) effect was decreased in rat kidney tissues exposed to Wi-Fi effect 9 .…”

Section: Introductionmentioning

confidence: 99%

“…Melatonin is a powerful antioxidant and more potent than other known antioxidants 9 . In the study, it was seen that melatonin (antioxidant activity) effect was decreased in rat kidney tissues exposed to Wi-Fi effect 9 . The antioxidant effect is reduced by Wi-Fi causing cellular damage 9,18 .…”

Section: Introductionmentioning

confidence: 99%

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The effect of Wireless (Wi-Fi) electromagnetic fields on oxidative stress in rat kidney tissues: A biophysical analysis

Akkaya¹

2020

Cumhuriyet Medical Journal

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The aim is to investigate the effect of melatonin on oxidative damage in rats exposed to Wi-Fi. This study aims to evaluate the effects of Wriless waves biophysically and biochemically. This study was to investigate the effects of Wi-Fi electromagnetic field (Wi-Fi-EMF) on total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) in various rat tissues. In this study, we used 30 male Wistar Albino rats of 230-250 grams of body weight. Animals were divided into five groups as control, saline (1 ml/kg/day olive oil for 30 days), Wi-Fi (12 hours/day for 30 days), melatonin (10 mg/kg/day for 30 days) and melatonin + Wi-Fi (10 mg/kg/day + 12 hours/day for 30 days). In thirtieth day, thirty min after the last drugs administration at the indicated doses, PTZ was administered 45 mg / kg to induce epileptic seizure. The animals were observed for 30 min. Seizure stages (according to the Racine Scale) and first myoclonic jerk times (FMJ). Twenty four hours after PTZ injection, kidney tissuss were collected for biochemical evaluation. Oxidative stress markers (total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI)) were measured in kidney tissues. In the control, no electromagnetic wireless exposure was applied. The quantities of TAS, TOS and oxidative stress index (OSI) in the collected kidney tissues were compared between the control and the exposure groups. Wi-Fi reduced antioxidant effect of melatonin (p<0.05). Moreover, Wi-Fi increased cell damage in kidney tissue (p<0.05). In terms of each parameter that is indicative for antioxidant levels and oxidant activity, there were significant differences between kidney tissues (P < 0.05). This is a original study, due to the fact that by revealing in length the Wi-Fi effects of oxidative damage on kidney tissues of rats. Wi-Fi studies show that Wi-Fi causes oxidative stress and apoptosis. Wi-Fi directly reduced the effect of melotonin. The effects of Wi-Fi are caused by oxidative means.

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The anticonvulsant effect of sparteine on pentylenetetrazole-induced seizures in rats: a behavioral, electroencephalographic, morphological and molecular study

et al. 2020

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Wi-Fi decreases melatonin protective effect and increases hippocampal neuronal damage in pentylenetetrazole induced model seizures in rats

Cited by 17 publications

References 37 publications

Melatonin attenuates ovarian ischemia reperfusion injury in rats by decreasing oxidative stress index and peroxynitrite

Melatonin attenuates ovarian ischemia reperfusion injury in rats by decreasing oxidative stress index and peroxynitrite

The effect of Wireless (Wi-Fi) electromagnetic fields on oxidative stress in rat kidney tissues: A biophysical analysis

The anticonvulsant effect of sparteine on pentylenetetrazole-induced seizures in rats: a behavioral, electroencephalographic, morphological and molecular study

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