2011
DOI: 10.1016/j.mvr.2011.07.004
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Wide-field functional imaging of blood flow and hemoglobin oxygen saturation in the rodent dorsal window chamber

Abstract: The rodent dorsal window chamber is a widely used in vivo model of the microvasculature. The model consists of a 1cm region of exposed microvasculature in the rodent dorsal skin that is immobilized by surgically implanted titanium frames, allowing the skin microvasculature to be visualized. We describe a detailed protocol for surgical implantation of the dorsal window chamber which enables researchers to perform the window chamber implantation surgery. We further describe subsequent wide-field functional imagi… Show more

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Cited by 42 publications
(59 citation statements)
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“…Laser speckle imaging was used to measure neurovascular blood flow 23 . This is a previously described, noninvasive technique for studying the motion of optically scattering materials with high spatial and temporal resolution 24 .…”
Section: Laser Speckle Imagingmentioning
confidence: 99%
“…Laser speckle imaging was used to measure neurovascular blood flow 23 . This is a previously described, noninvasive technique for studying the motion of optically scattering materials with high spatial and temporal resolution 24 .…”
Section: Laser Speckle Imagingmentioning
confidence: 99%
“…The rodent dorsal chamber procedures can be found in [20]. Xenograft tumors grown subcutaneously in immune-deficient mice were excised from a skin flap and immediately imaged.…”
Section: Sample Preparationmentioning
confidence: 99%
“…[1][2][3][4][5][6][7][8][9][10] Fercher and Briers first applied LSI to visualize blood vessels in the retina. 1 Researchers have since reported on the use of LSI to map blood flow in many organs, including the brain, 5,6 skin, [7][8][9] and kidneys.…”
Section: Introductionmentioning
confidence: 99%