Wide Use of Hyaluronic Acid in the Process of Wound Healing—A Rapid Review

Antoszewska, Magdalena; Sokolewicz, Ewa Maria; Barańska-Rybak, Wioletta

doi:10.3390/scipharm92020023

Sci. Pharm.

2024

DOI: 10.3390/scipharm92020023

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Wide Use of Hyaluronic Acid in the Process of Wound Healing—A Rapid Review

Magdalena Antoszewska,

Ewa Maria Sokolewicz,

Wioletta Barańska-Rybak

Abstract: Hyaluronic acid (HA), as one of the main components of the extracellular matrix (ECM), plays an important role in the process of wound-healing and tissue-repair processes due to its unique properties and different physiological functions. HA has an ability to maintain a moist environment that promotes healing, the stimulation of growth factors and cellular constituents, and the migration of various cells essential for healing. This paper offers a review of HA use in the process of wound healing, with emphasis … Show more

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2024

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Cited by 2 publications

References 116 publications

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Development of phage-containing hydrogel for treating Enterococcus faecalis-infected wounds

Abed,

Beig,

Barzi

et al. 2024

PLoS ONE

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Background Chronic wound infections caused by Enterococcus faecalis pose formidable challenges in clinical management, exacerbated by the emergence of vancomycin-resistant strains. Phage therapy offers a targeted approach but encounters delivery hurdles. Due to their biocompatibility and controlled release properties, hydrogels hold promise as carriers. Objective This study aimed to fabricate phage-containing hydrogels using sodium alginate (SA), carboxymethyl cellulose (CMC), and hyaluronic acid (HA) to treat E. faecalis-infected wounds. We assessed the efficacy of these hydrogels both in vitro and in vivo. Methods The hydrogel was prepared using SA-CMC-HA polymers. Phage SAM-E.f 12 was incorporated into the SA-CMC-HA hydrogel. The hydrogel’s swelling index was measured after 24 h, and degradation was assessed over seven days. Surface morphology and composition were analyzed using Scanning Electron Microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR). Antibacterial activity was tested via optical density (OD) and disk diffusion assays. Phage release and stability were evaluated over a month. In vivo efficacy was tested in mice through wound healing and bacterial count assays, with histopathological analysis. Results Hydrogels exhibited a swelling index of 0.43, a water absorption rate of %30, and 23% degradation over seven days. FTIR confirmed successful polymer incorporation. In vitro studies demonstrated that phage-containing hydrogels significantly inhibited bacterial growth, with an OD of 0.3 compared to 1.1 for the controls. Hydrogels remained stable for four weeks. In vivo, phage-containing hydrogels reduced bacterial load and enhanced wound healing, as shown by improved epithelialization and tissue restoration. Conclusion Phage-containing hydrogels effectively treat wounds infected with E. faecalis-infected wounds, promoting wound healing through controlled phage release. These hydrogels can improve clinical outcomes in the treatment of infected wounds.

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Development of phage-containing hydrogel for treating Enterococcus faecalis-infected wounds

Abed,

Beig,

Barzi

et al. 2024

PLoS ONE

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Hyaluronic Acid in Nanopharmaceuticals: An Overview

Matalqah,

Lafi,

Asha

2024

CIMB

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Hyaluronic acid (HA) is a naturally occurring, long, unbranched polysaccharide that plays a critical role in maintaining skin structure and hydration. Its unique properties make it a valuable component in the field of nanopharmaceuticals. The combination of HA into nanopharmaceuticals enhances its ability to interact with various therapeutic agents, improving the delivery and efficacy of drugs. HA-based nanoparticles, including solid lipid nanoparticles, and polymeric nanogels, offer controlled release, enhanced stability, and targeted delivery of therapeutic agents. These innovations significantly improve therapeutic outcomes and reduce side effects, making HA an essential tool in modern medicine. In general, HA-modified liposomes enhance drug encapsulation and targeting, while HA-modified solid lipid nanoparticles (SLNs) provide a solid lipid core for drug encapsulation, offering controlled release and stability. This article provides an overview of the potential applications and recent advancements of HA in nanopharmaceuticals, emphasizing its significant impact on the evolving field of targeted drug delivery and advanced therapeutic strategies. By delving into the unique properties of HA and its compatibility with various therapeutic agents, this review underscores the promising potential of HA in revolutionizing nanopharmaceuticals.

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Wide Use of Hyaluronic Acid in the Process of Wound Healing—A Rapid Review

Cited by 2 publications

References 116 publications

Development of phage-containing hydrogel for treating Enterococcus faecalis-infected wounds

Development of phage-containing hydrogel for treating Enterococcus faecalis-infected wounds

Hyaluronic Acid in Nanopharmaceuticals: An Overview

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