Widening Spectrum of Liver Angiosarcoma in Children

Ackermann, O.; Fabrè, Monique; Franchi, S.; Pariente, D.; Debray, Dominique; Jacquemin, Emmanuel; Gauthier, F.; Bernard, Olivier

doi:10.1097/mpg.0b013e318230146c

Cited by 25 publications

(14 citation statements)

References 21 publications

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“… 14 – 16 Ackermann et al has reported a large tumor of IHH type 2 with early central enhancement. 6 To our knowledge, diffuse IHH with early central enhancement has not previously been reported in the English literature. In this case, the reason of central enhancement was unclear.…”

Section: Discussionmentioning

confidence: 73%

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Diffuse Infantile Hepatic Hemangioendothelioma With Early Central Enhancement in an Adult

Dong

Zuo

et al. 2015

Medicine

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Infantile hepatic hemangioendothelioma (IHH) is the most common vascular tumor of the liver in infancy. Adult with IHH is extremely rare. We presented a diffuse IHH in an adult patient with computed tomography (CT) and magnetic resonance image (MRI) findings.A 39-year-old man was admitted to our hospital because of a 2-year history of abnormal liver function tests and a 7-day history of jaundice. Physical examination revealed enlarged liver. Unenhanced abdominal CT showed enlargement of the liver with diffuse hypodensity. Enhanced CT on the arterial phase revealed multiple centrally enhanced lesions diffusely involved the enlarged liver. The enhanced areas of the lesions became larger on the portal phase and all the lesions became homogeneous enhanced on the delayed phase. These lesions showed heterogeneously hyperintense on T2-weighted image, hypointense on T1-weighted image, and early centrally enhanced on dynamic gadolinium-enhanced MRI, with complete tumor enhancement after 180 s. The patient underwent orthotopic liver transplantation. IHH type 2 was confirmed by pathology. The patient died of tumor recurrence in the liver 4 months after transplantation.Unlike the previously described imaging appearances of IHH, this case showed diffuse nodules with early central enhancement on CT and MRI. Considering the importance of the ability to differentiate IHH from other hepatic tumors, radiologists should be aware of these imaging appearances to establish knowledge of the entire spectrum of IHH.

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Section: Discussionmentioning

confidence: 73%

“…In addition, a mixture of type 1 and type 2 components within the same liver has been reported. 5 , 6 IHH may be solitary, multifocal, or diffusive. The diffuse lesions are all classified as type 2.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Infantile Hepatic Hemangioendothelioma With Early Central Enhancement in an Adult

Dong

Zuo

et al. 2015

Medicine

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“…There is a reported female predominance within the cases, and the median age is reported to be 40 months [ 62 , 65 , 66 ]. We were able to find 72 published cases of pediatric hepatic angiosarcoma since 1944 ( Supplemental Table S1 ) [ 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ].…”

Section: Malignant Tumors In Infants and Early Childhoodmentioning

confidence: 99%

“…Laboratory evaluation may be notable for consumptive coagulopathy and anemia. AFP is typically normal, as are other common tumor markers, although elevated β-hCG has been reported [ 62 , 63 , 66 , 80 , 88 ]. Pulmonary metastasis is common [ 63 ].…”

Section: Malignant Tumors In Infants and Early Childhoodmentioning

confidence: 99%

“…Environmental exposures, such as vinyl chloride, causing hepatic angiosarcoma are frequently reported in adults [ 89 ]; however, we found only one reported case of hepatic angiosarcoma secondary to arsenic exposure reported in a 20-month-old female, described by Falk et al in 1981 [ 70 ]. There have been cases reported of hepatic angiosarcoma developing in patients with multiple cutaneous infantile hemangiomas, as well as later in childhood with patients who have a history of infantile hepatic hemangiomas [ 62 , 63 , 79 , 80 , 83 ]. Jeng et al identified a de novo KRAS L19F mutation that they proposed was responsible for the malignant transformation of an infantile hemangioma [ 83 ].…”

Section: Malignant Tumors In Infants and Early Childhoodmentioning

confidence: 99%

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Pediatric Primary Hepatic Tumors: Diagnostic Considerations

2021

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The liver is the third most common site of abdominal tumors in children. This review article aims to summarize current evidence surrounding identification and diagnosis of primary hepatic tumors in the pediatric population based upon clinical presentation, epidemiology, and risk factors as well as classical imaging, histopathological, and molecular diagnostic findings. Readers will be able to recognize the features and distinguish between benign and malignant hepatic tumors within different age groups.

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Clinical case series of pediatric hepatic angiosarcoma

Grassia

Peterman

Iacobas

et al. 2017

Pediatric Blood & Cancer

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Hepatic angiosarcoma is a rare, aggressive, malignant neoplasm with fewer than 50 cases reported in children. Prognosis is poor, with a minority surviving beyond 2 years after diagnosis. We report eight cases of pediatric hepatic angiosarcoma, diagnosed at a mean age of 3 years. Seven were initially diagnosed with an infantile hepatic hemangioendothelioma (IHHE) or hemangioma and the eighth with a "vascular tumor." Two patients, who received liver transplant, survived. We suggest hepatic hemangiomas can rarely transform into angiosarcomas and a subset of IHHEs (Type II) are actually a low-grade form of angiosarcoma rather than a benign lesion.

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Widening Spectrum of Liver Angiosarcoma in Children

Cited by 25 publications

References 21 publications

Diffuse Infantile Hepatic Hemangioendothelioma With Early Central Enhancement in an Adult

Diffuse Infantile Hepatic Hemangioendothelioma With Early Central Enhancement in an Adult

Pediatric Primary Hepatic Tumors: Diagnostic Considerations

Clinical case series of pediatric hepatic angiosarcoma

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