Descendants of longevity-enriched sibships demonstrate a broad health and survival advantage throughout the life course. However, little is known about manifestations during very early life. Here we show a pattern of lower risk of adverse early life outcomes in third-generation grandchildren (N = 5637) of Danish longevity-enriched sibships compared to the general population, including infant mortality (Hazard Ratio = 0.53, 95% CI [0.36, 0.77]) and a range of neonatal health indicators. These associations in fourth-generation great-grandchildren (N = 14,908) were strongly attenuated and less consistent (e.g., infant mortality, Hazard Ratio = 0.90, [0.70, 1.17]). These dilatory patterns across successive generations were independent of stable socioeconomic and behavioural advantages (e.g., parental education and maternal smoking), maternal and paternal lines of transmission, as well as secular trends in the background population. Our findings suggest that exceptional health and survival may have early life developmental components and implicate heritable genetic and or epigenetic factors in their transmission.