Widening the View on Dispersant−Pigment Interactions in Colloidal Dispersions with Saturation Transfer Difference NMR Spectroscopy

Szczygiel, Agnieszka; Timmermans, L; Fritzinger, Bernd; Martins, José

doi:10.1021/ja905637y

Cited by 27 publications

(22 citation statements)

References 40 publications

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“…used saturation‐transfer difference (STD) NMR to investigate the association between amino acids and the polystyrene surface . STD NMR is similar to DEST in that off‐resonance saturation is used to monitor the strength of binding in an invisible, NP‐bound state. Aromatic amino acids exhibited the strongest STD effect, suggesting that significant π‐π interactions can occur between amino acid side chains and the NP surface.…”

Section: Results From Different Nanoparticle Systemsmentioning

confidence: 99%

Protein Interactions with Nanoparticle Surfaces: Highlighting Solution NMR Techniques

Perera

Hill

Fitzkee

2019

Israel Journal of Chemistry

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In the last decade, nanoparticles (NPs) have become a key tool in medicine and biotechnology as drug delivery systems, biosensors and diagnostic devices. The composition and surface chemistry of NPs vary based on the materials used: typically organic polymers, inorganic materials, or lipids. Nanoparticle classes can be further divided into sub-categories depending on the surface modification and functionalization. These surface properties matter when NPs are introduced into a physiological environment, as they will influence how nucleic acids, lipids, and proteins will interact with the NP surface. While small-molecule interactions are easily probed using NMR spectroscopy, studying protein-NP interactions using NMR introduces several challenges. For example, globular proteins may have a perturbed conforma-tion when attached to a foreign surface, and the size of NPprotein conjugates can lead to excessive line broadening. Many of these challenges have been addressed, and NMR spectroscopy is becoming a mature technique for in situ analysis of NP binding behavior. It is therefore not surprising that NMR has been applied to NP systems and has been used to study biomolecules on NP surfaces. Important considerations include corona composition, protein behavior, and ligand architecture. These features are difficult to resolve using classical surface and material characterization strategies, and NMR provides a complementary avenue of characterization. In this review, we examine how solution NMR can be combined with other analytical techniques to investigate protein behavior on NP surfaces.

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Section: Results From Different Nanoparticle Systemsmentioning

confidence: 99%

Protein Interactions with Nanoparticle Surfaces: Highlighting Solution NMR Techniques

Perera

Hill

Fitzkee

2019

Israel Journal of Chemistry

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“…Furthermore, as ligand protons in close contact with the protein receive more saturation than more distant ones, the relative intensity of the ligand resonances can be interpreted in terms of a binding epitope. Despite the broad information that this technique could provide in supramolecular systems, it has been almost exclusively utilized in protein–ligand studies and only a few studies have been performed on synthetic hosts 46 47 . Here we demonstrate the potential of STD NMR for the investigation of interactions between hybrid metal-organic Al-ITQ-HB and several substrates.…”

Section: Resultsmentioning

confidence: 99%

Organic–inorganic supramolecular solid catalyst boosts organic reactions in water

et al. 2016

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Coordination polymers and metal-organic frameworks are appealing as synthetic hosts for mediating chemical reactions. Here we report the preparation of a mesoscopic metal-organic structure based on single-layer assembly of aluminium chains and organic alkylaryl spacers. The material markedly accelerates condensation reactions in water in the absence of acid or base catalyst, as well as organocatalytic Michael-type reactions that also show superior enantioselectivity when comparing with the host-free transformation. The mesoscopic phase of the solid allows for easy diffusion of products and the catalytic solid is recycled and reused. Saturation transfer difference and two-dimensional 1H nuclear Overhauser effect NOESY NMR spectroscopy show that non-covalent interactions are operative in these host–guest systems that account for substrate activation. The mesoscopic character of the host, its hydrophobicity and chemical stability in water, launch this material as a highly attractive supramolecular catalyst to facilitate (asymmetric) transformations under more environmentally friendly conditions.

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“…Previously, we have used Saturation‐Transfer Difference (STD) NMR to examine the binding between small molecules and the surface of polystyrene (PS) nanoparticles. STD‐NMR is a ligand‐detected technique that has been widely used to detect small molecule ligands binding to protein receptors; in our recent study, we showed that this technique can be extended to consider PS nanoparticles as the “receptor.” An advantage of the STD‐NMR technique is that by comparing the relative STD effect for nuclei in the ligand, structural information regarding the binding epitopes of that ligand can be determined as well …”

Section: Introductionmentioning

confidence: 99%

Interaction between cyanine dye IR‐783 and polystyrene nanoparticles in solution

Zhang

Casabianca

2018

Magnetic Reson in Chemistry

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The interactions between small molecule drugs or dyes and nanoparticles are important to the use of nanoparticles in medicine. Noncovalent adsorption of dyes on nanoparticle surfaces is also important to the development of nanoparticle dual-use imaging contrast agents. In this work, solution-state NMR is used to examine the noncovalent interaction between a near-infrared cyanine dye and the surface of polystyrene nanoparticles in solution. Using 1D proton NMR, we can approximate the number of dye molecules that associate with each nanoparticle for different sized nanoparticles. Saturation-Transfer Difference NMR was also used to show that protons near the positively charged nitrogen in the dye are more strongly associated with the negatively charged nanoparticle surface than protons near the negatively charged sulfate groups of the dye. The methods described here can be used to study similar drug or dye molecules interacting with the surface of organic nanoparticles.

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Widening the View on Dispersant−Pigment Interactions in Colloidal Dispersions with Saturation Transfer Difference NMR Spectroscopy

Cited by 27 publications

References 40 publications

Protein Interactions with Nanoparticle Surfaces: Highlighting Solution NMR Techniques

Protein Interactions with Nanoparticle Surfaces: Highlighting Solution NMR Techniques

Organic–inorganic supramolecular solid catalyst boosts organic reactions in water

Interaction between cyanine dye IR‐783 and polystyrene nanoparticles in solution

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