2015
DOI: 10.3201/eid2201.151314
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Widespread Bat White-Nose Syndrome Fungus, Northeastern China

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Cited by 55 publications
(60 citation statements)
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“…Thus, extremely low detection of P. destructans on exposed, tolerant hosts, and the absence of conidia or cupping erosions detected during histopathological examination implies potential inhibition of pathogen activity. Tolerant hosts may not need to mount an immune response if they are able to repress P. destructans growth and pathogenicity, which could potentially be accomplished through secreted skin proteins or through the secretions of commensal bacteria (Hoyt et al., 2015, 2016a,b). We note that our results suggest potential mechanisms of resistance as well as tolerance, because we did not observe pathogen loads on M. myotis comparable to those seen on M. lucifugus exposed following the same protocol (Supporting information).…”
Section: Discussionmentioning
confidence: 99%
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“…Thus, extremely low detection of P. destructans on exposed, tolerant hosts, and the absence of conidia or cupping erosions detected during histopathological examination implies potential inhibition of pathogen activity. Tolerant hosts may not need to mount an immune response if they are able to repress P. destructans growth and pathogenicity, which could potentially be accomplished through secreted skin proteins or through the secretions of commensal bacteria (Hoyt et al., 2015, 2016a,b). We note that our results suggest potential mechanisms of resistance as well as tolerance, because we did not observe pathogen loads on M. myotis comparable to those seen on M. lucifugus exposed following the same protocol (Supporting information).…”
Section: Discussionmentioning
confidence: 99%
“…Wild M. myotis do often develop mild symptoms of WNS, although disease prevalence may vary among regions (Hoyt et al., 2016a,b; Wibbelt et al., 2010; Zukal et al., 2016). It is not yet clear what drives this variation.…”
Section: Discussionmentioning
confidence: 99%
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