Widespread Changes in White Matter Microstructure after a Day of Waking and Sleep Deprivation

Elvsåshagen, Torbjørn; Norbom, Linn B.; Pedersen, Per Øystein Heiberg; Quraishi, Sophia H.; Bjørnerud, Atle; Malt, Ulrik Fredrik; Groote, Inge Rasmus; Westlye, Lars T.

doi:10.1371/journal.pone.0127351

Cited by 74 publications

(91 citation statements)

References 66 publications

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“…Therefore, it is possible that the lack of significant associations with measures of persistent poor sleep may reflect limitations associated with the Jenkins Sleep Scale. In addition, since short‐term sleep deprivation has been associated with impaired performance in tests of attention, processing speed, working memory and short‐term memory [Lim and Dinges, ], as well as widespread fractional anisotropy decreases [Elvsåshagen et al, ], it is possible that our results reflect short‐term, potentially reversible, mechanisms associated with poor sleep.…”

Section: Discussionmentioning

confidence: 92%

Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study

Sexton

Zsoldos

Filippini

et al. 2017

Human Brain Mapping

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Both sleep disturbances and decline in white matter microstructure are commonly observed in ageing populations, as well as in age‐related psychiatric and neurological illnesses. A relationship between sleep and white matter microstructure may underlie such relationships, but few imaging studies have directly examined this hypothesis. In a study of 448 community‐dwelling members of the Whitehall II Imaging Sub‐Study aged between 60 and 82 years (90 female, mean age 69.2 ± 5.1 years), we used the magnetic resonance imaging technique diffusion tensor imaging to examine the relationship between self‐reported sleep quality and white matter microstructure. Poor sleep quality at the time of the diffusion tensor imaging scan was associated with reduced global fractional anisotropy and increased global axial diffusivity and radial diffusivity values, with small effect sizes. Voxel‐wise analysis showed that widespread frontal‐subcortical tracts, encompassing regions previously reported as altered in insomnia, were affected. Radial diffusivity findings remained significant after additional correction for demographics, general cognition, health, and lifestyle measures. No significant differences in general cognitive function, executive function, memory, or processing speed were detected between good and poor sleep quality groups. The number of times participants reported poor sleep quality over five time‐points spanning a 16‐year period was not associated with white matter measures. In conclusion, these data demonstrate that current sleep quality is linked to white matter microstructure. Small effect sizes may limit the extent to which poor sleep is a promising modifiable factor that may maintain, or even improve, white matter microstructure in ageing. Hum Brain Mapp 38:5465–5473, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 92%

Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study

Sexton

Zsoldos

Filippini

et al. 2017

Human Brain Mapping

View full text Add to dashboard Cite

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“…Similarly, sleep disturbance is associated with distinct alterations in default mode network functional connectivity in brain regions underpinning salient memory and sleep systems . More specifically, sleep deprivation caused widespread changes in white matter (WM) microstructure . Therefore, previous studies have shown that sleep disturbance was associated with brain abnormalities .…”

Section: Introductionmentioning

confidence: 99%

Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with chronic fatigue syndrome

et al. 2017

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Funding information The Judith Jane Mason FoundationUnrefreshing sleep is a hallmark of chronic fatigue syndrome/myalgic encephalomyelitis (CFS).This study examined brain structure variations associated with sleep quality in patients with CFS. 38 patients with CFS (34.8 ± 10.1 years old) and 14 normal controls (NCs) (34.7 ± 8.4 years old) were recruited. All subjects completed the Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index (PSQI), and Chalder Fatigue Scale (CFQ) questionnaires. Brain MRI measures included global and regional grey and white matter volumes, magnetization transfer T 1 weighted (MT-T1w) intensities, and T 1 weighted (T1w) and T 2 weighted spin echo signal intensities. We performed voxel based group comparisons of these regional brain MRI measures and regressions of these measures with the PSQI and CFQ scales adjusted for age, anxiety and depression, and the appropriate global measure. In CFS patients, negative correlations were observed in the medial prefrontal cortex (mPFC) between PSQI and MT-T1w intensities (family-wise error corrected cluster, P FWE < 0.05) and between PSQI and T1w intensities (P FWE < 0.05). In the same mPFC location, both MT and T1w intensities were lower in CFS patients compared with NCs (uncorrected voxel P < 0.001). This study is the first to report that brain structural differences are associated with unrefreshing sleep in CFS. This result refutes the suggestion that unrefreshing sleep is a misperception in CFS patients and further investigation of this symptom is warranted. Sleep plays an important role in human health and well-being, with its recuperative, restorative, and learning consolidation properties. 4,5Unrefreshing sleep is a hallmark of ME/CFS that causes patients to wake up feeling tired even after extended periods of sleep, to experience excessive daytime sleepiness, and to have difficulty falling asleep and staying asleep. Therefore, unrefreshing sleep results at least in worsening fatigue symptoms and adds to the 'illness burden' in CFS patients. 6 Roughly 91% of CFS patients report unrefreshing sleep regardless of adequate sleep duration. 7 The effect of unrefreshing sleep is of importance in CFS aetiology because sleep disturbance can cause fatigue, myalgia, and poor attention. 8 A recent path analysis study, exploring the interrelationship of different symptoms in CFS, found that poor sleep quality directly impacted on

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“…One study excluded dehydration as the possible culprit (Vogel et al, ). It is known that WM microstructure can be affected by a variety of factors, including sleep deprivation (Elvsåshagen et al, ) and fasting (Bakan et al, ). In sum, despite inconsistencies studies strongly suggest the presence of WM microstructure alterations in acutely ill patients.…”

Section: Introductionmentioning

confidence: 99%

“…One study excluded dehydration as the possible culprit (Vogel et al, 2016). It is known that WM microstructure can be affected by a variety of factors, including sleep deprivation (Elvsåshagen et al, 2015) and fasting (Bakan et al, 2015).…”

mentioning

confidence: 99%

Normal white matter microstructure in women long‐term recovered from anorexia nervosa: A diffusion tensor imaging study

Bang

Rø

Endestad

2017

Intl J Eating Disorders

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Objectives: Studies point to white matter (WM) microstructure alterations in both adolescent and adult patients with anorexia nervosa (AN). These include reduced fractional anisotropy in several WM fiber tracts, suggesting reduced WM integrity. The extent to which these alterations are reversible with recovery from AN is unclear. There is a paucity of research investigating the presence of WM microstructure alterations in recovered AN patients, and results are inconsistent. This study aimed to investigate the presence of WM microstructure alterations in women long-term recovered from AN.Method: Twenty-one adult women who were recovered from AN for at least 1 year were compared to 21 adult comparison women. Participants were recruited via user-organizations for eating disorders, local advertisements, and online forums. Diffusion tensor imaging was used to compare WM microstructure between groups. Correlations between WM microstructure and clinical characteristics were also explored.Results: There were no statistically significant between-group differences in WM microstructure.These null findings remained when employing liberal alpha level thresholds. Furthermore, there were no statistically significant correlations between WM microstructure and clinical characteristics. Discussion: Our findings showed normal WM microstructure in long-term recovered patients, indicating the alterations observed during the acute phase are reversible. Given the paucity of research and inconsistent findings, future studies are warranted to determine the presence of WM microstructure alterations following recovery from AN. K E Y W O R D Sanorexia nervosa, diffusion tensor imaging, magnetic resonance imaging, neurobiology, white matter microstructure

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Widespread Changes in White Matter Microstructure after a Day of Waking and Sleep Deprivation

Cited by 74 publications

References 66 publications

Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study

Associations between self‐reported sleep quality and white matter in community‐dwelling older adults: A prospective cohort study

Medial prefrontal cortex deficits correlate with unrefreshing sleep in patients with chronic fatigue syndrome

Normal white matter microstructure in women long‐term recovered from anorexia nervosa: A diffusion tensor imaging study

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