Widespread Distribution of a Chorionic Gonadotropin- Like Substance in Normal Human Tissues*

Braunstein, Braunstein; Kamdar, Vikram; Rasor, Joan; Swaminathan, N.; Wade, Maclyn E.

doi:10.1210/jcem-49-6-917

Cited by 125 publications

(29 citation statements)

References 14 publications

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“…2,4,[6][7][8]16,17) hCG production in cases of bronchogenic carcinoma that also gave rise to gynecomastia is rarely reported. 5,21) However, 12% of patients with lung cancer had elevated levels of immunoreactive hCG/hCGb, but the increase in immunoreactive hCG/hCGb in the serum was mainly attributable to free hCGb, not to intact hCG composed of a-and b-subunits.…”

Section: Discussionmentioning

confidence: 99%

“…Elevated serum levels of immunoreactive hCG or b-subunit of hCG (hCGb) are often found in patients with various nontrophoblastic neoplasms, which are known as ectopic hCG/hCGb-producing tumors. 2,4,[6][7][8]16,17) Germ cell tumors and metastatic choriocarcinoma in the brain produce hCG. We report a rare case of a cerebellar tumor which presented as cerebellar hemorrhage and was identified as a metastatic bronchogenic carcinoma producing hCG ectopically.…”

Section: Introductionmentioning

confidence: 99%

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Metastatic Bronchogenic Carcinoma with Human Chorionic Gonadotropin Production Manifesting as Cerebellar Hemorrhage. Case Report.

Sawa

Taomoto

Tamaki

et al. 2001

Neurol. Med. Chir.(Tokyo)

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A 58-year-old male presented with a rare case of brain metastatic bronchogenic carcinoma with human chorionic gonadotropin (hCG) production causing cerebellar hemorrhage with symptoms of nausea, vomiting, and headache. Bronchogenic carcinoma manifesting as gynecomastia had been resected a few months previously. Neurological examination revealed left cerebellar ataxia. Neuroimaging showed multiple cerebellar metastases with cerebellar hemorrhage adjacent to the tentorium. Angiography demonstrated tumor staining fed by the hemispheric branch of the left posterior inferior cerebellar artery. Suboccipital craniectomy was performed. The left cerebellar hematoma was evacuated and the tumor was partially removed to prevent massive intraoperative hemorrhage and avoid brain stem injury. Histological examination showed the resected tumor was large cell carcinoma. hCG was detected in the cerebrospinal fluid and was identified by immunohistochemical staining in tumor cells. The primary lesion of bronchogenic carcinoma showed choriocarcinomatous change because the tumor could produce hCG. The choriocarcinomatous cells with higher metastatic potential formed lesions in the brain, and finally intratumoral hemorrhage occurred producing the rapid development of symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Metastatic Bronchogenic Carcinoma with Human Chorionic Gonadotropin Production Manifesting as Cerebellar Hemorrhage. Case Report.

Sawa

Taomoto

Tamaki

et al. 2001

Neurol. Med. Chir.(Tokyo)

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“…In normal testicular tissues, Brounstein et al [6] g -tissue, and Arakawa [2] reported the mean value of 66.6 ng/g .tissue, for their 10 cases. The latter author also indicated a decreasing tendency in the hCGP level with age.…”

Section: Discussionmentioning

confidence: 99%

Human Chorionic Gonadotropin β-Subunit in Human Semen

Saito

Kumamoto

Ito

et al. 1988

Archives of Andrology

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The level of human seminal chorionic gonadotropin 0-subunit (hCGP) was determined by radioimmunoassay (RIA). The mean hCGP level in 34 normal men was 3.7 f 1.6 ngfml, which was much higher than that in serum. The mean hCG0 level for 20 patients with mild oligozoospermia (20-39 x lo6 sperm/ml) was 2.5 f 0.8 ng/ml, that for 34 patients with severe oligozoospermia (1-19 x lo6 sperm/ ml) was 1.7 f 0.5 ng/ml, and that for 21 azoospermia was 1.5 * 0.6 ng/ml. Thus, the decrease of sperm count was correlated with the decrease of hCGP. In 17 cases to which testicular biopsy was applied together with sperm counting, the seminal hCG0 level was found to positively correlate with the germinal cell index (the ratio germinal cell count/Sertoli cell count) and with the testicular volume. The level of seminal hCGP was also found to correlate negatively with the levels of seminal LH and FSH and positively with the Ipvel of seminal testosterone. These findings suggest that the production of seminal hCGP is a process of spermatogenesis and closely related to spermatogenesis. The level of hCGP in serum was too low to detect, and no relation to that in seminal plasma could be investigated. However, in 6 cases with testicular tumor, the hCGP level in serum was high, whereas that in seminal plasma was rather low probably because of unilateral secretion. Enhanced production of hCG0 by tumor tissues and the dp-truction of the blood-testis barrier by proliferation of tumor cells seemed to be one of the causes of this high hCGP level in serum. The hCG0 levels in 13 vasectomized seminal plasma and the prostatic fluid samples collected from 3 normal men were 1.5 ng/ml, which was similar to those in azoospermic patients. These findings suggest that the seminal hCGP level consists of the hCGP secreted by the testis and about 1.5 nglml of hCGP from the prostate. Based on these results, seminal hCGP is thought to be secreted by the prostate and the process of spermatogenesis and the value of seminal hCGP may serve as an effective index for the testicular function.

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“…Some of these forms of the hormone appear to be subunits of hCG (1)(2)(3)(4)(5)(6)(7), and some appear to be fragments, as they exhibit molecular sizes smaller than those of the hCG subunits (1,5,6,(8)(9)(10)(11). When obtained from different sources, hCG itself has been found to have variable biological, physicochemical, and immunological properties; this microheterogeneity seems to be related, in part, to variations in its carbohydrate composition (10,(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Characterization of a carboxyterminal peptide fragment of the human choriogonadotropin beta-subunit excreted in the urine of a woman with choriocarcinoma.

Amr¹,

Wehmann²,

Birken³

et al. 1983

J. Clin. Invest.

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A B S T R A C T We have observed low-molecular weight carboxyterminal fragments of the human choriogonadotropin (hCG) a-subunit in the urines of several women with choriocarcinoma, and we have characterized one fragment in detail. Its apparent molecular weight by gel chromatography on Sephadex G-100 was 14,200. The fragment was not adsorbed to concanavalin A-Sepharose, indicating that it lacked the asparagine-linked carbohydrate groups of intact hCG#. It was active in radioimmunoassays (RIA) using antisera either to the hCG# carboxyterminal peptide (CTP) or to the desialylated hCG# CTP (hCG# as-CTP), indicating the presence of not only the hCG# carboxyterminus but also desialylated O-serine-linked carbohydrate side chains on the fragment. It lacked luteinizing hormone/choriogonadotropin radioreceptor activity and hCG# conformational immunoreactivity (SB6 RIA). On Sephadex G-100 gel chromatography, the elution profiles of this fragment and the hCG# as-CTP(115-145) prepared by trypsin digestion of ashCG were essentially indistinguishable (apparent molecular weights 14,200 and 14,000, respectively). The immunological characteristics of the fragment in both hCG# CTP and hCG# as-CTP RIA were indistinguishable from those of the hCG,6 as-CTP(115-145) glycopeptide. Carboxyterminal fragments of hCG# were evident in urine specimens obtained from 10 of 11 patients with choriocarcinoma but not in those ob-

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Widespread Distribution of a Chorionic Gonadotropin- Like Substance in Normal Human Tissues*

Cited by 125 publications

References 14 publications

Metastatic Bronchogenic Carcinoma with Human Chorionic Gonadotropin Production Manifesting as Cerebellar Hemorrhage. Case Report.

Metastatic Bronchogenic Carcinoma with Human Chorionic Gonadotropin Production Manifesting as Cerebellar Hemorrhage. Case Report.

Human Chorionic Gonadotropin β-Subunit in Human Semen

Characterization of a carboxyterminal peptide fragment of the human choriogonadotropin beta-subunit excreted in the urine of a woman with choriocarcinoma.

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