Widespread Emergence of Methicillin Resistance in Community-acquired Staphylococcus aureus Infections in Denver

Clancy, Megan; Graepler, Amy; Breese, Peter; Price, Connie S.; Burman, William J.

doi:10.1097/01.smj.0000184800.83171.f7

Cited by 18 publications

(27 citation statements)

References 19 publications

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“…14,18 However, during the last several years, CA-MRSA infections have been noted in patients without these risk factors. [15][16][17]19,20,24 Consistent with these reports, our study found no significant difference between MRSA-positive and MRSA-negative patients with respect to CA-MRSA risk factors, bringing into question the usefulness of the risk factor profile.…”

Section: Discussionmentioning

confidence: 99%

“…14-17 These CA-MRSA infections have become increasingly common, and now affect patients who lack previously identified MRSA risk factors. 14,[18][19][20] Some authors have noted that CA-MRSA possesses a number of virulence factors that have been associated with more aggressive disease. 21,22 In addition, CA-MRSA often possesses 'different antibiotic susceptibilities than hospital-acquired MRSA.…”

mentioning

confidence: 99%

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MRSA-Related Perianal Abscesses: An Underrecognized Disease Entity

Albright¹,

Pidala²,

Cali³

et al. 2007

Diseases of the Colon &Amp; Rectum

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The prevalence of MRSA in perianal abscesses has not been described previously and is higher in our group of patients than would be expected. MRSA-positive patients cannot be identified by risk factors alone. Antibiotic resistance spectra of MRSA vary from that of enteric bacteria typically seen in perianal abscesses. Therefore, it may be beneficial to culture all perianal abscesses with extensive induration and erythema or minimal purulence.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

MRSA-Related Perianal Abscesses: An Underrecognized Disease Entity

Albright¹,

Pidala²,

Cali³

et al. 2007

Diseases of the Colon &Amp; Rectum

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“…However, the proportion caused by CA-MRSA strains (defined by a specific antibiotic susceptibility pattern) doubled from 24% to 49% (732). In Denver, CO, at a city-owned hospital and its affiliated clinics, the number of community-acquired (i.e., a culture obtained from an ED or clinic or within 48 h after a hospital admission) S. aureus SSTIs did not increase overall, but the percentage caused by MRSA increased from 6% in the first quarter of 2002 to 45% in the second quarter of 2004 (P Ͻ 0.001) (173). Similarly, in the Calgary Health Region of Canada, as MRSA became a more common cause of S. aureus bacteremia in 2000 to 2006, the total incidence of S. aureus bacteremia did not rise (512).…”

Section: Ca-mrsa: An Epidemic and Its Originsmentioning

confidence: 99%

Community-Associated Methicillin-ResistantStaphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic

2010

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SUMMARY Staphylococcus aureus is an important cause of skin and soft-tissue infections (SSTIs), endovascular infections, pneumonia, septic arthritis, endocarditis, osteomyelitis, foreign-body infections, and sepsis. Methicillin-resistant S. aureus (MRSA) isolates were once confined largely to hospitals, other health care environments, and patients frequenting these facilities. Since the mid-1990s, however, there has been an explosion in the number of MRSA infections reported in populations lacking risk factors for exposure to the health care system. This increase in the incidence of MRSA infection has been associated with the recognition of new MRSA clones known as community-associated MRSA (CA-MRSA). CA-MRSA strains differ from the older, health care-associated MRSA strains; they infect a different group of patients, they cause different clinical syndromes, they differ in antimicrobial susceptibility patterns, they spread rapidly among healthy people in the community, and they frequently cause infections in health care environments as well. This review details what is known about the epidemiology of CA-MRSA strains and the clinical spectrum of infectious syndromes associated with them that ranges from a commensal state to severe, overwhelming infection. It also addresses the therapy of these infections and strategies for their prevention.

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“…1 More recently, Clancy et al 2 described an increase in CA-MRSA strains in Denver, Colorado, from 6% to 45% during a 2-year period. The patients infected with these strains did not have the typical risk factors for MRSA.…”

mentioning

confidence: 99%

“…9 Since then, multiple reports have been published. 2,[7][8][9] Four deaths due to CA-MRSA occurred in Minnesota during a 2-year period. 8 In one Texas…”

mentioning

confidence: 99%

Community-Acquired Methicillin-Resistant Staphylococcus Aureus Epidural Abscess With Bacteremia and Multiple Lung Abscesses: Case Report

Bruns

Sood

2009

American Journal of Critical Care

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A systemic infection due to community-acquired methicillin-resistant Staphylococcus aureus occurred in a hospital-naive 17-year-old girl with no history of soft-tissue infection. Although the initial signs and symptoms were indolent, systemic manifestations occurred, including extensive lung parenchymal damage and acute respiratory distress syndrome. The patient required long-term mechanical ventilation and was given linezolid for 8 weeks. Blood cultures eventually became negative for the staphylococci, and the patient was discharged to a rehabilitation facility. A probable source of the infection was the patient's selfcutting and self-piercing.

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Widespread Emergence of Methicillin Resistance in Community-acquired Staphylococcus aureus Infections in Denver

Cited by 18 publications

References 19 publications

MRSA-Related Perianal Abscesses: An Underrecognized Disease Entity

MRSA-Related Perianal Abscesses: An Underrecognized Disease Entity

Community-Associated Methicillin-ResistantStaphylococcus aureus: Epidemiology and Clinical Consequences of an Emerging Epidemic

Community-Acquired Methicillin-Resistant Staphylococcus Aureus Epidural Abscess With Bacteremia and Multiple Lung Abscesses: Case Report

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