1990
DOI: 10.1148/radiology.177.3.2243998
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Widespread inflammatory response to osteoblastoma: the flare phenomenon.

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Cited by 91 publications
(45 citation statements)
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“…Possible mechanisms generating edema surrounding tumors have been described [21] and the edema represents a nonspecific response of tissue to a stimulus. Histological examination of these areas revealed edematous fluid together with inflammatory cells [18,19], but this inflammatory response was not invariably found in other series [16].…”
Section: Discussionmentioning
confidence: 83%
See 1 more Smart Citation
“…Possible mechanisms generating edema surrounding tumors have been described [21] and the edema represents a nonspecific response of tissue to a stimulus. Histological examination of these areas revealed edematous fluid together with inflammatory cells [18,19], but this inflammatory response was not invariably found in other series [16].…”
Section: Discussionmentioning
confidence: 83%
“…These appearances can be confusing, although the mere presence and quantity of marrow and soft tissue edema are unreliable indicators of the biological potential of a lesion [16]. Features indicative of tumor-associated bone marrow edema are frequently found in benign disorders such as osteoid osteoma, osteoblastoma and chondroblastoma [16,17,18,19,20]. Weatherall et al [7] found 19 of 22 patients with chondroblastoma had bone marrow edema and a periosteal reaction was demonstrated in 18 patients, while Jee et al [6] reported 82% with similar features.…”
Section: Discussionmentioning
confidence: 99%
“…This radiographic appearance can be somewhat confusing to the radiographic examiner, who may interpret these tumors as entities such as Ewing's sarcoma or lymphoma. 21 Adjacent bone remodeling at the level of the articular facet may present as facet hypertrophy. This may be a secondary inflammatory reaction to the osteoblastoma.…”
Section: Radiographic Presentation and Locationmentioning
confidence: 99%
“…Significant peritumoral soft tissueedemaandgadolinium enhancement, re lated to an associatedinflammatory response, may exacerbate the extent of signal intensity alteration on MR [7,8]. This so-called flare phenomenon has been described with other bone tumors such as osteoid osteoma and chondroblastoma [8].…”
Section: Referencesmentioning
confidence: 97%