Widespread Metastasis to the Stomach 10 Years After Primary Breast Cancer

Abstract

Rationale: Breast cancer is a common malignant tumor. The most common metastatic sites of breast cancer are the bone, brain, liver and lung, and gastrointestinal metastases are rare. Considering that the median time interval from the initial breast cancer diagnosis to stomach metastasis is 77.5 months, gastrointestinal metastases are rarely observed 10 years after primary breast cancer. Patient concerns: Here, we present a 63-year-old female with unusual endoscopy results that revealed scattered polyps and mucosal infiltration throughout the stomach, which were later confirmed to be metastatic lobular carcinoma of the breast that had been surgically removed 10 years earlier. Diagnosis: The patient was diagnosed with gastric metastases of breast cancer by immunohistochemistry. Interventions: The patient underwent endocrine therapy with palbociclib and tamoxifen. Outcomes: After 1 year of endocrine therapy, the symptoms of upper abdominal discomfort and fatigue were relieved and a new gastroscopy revealed there had been no significant progression of the gastric metastasis. According to the Response Evaluation Criteria in Solid Tumors (RECIST), the patient reached a state of stable disease. Lessons: Gastric metastases of breast cancer are rare in the clinical setting. However, considering the possibility of gastric metastases from breast cancer and performing an upper endoscopy are crucial for patients who present with any subtle gastric symptoms and have a past medical history of breast cancer, even if the breast cancer occurred more than 10 years ago.

Gastric Outlet Obstruction Secondary to Metastatic Breast Carcinoma 25 Years After Initial Diagnosis: A Mimic of Primary Gastric Carcinoma

“…6,7 A literature review revealed our case to be the longest time from diagnosis of primary breast cancer to distant metastasis to the stomach documented, with the next longest being 13 years. 7 Because breast cancer has been estimated to be the most common source of gastric metastasis, accounting for up to 37% of cases, followed by melanoma (25%) and ovarian cancer (14%), clinicians and pathologists must have a high level of clinical suspicion. 8 Thus, this case illustrates the importance of a thorough knowledge of the patient's history of even remote diseases.…”

Selected Patients With Peritoneal Metastases From Breast Cancer May Benefit From Cytoreductive Surgery: The Results of a Multicenter Survey

“…( 1 ) reporting their over 18 years’ experience in a major European center for PSM treatment reported an extremely poor outcome in 22 patients with PMBC, with 3.8% of all cases observed in the same period with a median OS rate of only 5.8. months. Apart from a single case report ( 27 , 28 ), others who analyzed case series including numerous patients with PMBC reported an outcome after hormone or chemotherapy treatments that ranged from a median OS of 1.5 to 19 months ( 13 , 29 , 30 ). In a small series analyzing PMBC exclusively involving gynecological areas, surgical excision combined with complete CRS achieves a median OS of 34 to 36 months ( 31 , 32 ).…”

Breast metastasis of cervical cancer: A case report and systematic literature review

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