Widespread pain hypersensitivity and facilitated temporal summation of deep tissue pain in whiplash associated disorder: An explorative study of women

Lemming, Dag; Graven‐Nielsen, Thomas; Sörensen, Jan; Arendt-Nielsen, Lars; Gerdle, Björn

doi:10.2340/16501977-1006

Cited by 59 publications

(54 citation statements)

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“…Results of a recent study raised evidence for impaired descending pain inhibition in chronic whiplash patients such that the application of ischemic pain as conditioning stimulus did not diminish the perception of pressure pain stimuli 42. In line with deficient endogenous pain inhibition, widespread deep tissue hyperalgesia in chronic whiplash was associated with enhanced TS to pressure pain stimuli 43,44…”

Section: Introductionmentioning

confidence: 96%

Personalized Pain Medicine: The Clinical Value of Psychophysical Assessment of Pain Modulation Profile

Granovsky¹,

Yarnitsky²

2013

Rambam Maimonides Med J

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Experimental pain stimuli can be used to simulate patients’ pain experience. We review recent developments in psychophysical pain testing, focusing on the application of the dynamic tests—conditioned pain modulation (CPM) and temporal summation (TS). Typically, patients with clinical pain of various types express either less efficient CPM or enhanced TS, or both. These tests can be used in prediction of incidence of acquiring pain and of its intensity, as well as in assisting the correct choice of analgesic agents for individual patients. This can help to shorten the commonly occurring long and frustrating process of adjusting analgesic agents to the individual patients. We propose that evaluating pain modulation can serve as a step forward in individualizing pain medicine.

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Section: Introductionmentioning

confidence: 96%

Personalized Pain Medicine: The Clinical Value of Psychophysical Assessment of Pain Modulation Profile

Granovsky¹,

Yarnitsky²

2013

Rambam Maimonides Med J

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“…There is no formal study of the PSD scale in WAD to date. However, to support this notion, a number of studies of patients who are considered to have WAD have found psychophysical characteristics typical of patients deemed to have FM 10,11,12,13,14,15,16 .…”

Section: Rheumatologymentioning

confidence: 99%

Whiplash: Same Elephant, Different Room

Littlejohn

Guymer²

2014

J Rheumatol

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“…Facilitated temporal summation is a feature of central sensitization, and is characteristic of many chronic musculoskeletal disorders including whiplash [42], fibromyalgia [43], and temporomandibular disorder [44]. Interestingly, experimentally induced delayed onset muscle soreness (DOMS) resulted in ipsilateral, but not contralateral, changes in temporal summation at 24 hours post-exercise [45], indicating that facilitation of this mechanism may occur more locally.…”

Section: Temporal Summationmentioning

confidence: 99%

Neuromuscular Function in Painful Knee Osteoarthritis

Courtney

O’Hearn

Hornby

2012

Curr Pain Headache Rep

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Pain is a major cause of impaired mobility in elderly patients with chronic osteoarthritis (OA) of the knee. Central sensitization and impaired nociceptive inhibitory mechanisms have both been identified as contributing factors to heightened pain in this patient population. While central sensitization has been shown to produce enhanced pain responses and spread of pain to adjacent and remote body regions, conditioned pain modulation has also been shown to be adversely affected, and may be characteristic of those patients with chronic pain. Alterations of quantitative sensory testing measures have been demonstrated in patients with knee OA, and may serve as a clinical means of staging chronic musculoskeletal pain, including assessment of hyperalgesia and hypoesthesia. In addition, pain and altered somatosensation commonly associated with OA may be correlated with functional deficits.

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Widespread pain hypersensitivity and facilitated temporal summation of deep tissue pain in whiplash associated disorder: An explorative study of women

Abstract: The results indicated widespread hyperalgesia in chronic whiplash associated disorder and facilitated temporal summation outside the primary pain area, suggesting involvement of central sensitization.

Cited by 59 publications

References 0 publications

Personalized Pain Medicine: The Clinical Value of Psychophysical Assessment of Pain Modulation Profile

Personalized Pain Medicine: The Clinical Value of Psychophysical Assessment of Pain Modulation Profile

Whiplash: Same Elephant, Different Room

Neuromuscular Function in Painful Knee Osteoarthritis

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