Widespread Pain in Patients with Complex Regional Pain Syndrome

Birley, Thomas; Göebel, Andreas

doi:10.1111/papr.12092

Cited by 15 publications

(14 citation statements)

References 20 publications

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“…Research shows that some people with CRPS experience widespread pain [7], which could confound the assessment of CRPS related pain. For this reason, the individual will be asked to consider and report only the pain related to the CRPS when completing the instrument.…”

Section: Resultsmentioning

confidence: 99%

Recommendations for a first Core Outcome Measurement set for complex regional PAin syndrome Clinical sTudies (COMPACT)

Grieve

Pérez

Birklein

et al. 2017

Pain

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Complex regional pain syndrome (CRPS) is a persistent pain condition that remains incompletely understood and challenging to treat. Historically, a wide range of different outcome measures have been used to capture the multidimensional nature of CRPS. This has been a significant limiting factor in the advancement of our understanding of the mechanisms and management of CRPS. In 2013, an international consortium of patients, clinicians, researchers, and industry representatives was established, to develop and agree on a minimum core set of standardised outcome measures for use in future CRPS clinical research, including but not limited to clinical trials within adult populations. The development of a core measurement set was informed through workshops and supplementary work, using an iterative consensus process. "What is the clinical presentation and course of CRPS, and what factors influence it?" was agreed as the most pertinent research question that our standardised set of patient-reported outcome measures should be selected to answer. The domains encompassing the key concepts necessary to answer the research question were agreed as follows: pain, disease severity, participation and physical function, emotional and psychological function, self-efficacy, catastrophizing, and patient's global impression of change. The final core measurement set included the optimum generic or condition-specific patient-reported questionnaire outcome measures, which captured the essence of each domain, and 1 clinician-reported outcome measure to capture the degree of severity of CRPS. The next step is to test the feasibility and acceptability of collecting outcome measure data using the core measurement set in the CRPS population internationally.

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Section: Resultsmentioning

confidence: 99%

Recommendations for a first Core Outcome Measurement set for complex regional PAin syndrome Clinical sTudies (COMPACT)

Grieve

Pérez

Birklein

et al. 2017

Pain

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“…Increased immune cell proximity to nerve fibres has been reported in other chronic pain conditions (Barbara et al., ), and may represent one mechanism by which subtle peripheral immune activation could contribute to sensory nerve activation. Finally, the age of our experimental group was somewhat lower than the average age of patients with long‐standing CRPS seen at both our and other tertiary centres (Allen et al., ; Birley and Goebel, ), and by necessity (see section ) we included a high proportion of patients with lower limb CRPS. We cannot exclude that the skin immunopathology in older patients or patients with upper limb CRPS might be different from what we have found.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous immunopathology of long‐standing complex regional pain syndrome

Osborne

Farrell

Dearman

et al. 2015

European Journal of Pain

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“…Although pain location has been linked to function and psychological conditions in patients with chronic non-malignant pain [14,18,23] and the extent of pain has been consistently linked to pain interference in different patient populations [1,6,35], little is currently known regarding patterns of pain experienced by individuals after MVC. In addition, little is currently known regarding how these patterns of pain influence overall pain interference and specific functional disability and this influence evolves over time.…”

Section: Introductionmentioning

confidence: 99%

Effect of pain location and duration on life function in the year after motor vehicle collision

Bortsov

Platts‐Mills

Peak

et al. 2014

Pain

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Persistent musculoskeletal pain is common after motor vehicle collision (MVC) and often results in substantial disability. The objective of this study was to identify distributions of post-MVC pain which most interfere with specific life functions and which have the greatest interference with aggregate life function. Study data were obtained from a prospective longitudinal multicenter emergency department-based cohort of 948 European Americans experiencing MVC. Overall pain (0–10 numeric rating scale (NRS)), pain in each of 20 body regions (0–10 NRS), and pain interference (Brief Pain Inventory, 0–10 NRS) were assessed 6 weeks, 6 months, and 1 year after MVC. After adjustment for overall pain intensity, an axial distribution of pain caused the greatest interference with most specific life functions (R2 = 0.15–0.28, association p-values <.001) and with overall function. Axial pain explained more than twice as much variance in pain interference as other pain distributions. However, not all patients with axial pain had neck pain. Moderate or severe low back pain was as common as neck pain at week 6 (prevalence 37% for each) and overlapped with neck pain in only 23% of patients. Further, pain across all body regions accounted for nearly twice as much of the variance in pain interference as neck pain alone (60% vs. 34%). These findings suggest that studies of post-MVC pain should not focus on neck pain alone.

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Widespread Pain in Patients with Complex Regional Pain Syndrome

Abstract: In this systematic assessment of the incidence of widespread pain in a large cohort of patients with CRPS, important widespread pain affected > 10% of patients. Our data support the inclusion of routine enquiries about additional pains in the clinical assessment of patients with CRPS.

Cited by 15 publications

References 20 publications

Recommendations for a first Core Outcome Measurement set for complex regional PAin syndrome Clinical sTudies (COMPACT)

Recommendations for a first Core Outcome Measurement set for complex regional PAin syndrome Clinical sTudies (COMPACT)

Cutaneous immunopathology of long‐standing complex regional pain syndrome

Effect of pain location and duration on life function in the year after motor vehicle collision

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