Widespread papules and nodules in a Ugandan man with acquired immunodeficiency syndrome. African blastomycosis

Lm, Cohen; Le, Golitz; Ml, Wilson

doi:10.1001/archderm.132.7.821

Cited by 5 publications

(2 citation statements)

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“…Whilst there are older publications indicating that other fungal infections have been found in Uganda, there are no data from Uganda related to the frequency of Candida bloodstream infection or intra‐abdominal abscess, fungal keratitis, chromoblastomycosis, mycetoma, histoplasmosis, blastomycosis or mucormycosis. Histoplasmosis certainly occurs in Uganda, as evidenced by occasional case reports .…”

Section: Resultsmentioning

confidence: 99%

Cryptococcal disease and the burden of other fungal diseases in Uganda; Where are the knowledge gaps and how can we fill them?

Parkes-Ratanshi

Achan

Kwizera

et al. 2015

Mycoses

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SummaryThe HIV epidemic in Uganda has highlighted Cryptococcus and Candida infections as important opportunistic fungal infections. However, the burden of other fungal diseases is not well described. We aimed to estimate the burden of fungal infections in Uganda. All epidemiological papers of fungal diseases in Uganda were reviewed. Where there is no Ugandan data, global or East African data were used. Recurrent vaginal candidiasis is estimated to occur in 375 540 Uganda women per year; Candida in pregnant women affects up to 651 600 women per year. There are around 45 000 HIV-related oral and oesophageal candidosis cases per year. There are up to 3000 cases per year of post-TB chronic pulmonary aspergillosis. There are an estimated 40 392 people with asthma-related fungal conditions. An estimated 1 300 000 cases of tinea capitis occur in school children yearly in Uganda. There are approximately 800 HIV-positive adults with Pneumocystis jirovecii pneumonia (PJP) annually and up to 42 000 children with PJP per year. There are an estimated 4000 cryptococcal cases annually. There are an estimated 2.5 million fungal infections per year in Uganda. Cryptococcus and PJP cause around 28 000 deaths in adults and children per year. We propose replicating the model of research around cryptococcal disease to investigate and development management strategies for other fungal diseases in Uganda.

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Section: Resultsmentioning

confidence: 99%

Cryptococcal disease and the burden of other fungal diseases in Uganda; Where are the knowledge gaps and how can we fill them?

Parkes-Ratanshi

Achan

Kwizera

et al. 2015

Mycoses

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“…Until 1964, blastomycosis was thought to be geographically restricted to North America. Since then, cases (autochthonous) that were verified to have originated in Africa (11,12), Central America, South America, the Middle East and Asia have been reported. Major endemic areas in North America are scattered mainly in the eastern half of the continent.…”

Section: Epidemiologymentioning

confidence: 99%

Blastomyscosis Acquired by Three Children in Toronto

Bernstein

Brunner²,

Summerbell³

et al. 2002

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Three paediatric cases of blastomycosis, apparently acquired in or near Toronto, Ontario, a region not known to be endemic for this disease, are described. Blastomycosis was not suspected clinically in any of the three cases, and the diagnosis was established only when the diagnostic net was broadened to include fungal and mycobacterial cultures. All three patients were diagnosed after significant delays, which is consistent with the rarity of the disease in children and its acquisition outside previously accepted geographical boundaries. Pulmonary involvement was present in all three children, while one also had multifocal osteomyelitis. Drug therapy was successful in all three cases, either with amphotericin B followed by itraconazole, or itraconazole alone. Blastomycosis should be included in the differential diagnosis of a patient from the Toronto area who presents with a compatible history despite a negative travel history to known endemic zones.

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Oral fungal and bacterial infections in HIV‐infected individuals: an overview in Africa

Hodgson

Rachanis

2002

Oral Diseases

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Oral opportunistic infections developing secondary to human immunodeficiency virus (HIV) infection have been reported from the early days of the epidemic and have been classified by both the EC-Clearinghouse and the World Health Organisation (WHO). Among the fungal infections, oral candidiasis, presenting in African HIV-infected patients has been sporadically documented. We review the literature with respect to candidal carriage, oral candidiasis prevalence and the predictive value of oral candidiasis for a diagnosis of underlying HIV disease in African HIV-infected patients. The use of oral candidiasis as a marker of disease progression, the species of yeasts isolated from the oral cavity in Africa and the resistance of the yeasts to antifungal agents and treatment regimens are discussed. Orofacial lesions as manifestations of the systemic mycoses are rarely seen in isolation and few cases are reported in the literature from Africa. In spite of the high incidence of noma, tuberculosis, chronic osteomyelitis and syphilis in Africa, surprisingly there have been very few reported cases of the oral manifestations of these diseases in HIV-positive individuals. Orofacial disease in HIV-infected patients is associated with marked morbidity, which is compounded by malnutrition. The authors indicate specific research areas, initially directed at the most effective management strategies, which would complete data in this important area.

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Widespread papules and nodules in a Ugandan man with acquired immunodeficiency syndrome. African blastomycosis

Cited by 5 publications

References 0 publications

Cryptococcal disease and the burden of other fungal diseases in Uganda; Where are the knowledge gaps and how can we fill them?

Cryptococcal disease and the burden of other fungal diseases in Uganda; Where are the knowledge gaps and how can we fill them?

Blastomyscosis Acquired by Three Children in Toronto

Oral fungal and bacterial infections in HIV‐infected individuals: an overview in Africa

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