Widespread Parallel Evolution in Sticklebacks by Repeated Fixation of Ectodysplasin Alleles

Colosimo, Pamela F.; Hosemann, Kim E.; Balabhadra, Sarita; Villarreal, Guadalupe; Dickson, Mark; Grimwood, Jane; Schmutz, Jeremy; Myers, R; Schluter, Dolph; Kingsley, David M.

doi:10.1126/science.1107239

Cited by 1,365 publications

(1,915 citation statements)

References 37 publications

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“…An illustrative example of what may happen during an environmental shift is the rare EDA allele present in oceanic populations of sticklebacks in a frequency of 1%. This allele is strongly favored in freshwater populations (frequency 100%) and is critical to the repeated development of locally adapted freshwater populations of sticklebacks (Colosimo et al 2005). Hence, less common and rare alleles contribute to the standing genetic variation of a population and although the majority of genes may be neutral or even slightly deleterious under present selection regimes, this variation may be critical to the population during adaptation to a new environment (Barrett and Schluter 2008).…”

Section: The Importance Of Genetic Variationmentioning

confidence: 99%

The Future of Baltic Sea Populations: Local Extinction or Evolutionary Rescue?

Johannesson

Smolarz

Grahn

et al. 2011

AMBIO

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Environmental change challenges local and global survival of populations and species. In a speciespoor environment like the Baltic Sea this is particularly critical as major ecosystem functions may be upheld by single species. A complex interplay between demographic and genetic characteristics of species and populations determines risks of local extinction, chances of re-establishment of lost populations, and tolerance to environmental changes by evolution of new adaptations. Recent studies show that Baltic populations of dominant marine species are locally adapted, have lost genetic variation and are relatively isolated. In addition, some have evolved unusually high degrees of clonality and others are representatives of endemic (unique) evolutionary lineages. We here suggest that a consequence of local adaptation, isolation and genetic endemism is an increased risk of failure in restoring extinct Baltic populations. Additionally, restricted availability of genetic variation owing to lost variation and isolation may negatively impact the potential for evolutionary rescue following environmental change.

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Section: The Importance Of Genetic Variationmentioning

confidence: 99%

The Future of Baltic Sea Populations: Local Extinction or Evolutionary Rescue?

Johannesson

Smolarz

Grahn

et al. 2011

AMBIO

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“…The three-spined stickleback, Gasterosteus aculeatus, is a highly adaptable teleost fish, ubiquitous throughout temperate regions of the Northern hemisphere. Their small size, widedistribution, short generation time and ease of care in captivity have made them a popular study species across a number of different disciplines including ecology, toxicology and molecular biology (Barber and Nettleship 2010; Katsiadaki et al 2007;Colosimo et al 2005). However, relatively little is known about how these fish respond to hypoxic stress.…”

Section: Introductionmentioning

confidence: 99%

The effects of acute and chronic hypoxia on cortisol, glucose and lactate concentrations in different populations of three-spined stickleback

O’Connor

Pottinger

Sneddon

2010

Fish Physiol Biochem

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Article (refereed)O'Connor, E.A.; Pottinger, T.G.; Sneddon, L.U.. 2011 The effects of acute and chronic hypoxia on cortisol, glucose and lactate concentrations in different populations of three-spined stickleback. Fish Physiology and Biochemistry, 37 (3). 461-469. 10.1007/s10695-010-9447-y Contact CEH NORA team at noraceh@ceh.ac.ukThe NERC and CEH trade marks and logos ('the Trademarks') are registered trademarks of NERC in the UK and other countries, and may not be used without the prior written consent of the Trademark owner. ABSTRACTThe response of individuals from three different populations of three-spined sticklebacks to acute and chronic periods of hypoxia (4.4 kPa DO, 2.2 mg l -1 ) were tested using measures of whole-body (WB) cortisol, glucose and lactate. Although there was no evidence of a neuroendocrine stress response to acute hypoxia, fish from the population least likely to experience hypoxia in their native habitat had the largest response to low oxygen, with significant evidence of anaerobic glycolysis after two hours of hypoxia. However, there was no measurable effect of a more prolonged period (seven days) of hypoxia on any of the fish in this study, suggesting that they acclimated to this low level of oxygen over time. Between-population differences in the analytes tested were observed in the control fish of the acute hypoxia trial, which had been in the laboratory for 16 days. However, these differences were not apparent among the control fish in the chronic exposure groups that had been held in the laboratory for 23 days suggesting that these site-specific trends in physiological status were acclimatory. Overall, the results of this study suggest that local environmental conditions may shape sticklebacks' general physiological profile as well as influencing their response to hypoxia. 2 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 Reduced dissolved oxygen (DO) in the water is an important environmental stressor for fish. Periods of low DO, or hypoxia, can occur as a result of many factors such as eutrophication, elevated ambient temperature and algal blooms. With climate-related warming of freshwater bodies predicted to continue (Bates et al. 2008;Johnson et al. 2009), a greater understanding of the response of fish species to consequent environmental factors such as hypoxia could prove beneficial (Gitay et al. 2002). The three-spined stickleback, Gasterosteus aculeatus, is a highly adaptable teleost fish, ubiquitous throughout temperate regions of the Northern hemisphere. Their small size, widedistribution, short generation time and ease of care in captivity have made them a popular study species across a number of different disciplines including ecology, toxicology and molecular biology (Barber and Nettleship 2010; Katsiadaki et al. 2007;Colosimo et al. 2005). However, relatively little is known about how these fish respond to hypoxic stress.Previous studies indicate that the three-...

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“…A TNF has been cloned and characterized in many fish species and has been found to be similar to mammalian TNF-␣ (TNFSF2) (5)(6)(7)(8)(9)(10). Other genes that have been characterized in teleosts include a TRAIL-like (11), EDA (12), and BAFF (TNFSF13b) genes (G. D. Wiens, S. Gahr, F. Rodriguez, Y. Palti, C. Rexroad, and G. Glenney, manuscript in preparation). A homolog of mammalian LT-␣ (TNFSF1) has not been described in fish and has been suggested to not exist (13).…”

mentioning

confidence: 99%

Early Diversification of the TNF Superfamily in Teleosts: Genomic Characterization and Expression Analysis

Glenney

Wiens

2007

The Journal of Immunology

109

121

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The TNF superfamily (TNFSF) of proteins are cytokines involved in diverse immunological and developmental pathways. Little is known about their evolution or expression in lower vertebrate species. Bioinformatic searches of Zebrafish, Tetraodon, and Fugu genome and other teleost expressed sequence tag databases identified 44 novel gene sequences containing a TNF homology domain. This work reveals the following: 1) teleosts possess orthologs of BAFF, APRIL, EDA, TWEAK, 4-1BBL, Fas ligand, LIGHT, CD40L, RANKL, and possibly TL1A; 2) the BAFF-APRIL subfamily is enriched by a third member, BALM, unique to fish; 3) orthologs of lymphotoxins ␣ and ␤ were not clearly identified in teleosts and are substituted by a related ligand, TNF-New; 4) as many as four TRAIL-like genes are present in teleosts, as compared with only one in mammals; and 5) T cell activation ligands OX40L, CD27L, CD30L, and GITRL were not identified in any fish species. Finally, we characterize mRNA expression of TNFSF members CD40L, LIGHT, BALM, APRIL, Fas ligand, RANKL, TRAIL-like, and TNF-New in rainbow trout, Oncorhynchus mykiss, immune and nonimmune tissues. In conclusion, we identified a total of 14 distinct TNFSF members in fishes, indicating expansion of this superfamily before the divergence of bony fish and tetrapods, ϳ360 -450 million years ago. Based on these findings, we extend a model of TNFSF evolution and the coemergence of the vertebrate adaptive immune system.

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Widespread Parallel Evolution in Sticklebacks by Repeated Fixation of Ectodysplasin Alleles

Cited by 1,365 publications

References 37 publications

The Future of Baltic Sea Populations: Local Extinction or Evolutionary Rescue?

The Future of Baltic Sea Populations: Local Extinction or Evolutionary Rescue?

The effects of acute and chronic hypoxia on cortisol, glucose and lactate concentrations in different populations of three-spined stickleback

Early Diversification of the TNF Superfamily in Teleosts: Genomic Characterization and Expression Analysis

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