Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis

Kňazovický, Dávid; Helgeson, Erika S.; Case, Beth; Gruen, Margaret E.; Maixner, William; Lascelles, B. Duncan X.

doi:10.1097/j.pain.0000000000000521

Cited by 72 publications

(88 citation statements)

References 51 publications

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“…Quantitative sensory testing (QST), a method of quantifying pain, has been used to demonstrate central sensitization in human OA 182,183 , experimental dog OA 184 and spontaneous dog OA 185 . QST has also been used to demonstrate the efficacy of dog total hip replacements for reversing hyperalgesia 186 , as occurs in humans 187 .…”

Section: A Means To Identify the Genetic Basis Of Analogous Diseasementioning

confidence: 99%

Spontaneous dog osteoarthritis — a One Medicine vision

et al. 2019

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| Osteoarthritis (OA) is a global disease that, despite extensive research, has limited treatment options. Pet dogs share both an environment and lifestyle attributes with their owners, and a growing awareness is developing in the public and among researchers that One Medicine, the mutual co-study of animals and humans, could be beneficial for both humans and dogs. To that end, this Review highlights research opportunities afforded by studying dogs with spontaneous OA , with a view to sharing this active area of veterinary research with new audiences. Similarities and differences between dog and human OA are examined, and the proposition is made that suitably aligned studies of spontaneous OA in dogs and humans, in particular hip and knee OA , could highlight new avenues of discovery. Developing cross-species collaborations will provide a wealth of research material and knowledge that is relevant to human OA and that cannot currently be obtained from rodent models or experimentally induced dog models of OA. Ultimately , this Review aims to raise awareness of spontaneous dog OA and to stimulate discussion regarding its exploration under the One Medicine initiative to improve the health and well-being of both species.

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Section: A Means To Identify the Genetic Basis Of Analogous Diseasementioning

confidence: 99%

Spontaneous dog osteoarthritis — a One Medicine vision

et al. 2019

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“…Mechanical stimuli include touch, pressure, and vibration, and the information is transmitted through mechanoreceptors in the skin and travels along myelinated axons through the dorsal column‐medial lemniscal pathway. Commonly, von Frey filaments have been used in humans with SM15, 16 and in various studies of pain in dogs 23, 25, 26, 27, 28, 29, 32, 33. The use of von Frey mechanical testing has been found to be feasible and reliable31, 33 and in 1 study identified different thresholds in normal dogs compared to dogs with acute spinal cord injury 32.…”

Section: Discussionmentioning

confidence: 99%

“…Thermal testing also has been used in humans15, 16, 17, 35 and dogs23, 24, 25, 26, 29 to evaluate neuropathic and chronic pain. Temperature and pain stimuli are carried by nonmyelinated C fibers through the spinothalamic pathway.…”

Section: Discussionmentioning

confidence: 99%

“…Questionnaire tools completed by owners have been developed,8, 19, 20, 21 but more objective quantification using QST is lacking. Thermal and mechanical testing has been shown to be reliable and discriminatory in dogs with other pain disorders 22, 23, 24, 25, 26, 27, 28, 29. Our main objective was to use thermal and mechanical stimuli to quantify sensory thresholds in a cohort of CKCS and to compare sensory thresholds in dogs with and without SM.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari‐like malformations and syringomyelia

Sparks

Gorney

Williams

et al. 2018

Veterinary Internal Medicne

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BackgroundCavalier King Charles Spaniels (CKCS) suffer pain associated with Chiari‐like malformation and syringomyelia (CMSM). People suffer from a similar condition and describe numerous sensory abnormalities. Sensory changes have not been quantified in affected CKCS.ObjectivesTo use quantitative sensory testing (QST) to quantify thermal and mechanical thresholds in CKCS and to compare QST in dogs with and without syringomyelia (SM).AnimalsForty‐four CKCS.MethodsProspective study. Dogs underwent neurological examinations and craniocervical magnetic resonance imaging (MRI). Thermal testing was performed over the humerus and thorax (n = 32); mechanical testing was performed on the paw and neck (n = 44). Latencies, thresholds, and response rates were compared with presence and severity of SM on MRI, presence of pain reported by the owner and pain identified on examination.ResultsThirty dogs had SM, 30 were painful on examination, 29 were owner‐reported symptomatic. Thermal and mechanical variables were not significantly different based on presence or severity of SM. Dogs with pain on examination had decreased mechanical thresholds on the paw (0.38 kg, SD = 0.18) and neck (2.05 kg, SD = 0.74) compared to thresholds of dogs without pain on examination on the paw (0.60 kg, SD = 0.30) and neck (2.72 kg, SD = 0.57; P = .021).Conclusions and Clinical ImportanceMechanical and thermal sensitivity does not appear to be related to the presence of SM, but mechanical sensitivity appears to be related to the presence of pain and clinical signs. Mechanical testing may be useful for assessing sensory abnormalities during clinical trials.

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“…Utilizing veterinary patients can potentially bridge the gap between studies in preclinical laboratory animal models and human clinical trials, leading to proof of efficacy and benefits for the veterinary population, as well as providing a "pathway" for drugs and procedures to be further studied in humans. 53 In the veterinary clinical population there are many patients that provide excellent examples of a naturally occurring disease where intervention may be very similar to those in human patients, including osteoarthritis (OA) 54 and bone cancer. 55 A challenge in this regard is that even within a disease category such as OA, there may be significant differences between species in terms of disease onset (acute or chronic), progression (weeks versus months), onset of clinical symptoms versus when the disease began, etc.…”

Section: Veterinary Clinical Trials As a Bridge Between Preclinical Lmentioning

confidence: 99%

Ethical use of animal models in musculoskeletal research

Allen

Hankenson

Goodrich

et al. 2017

Journal Orthopaedic Research

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The use of animals in research is under increasing scrutiny from the general public, funding agencies, and regulatory authorities. Our ability to continue to perform in-vivo studies in laboratory animals will be critically determined by how researchers respond to this new reality. This Perspectives article summarizes recent and ongoing initiatives within ORS and allied organizations to ensure that musculoskeletal research is performed to the highest ethical standards. It goes on to present an overview of the practical application of the 3Rs (reduction, refinement, and replacement) into experimental design and execution, and discusses recent guidance with regard to improvements in the way in which animal data are reported in publications. The overarching goal of this review is to challenge the status quo, to highlight the absolute interdependence between animal welfare and rigorous science, and to provide practical recommendations and resources to allow clinicians and scientists to optimize the ways in which they undertake preclinical studies involving animals. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:740-751, 2017.

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Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis

Abstract: Supplemental Digital Content is Available in the Text.

Cited by 72 publications

References 51 publications

Spontaneous dog osteoarthritis — a One Medicine vision

Spontaneous dog osteoarthritis — a One Medicine vision

Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari‐like malformations and syringomyelia

Ethical use of animal models in musculoskeletal research

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