Objectivewidowhood is one of the inevitable challenges of aging, which may affect the quality of life. If the widow is in a good relationship with relatives and friends, the possibility of exposition to the damage caused by widowhood is decreased. Hence, the present study has been conducted to determine the relationship between quality of relationships and quality of life of elderly widows in northeastern Iran.Materials & Methodsthe descriptive-analytical study in kind of cross-sectional design was done on 1456 widows in northeastern ran in 2021. The sampling in this study was done using proportional stratified random sampling. The data collection instrument included three questionnaires of demographic information, Quality of Relationships Inventory (QRI), and Elderly Quality of Life (QoL) Questionnaire (LIPAD). Data analysis was done using SPSS-25, and Amos-21.Results75.9% of elderly widows were suffering from types of chronic diseases. 82.7% of widows were illiterate. The results of this study showed that the quality of relationships can have a significant effect on the quality of life of elderly widows (effect size≥0.30). Conclusionas it is proved that social support is an underlying indicator in health-related quality of life, the negative effects of widowhood on the quality of life can be reduced by making supporting family and social relationships.