In this article, a real-time block-oriented identification method for nonlinear multiple-input-multiple-output systems with input time delay is proposed. The proposed method uses the Wiener structure, which consists of a linear dynamic block (LDB) followed by a nonlinear static block (NSB). The LDB is described by the Laguerre filter lattice, whereas the NSB is characterized using the neural networks. Due to the online adaptation of the parameters, the proposed method can cope with the changes in the system parameters. Moreover, the convergence and bounded modeling error are shown using the Lyapunov direct method. Four practical case studies show the effectiveness of the proposed algorithm in the open-loop and closed-loop identification scenarios. The proposed method is compared with the recently published methods in the literature in terms of the modeling accuracy, parameter initialization, and required information from the system. How to cite this article: Sadeghi M, Farrokhi M. Real-time identification of nonlinear multiple-inputmultiple-output systems with unknown input time delay using Wiener model with Neuro-Laguerre structure. Int J Adapt Control Signal Process. 2019;33:157-174. https://doi.