This chapter explores the integration of artificial intelligence (AI) and internet of things (IoT) technologies in autonomous systems. AI plays a crucial role in decision-making, predictive analytics, and adaptive learning, while IoT's sensor networks enable real-time data acquisition, communication, and control mechanisms. The integration of AI and IoT is explored across sectors like predictive maintenance, smart city infrastructure, healthcare, and industrial automation. However, challenges such as increasing reliance on edge computing, enhancing AI efficiency, stringent data security measures, and ethical considerations are highlighted. The chapter emphasizes the need for resilient, secure, and ethical advancements in technology to harness the potential of AI-infused autonomous systems and IoT technologies.