Wild black rats (Rattus rattus Linnaeus, 1758) as zoomonitor of genotoxicity and systemic toxicity induced by hazardous emissions from Abule Egba unsanitary landfill, Lagos, Nigeria

Alimba, Chibuisi G.; Adewumi, O. O.; Binuyo, Olufisayo M; Odeigah, P. G. C.

doi:10.1007/s11356-020-11325-7

Cited by 18 publications

(16 citation statements)

References 69 publications

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“…In Nigeria, solid wastes which usually serve as substrates for wild mushroom growth, contain mixtures of electronic wastes, hospital wastes, municipal wastes, industrial wastes and agricultural wastes [82,83]. These wastes which are metal-laden are indiscriminately co-disposed in the Nigerian environment [84,85,86]. Since the spores from mushrooms (fungi) are airborne, the solid wastes provide good environment for their germination and growth.…”

Section: Risk Assessment To Human Health From the Consumption Of Meta...mentioning

confidence: 99%

Carcinogenic and non-carcinogenic risk assessment of consuming metal-laden wild mushrooms in Nigeria: Analyses from field based and systematic review studies

Chukwuka,

Adesida,

Alimba

2023

Environ Anal Health Toxicol

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This study investigated the potential health risk associated with the consumption of metal-laden mushrooms in Nigeria. Concentrations of Pb, Cd, Cr, Cu, Ni, Zn and Al in wild mushrooms collected from the Nigerian environment were measured using atomic absorption spectrometer. Also, systematic analysis of articles on metal accumulation in mushrooms from Nigeria were obtained from scientific databases. Using hazard model indices, the metal concentration in mushrooms were evaluated for their potential carcinogenic and non-carcinogenic health risk when consumed by adults and children. Zn and Cd, respectively, had the highest and lowest mean concentrations (mg kg-1) in the analysed mushrooms from the field study, while Fe and Co, respectively, had the highest and lowest mean concentrations (mg kg-1) in the systematically reviewed articles. In the field study, the percentage distribution of THQ of the heavy metals greater than 1 was 0% and 42.85% for adults and children respectively. While for the systematic study, 30% and 50% of the heavy metals for adults and children respectively exceeded the limit of 1. The hazard indices obtained from both the systematic and field studies for both age groups were all >1, indicating significant health risk. The findings from both the systematic and field studies revealed that consuming metal-laden mushrooms by adults and children increases the carcinogenic risk to Cd, Cr, and Ni since they exceeded the acceptable limit of 1E-04 stated by USEPA guideline. Based on the findings from the systematic and field studies, it suggests that consuming mushrooms collected from metal polluted substrates increases carcinogenic and non-carcinogenic health risk among Nigerians.

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Section: Risk Assessment To Human Health From the Consumption Of Meta...mentioning

confidence: 99%

Carcinogenic and non-carcinogenic risk assessment of consuming metal-laden wild mushrooms in Nigeria: Analyses from field based and systematic review studies

Chukwuka,

Adesida,

Alimba

2023

Environ Anal Health Toxicol

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“…Anthropogenic activities in industries, agriculture, medicine, municipality and educational institutions generate solid wastes, which are capable of releasing several thousands of chemicals into the environment [1,2]. Disposal of solid wastes generated from anthropogenic activities into the environment is increasing around the globe at alarming rate.…”

Section: Introductionmentioning

confidence: 99%

“…In some parts of the world, most importantly in developing countries, solid wastes are indiscriminately disposed into unsanitary landfills, combusted in open canals along major roads, and illegally disposed into sea and water ways and other parts of the environment [1,3]. These awkward methods of disposing solid wastes have elicited strong national and international concerns due to contamination of the environmental metrices (air, soil, surface and underground water and biota of the ecosystem) and health risks associated with living within the vicinity of these wastes [1][2][3][4]. Landfilling is the most common method of managing solid wastes all over the world.…”

Section: Introductionmentioning

confidence: 99%

“…It accounts for the management of about 95% of the total solid waste collection worldwide [5]. In Nigeria and most other developing nations, landfills are unsanitary; usually unlined and are located in public places surrounded by residential quarters and in wetland or other places with seasonally high-water tables [1,2,6]. This disposal method is capable of releasing chemicals in the forms of gases and or liquid solutions called leachates, into the environment and can endanger the survival of wildlife and humans [1,2,7].…”

Section: Introductionmentioning

confidence: 99%

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Alterations in viscera histoarchitecture and organosomatic index as biomarkers of toxicity induced by Aba-Eku and Olusosun solid waste landfill leachates in Rattus norvegicus

Alimba

2024

Environ Anal Health Toxicol

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Solid waste disposal generates leachate, a mixture of deleterious chemical, physical and microbial contaminants, which poses risk to human and wildlife health. Leachate toxicity on relative organ weight and histopathology of important viscera in mammalian body is scarce. Leachate induced toxic effects on organosomatic indices and histopathology of vital mammalian organs were investigated. Wister rats were orally exposed to 1 – 25 % of raw and simulated leachates from Aba-Eku and Olusosun landfills for 30 days. At post-exposure, organosomatic index and histoarchitectural assessment of major viscera (heart, spleen, thymus and lungs) were conducted. The physico-chemical and organic compositions of the leachates were analysed using standard protocol. The tested leachates decreased weekly and terminal body weights, and altered organosomatic index of examined viscera in rats. The histoarchitecture of the investigated viscera revealed pathologies that ranged from mild to severe degeneration, cellular infiltration, haemorrhage, congestion, necrosis, disorganization of tissues and vacuolations. Others include increased histiocytes within the bronchial associated lymphoid, lymphoid depletions, haemosiderin deposits and apoptosis were observed in the examined viscera. Physico-chemical analysis of the leachates showed different concentrations of toxic metals, PAHs and PCBs that were higher than national and international permissible limits allowed in wastewaters. The physico-chemical compositions of the leachates are capable of eliciting the observed alterations in organosomatic indices and histopathological lesions in mammalian viscera. Xenobiotic components of the leachates possibly generated free radicals and/or directly disrupted the organ architectures. These findings suggest health risk to wildlife and human population exposed to emissions from waste landfills.

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“…Renal toxicity from cadmium exposure is correlated with the number of cadmium ions in kidney tubule cells, reabsorption, degradation of cadmium metallothionein complexes, and excess production of metallothionein by renal tubules ( Davenport, 2020 ; Zavala-Guevara et al, 2021 ). Cadmium toxicity observed in the renal cortex of laboratory rats ( Rattus rattus ) resulted in cytosolic damage and renal malfunction after oral administration of cadmium chloride (CdCl 2 ) ( Alimba et al, 2021 ; Hashim et al, 2018 ; Siddiqui, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Using Peromyscus leucopus as a biomonitor to determine the impact of heavy metal exposure on the kidney and bone mineral density: results from the Tar Creek Superfund Site

Elturki

2022

PeerJ

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Background Human population growth and industrialization contribute to increased pollution of wildlife habitats. Heavy metal exposure from industrial and environmental sources is still a threat to public health, increasing disease susceptibility. In this study, I investigated the effects of heavy metals (cadmium (Cd), lead (Pb), and zinc (Zn)) on kidney and bone density. Objective This study aims to determine the concentrations of Cd, Pb, and Zn in soil and compare them to the levels of the same metals in Peromyscus leucopus kidney tissue. Furthermore, the study seeks to investigate the impact of heavy metals on bone density and fragility using the fourth lumbar vertebra (L4) of P. leucopus. Methods Cd, Pb, and Zn concentrations in soil specimens collected from Tar Creek Superfund Site (TCSFS), Beaver Creek (BC), and two reference sites (Oologah Wildlife Management Area (OWMA) and Sequoyah National Wildlife Refuge (SNWR)). Heavy metal concentrations were analyzed using inductively coupled plasma-mass spectroscopy (ICP-MS). Micro-computed tomography (µCT) was used to assess the influence of heavy metals on bone fragility and density. Results On the one hand, soil samples revealed that Pb is the most common pollutant in the sediment at all of the investigated sites (the highest contaminated site with Pb was TCSFS). Pb levels in the soil of TCSFS, BC, OWMA, and SNWR were found to be 1,132 ± 278, 6.4 ± 1.1, and 2.3 ± 0.3 mg/kg in the soil of TCSFS, BC and OWMA and SNWR, respectively. This is consistent with the fact that Pb is one of the less mobile heavy metals, causing its compounds to persist in soils and sediments and being barely influenced by microbial decomposition. On the other hand, the kidney samples revealed greater Cd levels, even higher than those found in the soil samples from the OWMA and SNWR sites. Cd concentrations in the kidney specimens were found to be 4.62 ± 0.71, 0.53 ± 0.08, and 0.53 ± 0.06 µg/kg, respectively. In addition, micro-CT analysis of L4 from TCSFS showed significant Pearson’s correlation coefficients between Cd concentrations and trabecular bone number (−0.67, P ≤ 0.05) and trabecular separation (0.72, P ≤ 0.05). The results showed no correlation between bone parameters and metal concentrations at reference sites. This study is one of the few that aims to employ bone architecture as an endpoint in the field of biomonitoring. Furthermore, this study confirmed some earlier research by demonstrating substantial levels of heavy metal contamination in soil samples, kidney samples, and P. leucopus L4 trabecular bone separations from TCSFS. Moreover, this is the first study to record information regarding bone microarchitecture parameters in P. leucopus in North America.

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Wild black rats (Rattus rattus Linnaeus, 1758) as zoomonitor of genotoxicity and systemic toxicity induced by hazardous emissions from Abule Egba unsanitary landfill, Lagos, Nigeria

Cited by 18 publications

References 69 publications

Carcinogenic and non-carcinogenic risk assessment of consuming metal-laden wild mushrooms in Nigeria: Analyses from field based and systematic review studies

Carcinogenic and non-carcinogenic risk assessment of consuming metal-laden wild mushrooms in Nigeria: Analyses from field based and systematic review studies

Alterations in viscera histoarchitecture and organosomatic index as biomarkers of toxicity induced by Aba-Eku and Olusosun solid waste landfill leachates in Rattus norvegicus

Using Peromyscus leucopus as a biomonitor to determine the impact of heavy metal exposure on the kidney and bone mineral density: results from the Tar Creek Superfund Site

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