1993
DOI: 10.1016/0960-0760(93)90336-u
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Wild type and alternatively spliced estrogen receptor messenger RNA in human meningioma tissue and MCF7 breast cancer cells

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Cited by 58 publications
(22 citation statements)
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“…In some samples (CNTFR, ER and IL-6R) a smaller hybridising PCR product was identi®ed. These bands were attributed to alternative splicing (Koehorst et al, 1993;Horiuchi et al, 1994) This was in striking contrast to infrequent and sporadic expression of other members of the cytokine receptor superfamily such as G ± CSFR, IL-7R, GM ± CSFb (analogous to gp130 in that it is shared by GM ± CSF, IL-3 and IL-5) or IL-2Rg (shared by IL-2, 4, 7, 9 and 13). A detailed study of the ligands for many of these growth factors failed to demonstrate an action on breast cancer cells (Emerman and Eaves, 1994).…”
Section: Discussionmentioning
confidence: 99%
“…In some samples (CNTFR, ER and IL-6R) a smaller hybridising PCR product was identi®ed. These bands were attributed to alternative splicing (Koehorst et al, 1993;Horiuchi et al, 1994) This was in striking contrast to infrequent and sporadic expression of other members of the cytokine receptor superfamily such as G ± CSFR, IL-7R, GM ± CSFb (analogous to gp130 in that it is shared by GM ± CSF, IL-3 and IL-5) or IL-2Rg (shared by IL-2, 4, 7, 9 and 13). A detailed study of the ligands for many of these growth factors failed to demonstrate an action on breast cancer cells (Emerman and Eaves, 1994).…”
Section: Discussionmentioning
confidence: 99%
“…This variant was constitutively active in a trans-activation assay . We detected in meningiomas two variant ER mRNA species (Koehorst et al, 1993). One variant with a major deletion in the ligand binding domain was an alternatively spliced product missing exon 7.…”
mentioning
confidence: 88%
“…Apart from the wild type (wt) mRNA we also found two alternatively spliced mRNA's. One variant is missing exon 4 and the other is missing exon 7 (Koehorst et al, 1993).…”
mentioning
confidence: 99%
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“…A similar observation was made for endometrial carcinomas (Nyholm et al, 1995) who suggested that sub-populations of ER may bind oestradiol while being unable to react with the Abbott MAbs. A number of variant exon-deleted forms of ER have been described (McGuire et al, 1991) including one in which exon 4 is missing (Koehorst et al, 1993;Pfeffer et al, 1993). This would result in loss of the epitope for recognition by the Abbott D547 antibody, while sufficient of the hormone-binding domain would be retained to permit binding of oestradiol.…”
Section: Discussionmentioning
confidence: 99%