WILDER PENFIELD, PíO DEL RíO-Hortega, AND THE DISCOVERY OF OLIGODENDROGLIA

Gill, Amandip S; Binder, Devin K.

doi:10.1227/01.neu.0000255448.97730.34

Cited by 29 publications

(24 citation statements)

References 20 publications

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“…Afterward, these glial cells were named ''astrocytes'' by Lenhosse'k (Stahnisch and Bulloch 2011). In the 1920s, Cajal and colleagues identified two other main classes of glial cells which represented oligodendrocytes and microglia (Gill and Binder 2007;Sotelo 2003). From the traditional perspective, neuroglial cells only regulate brain homeostasis and protect neural cells against pathological insults ).…”

Section: Introductionmentioning

confidence: 99%

Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer’s disease

et al. 2016

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It is increasingly recognized that astrocytes and microglia-associated dysfunction contribute to AD pathology. In addition, glial nicotinic acetylcholine receptors (nAChRs) play a role in AD-related phenomena, such as neuron survival, synaptic plasticity, and memory. From mechanistic point of view, the glial regulation of pro-inflammatory cytokines, as common contributors in AD, is modulated by nAChRs. Astrocytic and microglial nAChRs contribute to Aβ metabolism, including Aβ phagocytosis and degradation as well as Aβ-related oxidative stress and neurotoxicity. These receptors are also involved in neurotransmission and gliotransmission through indirect interaction with N-Methyl-D-aspartate (NMDA) and a-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA) receptors as well as gamma-aminobutyric acid (GABA) and intracellular calcium regulation. In addition, glial nAChRs participate in trophic factors-induced neuroprotection. This review gathers the most recent advances along with the previous data on astrocytic and microglial nAChRs role in AD pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer’s disease

et al. 2016

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“…Penfield subsequently received his MD from Johns Hopkins in 1918, and then trained in surgery and neurosurgery in Boston for one year with Harvey Cushing. He returned to Oxford in 1919 to work again in Sherrington's neurophysiology laboratory for two years 29 . He also spent time with J. Godwin Greenfield, the preeminent English neuro-pathologist, whom Penfield regarded as a "clinical pathologist, rather than a cytologist aloof from bedside problems" 30 .…”

Section: Development Of Neuropathology In Montréal 1930s-1950smentioning

confidence: 99%

“…Prior to the move, Penfield returned to Europe to study surgical resection of epileptogenic brain scars with Otfrid Foerster in Breslau, Germany, and to study neuropathology and neuroanatomy with Cecile and Oskar Vogt in Berlin for six months. He also met Dorothy Russell, the English pathologist who was to gain renown for her work on brain tumours 29,31 . At that time he solidified his concept for a textbook on neuropathology.…”

Section: Development Of Neuropathology In Montréal 1930s-1950smentioning

confidence: 99%

Neuropathology in Canada: The First One Hundred Years

Bigio

Rewcastle

2010

Can. j. neurol. sci.

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We describe the evolution of neuropathology in Canada, beginning with William Osler who began working in Montréal in 1874 and finishing with the major period of expansion in the 1970s. Organized services began in the 1930s, in Montréal with the neurosurgeons Wilder Penfield and William Cone, and in Toronto with Eric Linell and Mary Tom, who both began their careers as neuroanatomists. Jerzy Olszewski and Gordon Mathieson, who trained in Montréal and Toronto, drove the creation of the CanadianAssociation of Neuropathologists in 1960. Training guided by the Royal College of Physicians and Surgeons of Canada was formalized in 1965, with the first certifying examination in 1968 and the subsequent creation of formal structured training programs. The number of neuropathologists in Canada increased rapidly through the 1960s and 1970s, with individuals coming from both clinical neuroscience and anatomic pathology backgrounds, a pattern that persists to the present day.

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“…A group of like-minded histologists who made other discoveries formed around Cajal (41). Among these was Pío del Río-Hortega, who first described microglia and oligodendroglia (42). Hortega's silver carbonate method for astrocytes (1918) uses the same FAB fixation, followed by an ammoniacal silver nitrate-lithium carbonate solution.…”

Section: Neurogliamentioning

confidence: 99%

“…Hortega's silver carbonate method for astrocytes (1918) uses the same FAB fixation, followed by an ammoniacal silver nitrate-lithium carbonate solution. After several steps, the astrocytes are seen as black (42).…”

Section: Neurogliamentioning

confidence: 99%

Progress in the Development of Microscopical Techniques for Diagnostic Pathology

Titford¹

2009

Journal of Histotechnology

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Many of the time-honored methods for histopathological analysis of tissue sections have been superseded by new histological techniques, immunohistochemistry, or other diagnostic tests. Some of the dyes that were used for generations are no longer available, and chemicals used in some older methods are now considered hazardous. Additionally, the histotechnologists and pathologists familiar with these techniques are now retiring and leaving the field, resulting in a loss of experience. To provide a sense of the rich legacy of histopathological analysis, this article reviews the development of special stains in histopathology, describes staining techniques, and discusses the wide range of applications. Numerous staining techniques mentioned in this article were originally published many years ago, some in obscure journals in foreign countries, and are not readily available to practicing histotechnologists. To encourage further study, references in English are given, many to popular histotechnology texts found in most histopathology laboratories or biomedical libraries. ( The J Histotechnol 32(1):9-

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WILDER PENFIELD, PíO DEL RíO-Hortega, AND THE DISCOVERY OF OLIGODENDROGLIA

Cited by 29 publications

References 20 publications

Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer’s disease

Astrocytic and microglial nicotinic acetylcholine receptors: an overlooked issue in Alzheimer’s disease

Neuropathology in Canada: The First One Hundred Years

Progress in the Development of Microscopical Techniques for Diagnostic Pathology

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