Will helminth co-infection modulate COVID-19 severity in endemic regions?

Bradbury, Richard S.; Piedrafita, David; Greenhill, Andrew R.; Mahanty, Siddhartha

doi:10.1038/s41577-020-0330-5

Cited by 76 publications

(73 citation statements)

References 6 publications

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“…In a very recent paper, Bradbury et al, suggested that immune modulation by helminths could reduce the human resistance to SARS CoV-2 infection. Nevertheless, they called upon the research community to investigate whether helminth co-infection with COVID-19 could influence the pandemic spread through the helminth endemic regions of the world (25). Here, contrary to the opinion by Bradbury et al, we argue that helminth coinfection, in conjunction with at least part of the factors mentioned above, may be related to the low lethality of COVID-19 in SSA.…”

contrasting

confidence: 63%

COVID-19 Lethality in Sub-Saharan Africa and Helminth Immune Modulation

et al. 2020

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contrasting

confidence: 63%

COVID-19 Lethality in Sub-Saharan Africa and Helminth Immune Modulation

et al. 2020

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“…However, immune responses to pulmonary coronaviruses and murid herpesvirus 4 are different, and therefore, the impact of helminth coinfection is yet to be determined. This is particularly important as the pandemic is now spreading through the helminth‐endemic regions of the word 70 …”

Section: Section 2: Immunology Of Covid‐19mentioning

confidence: 99%

A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2

Riggioni

Comberiati

Giovannini

et al. 2020

Allergy

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In December 2019, China reported the first cases of the coronavirus disease 2019 (COVID-19). This disease, caused by the severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), has developed into a pandemic. To date, it has resulted in ~9 million confirmed cases and caused almost 500 000 related deaths worldwide. Unequivocally, the COVID-19 pandemic is the gravest health and socioeconomic crisis of our time. In this context, numerous questions have emerged in demand of basic scientific information and evidence-based medical advice on SARS-CoV-2 and COVID-19. Although the majority of the patients show a very mild, self-limiting viral respiratory disease, many clinical manifestations in severe patients are unique to COVID-19, such as severe lymphopenia and eosinopenia, extensive pneumonia, a "cytokine storm" leading to acute respiratory distress syndrome, endothelitis, | 2505 RIGGIONI et al.

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“…In their recently published commentary, Bradbury and colleagues [ 1 ] drew attention to the possible negative interactions between helminth infection and COVID-19 severity in helminth-endemic regions. Helminth infections are known to be powerful modulators of the human immune response, and numerous studies now highlight the effects this may have on human infectious, inflammatory, and metabolic diseases.…”

mentioning

confidence: 99%