2020
DOI: 10.3389/fimmu.2020.571481
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Will SARS-CoV-2 Infection Elicit Long-Lasting Protective or Sterilising Immunity? Implications for Vaccine Strategies (2020)

Abstract: In December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) in Wuhan, China resulted in the current COVID-19 global pandemic. The human immune system has not previously encountered this virus, raising the important question as to whether or not protective immunity is generated by infection. Growing evidence suggests that protective immunity can indeed be acquired post-infection—although a handful of reinfection cases have been reported. However, it is still unknown whether the immune response to SARS-CoV… Show more

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Cited by 54 publications
(60 citation statements)
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References 172 publications
(299 reference statements)
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“…In addition to antibodies, CD4 T cells and CD8 T cells can provide protective roles in controlling SARS-CoV-2 infection 64,65 , with T cell immunity potentially being more enduring, as in the case of SARS-CoV 32,66 . In keeping with the published literature, we detected T cell responses via IFNγ-ELISpot in the majority of HIV positive and negative donors.…”
Section: Discussionmentioning
confidence: 99%
“…In addition to antibodies, CD4 T cells and CD8 T cells can provide protective roles in controlling SARS-CoV-2 infection 64,65 , with T cell immunity potentially being more enduring, as in the case of SARS-CoV 32,66 . In keeping with the published literature, we detected T cell responses via IFNγ-ELISpot in the majority of HIV positive and negative donors.…”
Section: Discussionmentioning
confidence: 99%
“…The antibody response was tested by DiaSorin's LIAISON -CLIA-S1/S2 R IgG solution (Saluggia, Italy) 3 . The choice of an assay targeting S protein was based on previous observation of other epidemic coronaviruses, showing that S protein was highly immunogenic and induced an immune response that was likely to be protective 4 . The antibody response was tested at the first outpatient visit (T1) set at week 12th ( ± 3 weeks) after symptoms onset (defined as 2 weeks, average time of clinical course, followed by 2 weeks of quarantine according to public health policy and 8 weeks of follow-up).…”
Section: Letter To the Editormentioning
confidence: 99%
“…An easing back of safety precautions may, unfortunately, coincide with the rise of variants whose risks surpass those of the original strains. And although vaccination is thought to prevent serious illness and death secondary to COVID-19, the effect of vaccination on transmission of severe acute respiratory syndrome coronavirus 2 is still unclear—meaning asymptomatic spread may be possible from vaccinated individuals ( 9 ). The cognitive biases that drive risk compensation are thus functioning with outdated and faulty information.…”
mentioning
confidence: 99%