The US Preventive Services Task Force (USPSTF) has published an updated recommendation statement on behavioral counseling interventions to promote a healthy diet and physical activity for cardiovascular disease (CVD) prevention in adults without CVD risk factors 1 and an updated evidence report and systematic review. 2 The USPSTF recommends that clinicians individualize the decision to offer or refer adults without CVD risk factors to behavioral counseling interventions to promote a healthy diet and physical activity (C recommendation.)As the USPSTF indicated, CVDs, including coronary heart disease and stroke, remain the leading cause of mortality in the US for male and female individuals and most races and ethnicities, including Black, Hispanic, and White adults. 2 Over the past 5 decades, there have been significant declines in physical activity, with corresponding marked increases in obesity and cardiometabolic diseases. 3,4 Certainly, efforts to reverse these trends are desperately needed.In the updated evidence report and systematic review, Patnode et al 2,5 included 113 randomized clinical trials (129 993 participants), 33 of which were published since the 2017 statement. Behavioral interventions improved participants' dietary intake and physical activity levels and provided very modest, but statistically significant, reductions in blood pressure, low-density lipoprotein cholesterol, and adiposity-related indices at 6 to 18 months of follow-up vs control conditions. Limitations of the review included few data on the underlying CVD risk of the populations studied, interventions that were primarily conducted in or applicable to primary care settings, the inability to directly assess the relationship between dietary patterns, physical activity levels, and health outcomes and heterogeneity with respect to clinical and demographic characteristics, counseling interventions, settings, and behavioral outcomes. Scarce studies reported on CVD events and associated changes in quality of life.Although medications are often used as the first-line strategy to stabilize or favorably modify traditional CVD risk factors, lifestyle changes are also associated with impressive mortality reductions, the magnitude of which are similar to or greater than those observed with cardioprotective medications. 6 Moreover, the effects of lifestyle change and drug therapy on CVD risk reduction appear to be independent and additive. 7