Will the next spillover pandemic be deadlier than the COVID-19?: A wake-up call

Choudhary, Om Prakash; Choudhary, Priyanka; Ali, Rezhna Kheder; Maulud, Sazan Qadir; Dhawan, Manish; Mohammed, Teroj A.

doi:10.1016/j.ijsu.2021.106208

Cited by 20 publications

(20 citation statements)

References 12 publications

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“…Finally, an urgent ceasefire is a priority, as the ongoing war will have a negative impact globally, among them worsening the situation in the ongoing pandemic from the epidemiological and economical point of view. Furthermore, the COVID-19 pandemic has not been over yet, and ramping up vaccination in humans as well as animals [ 6 , 7 ] is urgent, besides keeping an eye on other possible public health threats such as the NeoCoV and Detlacron as well.…”

mentioning

confidence: 99%

Russo-Ukrainian war: An unexpected event during the COVID-19 pandemic

Choudhary

Saied

Choudhary

et al. 2022

Travel Medicine and Infectious Disease

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mentioning

confidence: 99%

Russo-Ukrainian war: An unexpected event during the COVID-19 pandemic

Choudhary

Saied

Choudhary

et al. 2022

Travel Medicine and Infectious Disease

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“…In conclusion, several studies are required to understand this novel coronavirus and its immunology including the vaccines, if it exists in humans as it has only been reported in the animals so far. Furthermore, the COVID-19 pandemic has not been over yet, and there is an urgent need to ramp up vaccination in humans as well as animals [ 8 ], besides keeping an eye on other possible public health threats such as the NeoCoV as well.…”

mentioning

confidence: 99%

NeoCoV: A foresight of the next possible pandemic

Dhawan

Thakur

Choudhary

et al. 2022

International Journal of Surgery

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“…Perhaps a range of attenuating mutations may be identified in different viral taxa to facilitate the rapid development of LAVs through reverse genetics. Nevertheless, if another pandemic coronavirus emerges [ 187 , 188 , 189 ], many mutations identified in this review may still be applicable.…”

Section: Discussionmentioning

confidence: 99%

The Reassessed Potential of SARS-CoV-2 Attenuation for COVID-19 Vaccine Development—A Systematic Review

Goławski

Lewandowski

Jabłońska

et al. 2022

Viruses

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Live-attenuated SARS-CoV-2 vaccines received relatively little attention during the COVID-19 pandemic. Despite this, several methods of obtaining attenuated coronaviruses are known. In this systematic review, the strategies of coronavirus attenuation, which may potentially be applied to SARS-CoV-2, were identified. PubMed, Scopus, Web of Science and Embase databases were searched to identify relevant articles describing attenuating mutations tested in vivo. In case of coronaviruses other than SARS-CoV-2, sequence alignment was used to exclude attenuating mutations that cannot be applied to SARS-CoV-2. Potential immunogenicity, safety and efficacy of the attenuated SARS-CoV-2 vaccine were discussed based on animal studies data. A total of 27 attenuation strategies, used to create 101 different coronaviruses, have been described in 56 eligible articles. The disruption of the furin cleavage site in the SARS-CoV-2 spike protein was identified as the most promising strategy. The replacement of core sequences of transcriptional regulatory signals, which prevents recombination with wild-type viruses, also appears particularly advantageous. Other important attenuating mutations encompassed mostly the prevention of evasion of innate immunity. Sufficiently attenuated coronaviruses typically caused no meaningful disease in susceptible animals and protected them from challenges with virulent virus. This indicates that attenuated COVID-19 vaccines may be considered as a potential strategy to fight the threat posed by SARS-CoV-2.

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Will the next spillover pandemic be deadlier than the COVID-19?: A wake-up call

Cited by 20 publications

References 12 publications

Russo-Ukrainian war: An unexpected event during the COVID-19 pandemic

Russo-Ukrainian war: An unexpected event during the COVID-19 pandemic

NeoCoV: A foresight of the next possible pandemic

The Reassessed Potential of SARS-CoV-2 Attenuation for COVID-19 Vaccine Development—A Systematic Review

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