Will We Have a Cohort of Healthcare Workers Full Vaccinated against Measles, Mumps, and Rubella?

Trevisan, Andrea; Bertoncello, Chiara; Artuso, Elisa; Frasson, Clara; Lago, Laura Pérez; Nuzzo, Davide De; Nicolli, Annamaria; Maso, Stefano

doi:10.3390/vaccines8010104

Cited by 7 publications

(8 citation statements)

References 28 publications

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“…Finally, the phenomenon of vaccine hesitancy is the cause of low vaccination coverage even among HCWs [36,37]. As previously reported [14], this phenomenon will certainly be much less evident in the near future given that our series shows a high vaccination coverage in what will be future HCWs.…”

Section: Discussionmentioning

confidence: 53%

“…The first evidence is not easily understood. A possible explanation has been recently suggested on a "negative" influence of the Rubini strain in MMR combination used for mumps between 1990 and 1995 [14], but at the moment, it remains unresolved. Nevertheless, the recent WHO position paper on measles vaccine [20] claims that "although vaccine-induced antibody concentrations decline over time and may become undetectable, immunological memory persists and, following exposure to measles virus, most people who have been vaccinated produce a protective immune response".…”

Section: Discussionmentioning

confidence: 99%

“…Linear regression coefficient r (Pearson product-moment correlation coefficient) was used (if appropriate) to relate single independent variables with antibody titer. Furthermore, four years of birth groups were assumed as previously [14]: born in 1980-1985, 1986-1990, 1991-1995, and after 1995. Other statistical analyses are descriptive. Significance is stated by p < 0.05.…”

Section: Statisticsmentioning

confidence: 99%

“…Our previous research [11][12][13][14] provided evidence that medical school students were not completely protected, at least as regards the rate of circulating antibodies.…”

Section: Introductionmentioning

confidence: 97%

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Vaccination and Immunity toward Measles: A Serosurvey in Future Healthcare Workers

et al. 2021

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Measles is a very contagious infectious disease, and vaccination is the only medical aid to counter the spread of the infection. The aim of this study was to evaluate the influence of vaccination schedule and type of vaccine, number of doses, and sex on the immune response. In a population of Italian medical students (8497 individuals born after 1980 with certificate of vaccination and quantitative measurement of antibodies against measles), the prevalence of positive antibodies to measles and antibody titer was measured. Vaccination schedule such as number of doses and vaccine type (measles alone or combined as measles, mumps and rubella (MMR)) and sex were the variables considered to influence the immune response. The vaccination schedule depends on the year of birth: students born before 1990 were prevalently vaccinated once and with measles vaccine alone (not as MMR). One dose of vaccine induces a significantly (p < 0.0001) higher positive response and antibody titer than two doses, in particular when measles alone is used (p < 0.0001). Females have a significantly higher percentage of positive response (p = 0.0001) than males but only when the MMR formulation was used. Multiple linear regression confirms that sex significantly influences antibody titer when only MMR is used, after one (p = 0.0002) or two (p = 0.0060) doses. In conclusion, vaccination schedule and, partially, sex influence immune response to measles vaccination. Most notably, the measles vaccine alone (one dose) is more effective than one and two doses of MMR.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Statisticsmentioning

confidence: 99%

“…Our previous research [11][12][13][14] provided evidence that medical school students were not completely protected, at least as regards the rate of circulating antibodies.…”

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Vaccination and Immunity toward Measles: A Serosurvey in Future Healthcare Workers

et al. 2021

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“…The students were further divided into five year of birth groups (born before 1980, between 1980 and 1985, between 1986 and 1990, between 1991 and 1995, and after 1995) to better highlight the differences in vaccination compliance as previously described [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

Response to Vaccination against Mumps in Medical Students: Two Doses Are Needed

Trevisan

Moretto

Bertoncello

et al. 2021

Viruses

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Mumps is a vaccine-preventable infectious disease diffuse worldwide. The implementation of mumps vaccination reduced largely the spread of infection. On 11,327 Medical School students the prevalence of mumps positive antibodies was evaluated according to dose/doses of vaccine, year of birth and sex. Compliance to mumps vaccine was low in students born before 1990 but increased consistently after this year, above all compliance to two doses, due to the implementation of the vaccine offer. Positivity of mumps antibodies is significantly (p < 0.0001) lower in students vaccinated once (71.2%) compared to those vaccinated twice (85.4%). In addition, students born after 1995, largely vaccinated twice, showed a seropositivity near to 90%. Further, females had a significantly (p < 0.0001) higher proportion of positive antibodies after vaccination than males, both one (74.6% vs. 64.7%) and two doses (86.8% vs. 82.9%). Finally, seropositivity after two vaccine doses remains high (86.1%) even 15 years after the second dose. In conclusion, the research highlighted that vaccination against mumps reaches a good level of coverage only after two doses of vaccine persisting at high levels over 15 years and induces a more significant response in females.

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Varicella seroepidemiology and immunization in a cohort of future healthcare workers in the pre-vaccination era

Trevisan

Nicolli

Nuzzo

et al. 2020

International Journal of Infectious Diseases

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The goal of this study was to establish the seroprevalence of positive antibodies against varicella and compliance with varicella vaccination in the pre-vaccination era. Methods: A cohort of 10 683 Italian students from Padua University Medical School (from 2004 to 2019) were enrolled and classified as unvaccinated, vaccinated once, or vaccinated twice against varicella, according to their vaccination certificate. The antibody titre was measured and the seroprevalence of positive subjects was determined. Subjects with negative or equivocal antibodies were invited for vaccination, and then the antibody titre was retested. Results: Unvaccinated students were mostly seropositive (95.6%), compared with vaccinated students who were less seropositive (68.0% after one dose and 78.6% after two doses) and had significantly lower antibody titres (p < 0.0001). The post-test vaccination had a positive response rate of 85.4%: 67.4% after one dose and 91.4% after two doses. Conclusions: In the pre-vaccination era, only 3.3% of future healthcare workers were vaccinated against varicella (1.1% once and 2.2% twice). Vaccination or revaccination of negative and equivocal individuals could reduce the number of susceptible people. Implementation of varicella vaccine (two doses) in healthcare workers is of primary importance to reduce the risk of transmission.

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Will We Have a Cohort of Healthcare Workers Full Vaccinated against Measles, Mumps, and Rubella?

Cited by 7 publications

References 28 publications

Vaccination and Immunity toward Measles: A Serosurvey in Future Healthcare Workers

Vaccination and Immunity toward Measles: A Serosurvey in Future Healthcare Workers

Response to Vaccination against Mumps in Medical Students: Two Doses Are Needed

Varicella seroepidemiology and immunization in a cohort of future healthcare workers in the pre-vaccination era

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