Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation

Pretzel, Shannon; Kuhn, Katherine; Pal, Lubna; Polotsky, Alex J.; Taylor, Hugh S.; Zhang, Heping; Robins, Jared C.; Young, Steven L.; Santoro, Nanette

doi:10.1007/s43032-021-00705-0

Cited by 3 publications

(6 citation statements)

References 19 publications

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“…10,11 However, feasibility surveys for a placebo-controlled endometriosis trial in the United States indicate a surprisingly high (90%) agreement to participate. 12 These disparate findings may reflect the daily impacts of the condition being treated, and the perceived effectiveness of treatment, but may also be influenced by cultural differences between the countries.…”

Section: Discussionmentioning

confidence: 99%

Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation

Anderson

Blaxall

Lensen

et al. 2022

Aust NZ J Obst Gynaeco

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Background Add‐ons at the time of in vitro fertilisation (IVF) have become commonplace, despite a general lack of evidence that they are effective and safe. The ‘Colorado Protocol’ is a commonly used add‐on consisting of aspirin, steroid and an antibiotic. Before commencing planning for a clinical trial evaluating the Colorado Protocol, researchers and funders need evidence that the Colorado Protocol is being prescribed, and to be assured that sufficient numbers of participants can be recruited for a clinical trial. Aims To survey fertility clinicians and patients on attitudes toward use of add‐ons during IVF, willingness of patients to be randomly assigned to an add‐on trial treatment or placebo, and what would be the clinically meaningful outcomes, using the Colorado Protocol as a test case. Materials and methods Two online surveys were conducted: clinicians from fertility clinics across the United Kingdom, Australia, and New Zealand; and patients from Auckland‐based clinics and NZ patient support groups. Results Of 58 clinicians, 44 (75%) had recommended an add‐on within the preceding year. Thirty‐nine (67%) clinicians were aware of the Colorado Protocol, with 17 (29%) having recommended it within the preceding year. Of the 289 patients, 80% indicated willingness to take trial medications during IVF, and 68% were willing to be randomly assigned to the placebo arm of a trial. The median perceived minimum clinically important difference in live births in both samples was 5%. Conclusions A future trial of this add‐on in IVF would be supported by patients in the context of the New Zealand fertility healthcare system.

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Section: Discussionmentioning

confidence: 99%

Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation

Anderson

Blaxall

Lensen

et al. 2022

Aust NZ J Obst Gynaeco

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“…연구 수행 지역을 살펴보면 유럽에서 3편[이탈리아 (Cirillo et al, 2021), 폴란드 (Ilska et al, 2021), 세르비아 (Mitrović et al, 2021)], 중동에서 2편[이스라엘 (Aizer et al, 2022;Avraham (Cao et al, 2021), 대만 (Lin et al, 2021)]의 논문이 발간되었으며 미 국 및 캐나다 5편[미국 (Lawson et al, 2021;Pretzel et al, 2022;Seifer et al, 2021;Vaughan et al, 2020), 캐나다 (Vastis et al, 2022)]에서 최다 논문을 발표하였고, 브라질에서 발표한 논문 이 1편 (Braga et al, 2020)이었다. (Cheng et al, 2018;Freeman et al, 2018;Jung & Kim, 2017;Massarotti et al, 2019;Nicoloro-SantaBarbara et al, 2018).…”

Section: 최종 13편의 문헌에 대한 일반적 특성은unclassified

“…이 연구에서는 PRISMA-ScR의 스코핑 리뷰 방 법을 참고하여 연구 결과를 분석 후 합의된 결론을 도출하였으 며, 고찰된 결과를 요약한 표 및 그림으로 제시하였다 (Tricco et al, 2018). (Braga et al, 2020;Vaughan et al, 2020), 2021년 7편 (Cao et al, 2021;Cirillo et al, 2021;Ilska et al, 2021;Lawson et al, 2021;Lin et al, 2021;Mitrović et al, 2021;Seifer et al, 2021), 2022년 4편 (Aizer et al, 2022;Avraham et al, 2022;Pretzel et al, 2022;Vastis et al, 2022)이었고 모두 국외 저널에 발표된 연구였다.…”

unclassified

“…https://doi.org/10.21896/jksmch.2023.27.2.80 발표된 연구의 저널을 학술분야에 따라 분류하면 생식의학 (reproductive medicine, fertility & sterility)분야에서 10편(Aizer et al, 2022;Avraham et al, 2022;Braga et al, 2020;Cirillo et al, 2021;Ilska et al, 2021;Lawson et al, 2021;Pretzel et al, 2022;Seifer et al, 2021;Vastis et al, 2022;Vaughan et al, 2020)으로 가장 많고, 정신의학 및 심리학(psychiatry, psychology)분야에서 2편(Cao et al, 2021;Mitrović et al, 2021), 보완의학(COMPLEMENTAry medicine)분야는 1편(Lin et al., 2021)이었다.2.스 정도가 달라진다는 연구도 포함되었다(Seifer et al, 2021). 둘째, 코로나 팬데믹 시기의 난임 치료 참여자의 대한 임신 성공 률 변화에 관한 연구이다.…”

unclassified

“…둘째, 코로나 팬데믹 시기의 난임 치료 참여자의 대한 임신 성공 률 변화에 관한 연구이다. 임신 성공률 여부에 대한 연구는 총 3 편(Aizer et al, 2022;Avraham et al, 2022;Vastis et al, 2022) 신 계획 변화(Braga et al, 2020), 치료인식(Pretzel et al, 2022) 및 의료이용의 변화(Lin et al, 2021)로 구성되었다. 연구 자료원을 살펴보면, 코로나 팬데믹으로 인한 스트레스,…”

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A Scoping Review of the Effect of the COVID-19 Pandemic on Patients Under Infertility Treatment

Jeon¹,

Kim²,

Jeong³

2023

J Korean Soc Matern Child Health

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Purpose: This study aimed to conduct a scoping review to understand how the coronavirus disease 2019 (COVID-19) pandemic has affected patients under infertility treatment.Methods: The 5 steps of the scoping review by Arksey and O’Malley were applied: (1) identifying the research question; (2) identifying relevant studies; (3) study selection; (4) charting the data; and (5) collating, summarizing, and reporting the results. Using 2 databases (PubMed and Cochrane Library), studies on COVID-19 and infertility treatment were searched, and 13 articles were selected for analysis.Results: The studies were conducted in North America (5 articles), Europe (3 articles), Asia (2 articles), and other regions (3 articles). The academic fields of the published journals were primarily reproductive medicine (10 articles), followed by psychiatry and psychology (2 articles), and complementary medicine (1 article). Regarding the research topic, studies on stress and anxiety were the most common (7 articles), followed by pregnancy rates (3 articles), and pregnancy planning or treatment decisions (3 articles). The COVID-19 pandemic had a negative effect on stress and anxiety of patients in 5 out of 7 articles, no changes in pregnancy rates in 3 out of 3 articles, and negative effects on pregnancy planning or treatment decisions in 2 out of 3 articles.Conclusion: The results of this review suggest that evidence-based information on patients with infertility is needed to prevent unnecessary anxiety, stress, and treatment delays in the upcoming postpandemic transition period.

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Endometriosis and COVID-19: A Systematic Review and Meta-Analysis

Kabani

Ramos-Niño

Ramdass

2022

IJMS

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Endometriosis is defined as ectopic endometrial tissues dispersed outside the endometrium. This can cause disruption in hormonal and immunological processes, which may increase susceptibility to SARS-CoV-2 infection. Worsening of endometriosis symptoms may occur as a result of this infection. The aim of our review was to estimate the pooled prevalence of SARS-CoV-2 infection and the health impacts of the COVID-19 pandemic in endometriosis patients. We conducted a systematic review and meta-analysis. MEDLINE, Science Direct, Scopus, and Google Scholar databases were searched, using the keywords: (endometriosis) AND (COVID-19 OR SARS-CoV-2). Forest plots and pooled estimates were created using the Open Meta Analyst software. After screening 474 articles, 19 studies met the eligibility criteria for the systematic review, and 15 studies were included in the meta-analyses. A total of 17,799 patients were analyzed. The pooled prevalence of SARS-CoV-2 infection in endometriosis patients was 7.5%. Pooled estimates for the health impacts were 47.2% for decreased access to medical care, 49.3% increase in dysmenorrhea, 75% increase in anxiety, 59.4% increase in depression, and 68.9% increase in fatigue. Endometriosis patients were undeniably impacted by the COVID-19 pandemic, which caused the worsening of symptoms such as dysmenorrhea, pelvic pain, anxiety, depression, and fatigue.

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Willingness of Women with Endometriosis Planning to Undergo IVF to Participate in a Randomized Clinical Trial and the Effects of the COVID-19 Pandemic on Potential Participation

Cited by 3 publications

References 19 publications

Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation

Surveys of clinician and patient attitudes to an add‐on for in vitro fertilisation

A Scoping Review of the Effect of the COVID-19 Pandemic on Patients Under Infertility Treatment

Endometriosis and COVID-19: A Systematic Review and Meta-Analysis

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