PurposeThe onset of the coronavirus disease 2019 (COVID-19) has led to loss of lives and jobs and other adverse effects on persons, families and businesses. With its frightening tendencies, it was a sigh of relief with the discovery of vaccines to mitigate its disastrous effects. However, participation in the vaccination exercise in Ghana has been slow and unencoraging. This paper sought to identify the factors that influence the perception and willingness of individuals to receive the COVID-19 vaccine.Design/methodology/approachFor this study, structured questionnaires were administered to 1,350 respondents selected at random by way of purposive sampling from specific regions that were also randomly selected. Out of this sample, a total of 1,296 were found to be in useable form. The probit model estimation with marginal effects was used to determine both perception and willingness to take the COVID-19 vaccine.FindingsThe authors observed that increases in age and manufacturing sector workers were positively associated with vaccine perception, while both males and females residing in the Bono and Central regions had negative perceptions toward the vaccine. Among male workers, education and living in Accra had a negative relationship with vaccine perception, while for female workers, education had a positive influence on vaccine perception. Additionally, workers in the transport sector and those residing in urban areas were more inclined to receive the COVID-19 vaccine in Ghana, regardless of gender. Again, the authors observed that larger household size, people with no formal education and females with primary education were more willing. Also, increase in age for males reduced willingness, while residents in the greater Accra region were less willing to take the vaccine.Originality/valueTo the best of the authors' belief and knowledge, the observations and recommendations made are consistent with theory and empirical studies and contribute immensely to the discussions about the most effective ways of combating the COVID-19 pandemic. It also offers a nuanced perspective on how policy-makers can enact policies that ensure efficient and effective ways of dealing with future epidemics.