Willingness to Participate and Enroll in a Phase 3 Preventive HIV-1 Vaccine Trial

O'connell, Jacqueline M.; Hogg, Robert S.; Chan, Keith; Strathdee, Steffanie A.; McLean, Nancy; Martindale, Steve; Willoughby, Brian J.; Remis, Robert S.

doi:10.1097/00126334-200212150-00010

Cited by 47 publications

(38 citation statements)

References 20 publications

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“…Several studies of WTP indicated that perceived vulnerability to HIV/STD infection was associated with greater WTP in either HIV vaccine trial or HIV test (Bartholomeyczik et al, 1989;O'Connell et al, 2002). By contrast, the study among the Hong Kong cross-border sexnetworking population (Lau & Wong, 2001) and the present study did not find a significant correlation between perceived vulnerability and WTP.…”

Section: Discussioncontrasting

confidence: 96%

Willingness to Participate in HIV/STD Prevention Activities among Chinese Rural-To-Urban Migrants

Yang

Li²,

Stanton³

et al. 2004

AIDS Education and Prevention

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Data from 4,208 migrants aged 18-30 years old in Beijing and Nanjing, China, were analyzed to examine the correlates of willingness to participate (WTP) in HIV/STD prevention intervention activities among Chinese rural-to-urban migrants. Overall, 83.3% of the respondents would be willing to participate. Increased WTP was associated with employment in the industrial sector (OR = 1.59, 95% CI: 1.11-2.29), migrating to cities to learn more about the outside world (OR = 1.31, 95% CI: 1.08-1.59), prior experience with health maintenance (OR = 1.36, 95% CI: 1.11-1.66), higher level of HIV/AIDS awareness (OR = 1.16, 95% CI: 1.02-1.31), and perceived severity of risk behaviors (OR = 1.32, 95% CI: 1.04-1.68). Decreased WTP was associated with increased involvement in health risk behaviors (OR = 0.50, 95% CI: 0.35-0.73), increased perceptions of peer risk involvement (OR = 0.81, 95% CI: 0.68-0.98), perceived intrinsic rewards for risk behaviors (OR = 0.81, 95% CI: 0.68-0.96) and perceptions of HIV-related stigma (OR = 0.68, 95% CI: 0.53-0.89). The high level of WTP suggests that HIV/STD prevention activities are acceptable among rural-tourban migrants. Their awareness of HIV/AIDS should be increased and HIV-related stigma should be reduced to increase the level of WTP. Recruitment and retention of individuals with high-risk behavior in prevention activities will be critical and challenging.Population mobility has been identified as a major risk factor for HIV/STD infection and transmission in many developing countries, including China (Bloom, Urassa, Isingo, Ng'weshemi & Boerma, 2002;Hope, 2000;Zhang & Ma, 2002 For any successful intervention, a prerequisite is that adequate numbers of individuals are willing to participate in it. Estimates of willingness to participate (WTP) will help researchers to determine the feasibility of prevention intervention program. Identification of associated factors may help to develop effective strategies to address those factors in the design and planning to increase WTP and, consequently, to improve participation rates.The issue of WTP in HIV-related programs was first addressed among intravenous drug users (IDUs) in the United States in the late 1980s (Magura et al., 1989;Marlink et al., 1987). During the past 2 decades, a growing number of studies addressing this issue have been reported among diverse populations, including men who have sex with men (MSM), bisexual men, pregnant women, and STD patients. Level of willingness and possible correlates (e.g., demographic characteristics, HIV/AIDS knowledge, health behaviors, and self-perceived susceptibility) have been examined in these studies. A broad range of willingness levels was reported among these varied populations. For example, among IDUs in methadone clinics, one study reported a WTP rate of 85% (39/46) for voluntary HIV testing, whereas another study found only a WTP rate of 38% (114/300) (Magura et al., 1989;Marlink et al., 1987). An international survey among pregnant women in 13 cities from nine developing countries r...

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Section: Discussioncontrasting

confidence: 96%

Willingness to Participate in HIV/STD Prevention Activities among Chinese Rural-To-Urban Migrants

Yang

Li²,

Stanton³

et al. 2004

AIDS Education and Prevention

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“…This study finding is consistent with findings from other hypothetical vaccine preparedness studies (Koblin et al, 1998;Nyamathi et al, 2004;O'Connell et al, 2002;Strathdee et al, 2000). In particular, questions were raised about the stigma and discrimination due to post-vaccination seropositivity, as well as issues of confidentiality.…”

supporting

confidence: 93%

Perceptions of a Community Sample about Participation in Future HIV Vaccine Trials in South India

et al. 2006

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Focus group discussions were conducted to assess factors that might impact participation of subgroups in Chennai for future HIV vaccine trials. The participants were 112 men and women representing the following: (1) transport workers; (2) clients who attended a sexually transmitted disease clinic; (3) injection drug users; (4) men having sex with men; (5) women in sex work; and (6) monogamous married women. Participants expressed an intense interest in future HIV vaccine trials. Willingness to participate in future trials included altruism and the desire to have a protective vaccine for the future. Assurances regarding stigma and confidentiality, and compensation for families in the event of a poor outcome with a future HIV vaccine trial were reported. Concerns also centered on the impact of seroconverting, and a possible increase in risk behaviors. The need for education and counseling about the dangers of engaging in risky behavior during and after participating in a future HIV vaccine trial is discussed.

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“…Finally, trial participants may not be representative of other MSM, and caution should be used in generalizing our results. Indeed, if highrisk MSM tend to enrol in vaccine trials, 1,9,10 regression to the mean could explain reductions in sexual risk behaviours that might be reported from vaccine trials lacking a comparison group that receives neither vaccine nor placebo.…”

Section: Discussionmentioning

confidence: 99%

Sexual risk behaviour of Canadian participants in the first efficacy trial of a preventive HIV-1 vaccine

Lampinen¹

2005

Canadian Medical Association Journal

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Willingness to Participate and Enroll in a Phase 3 Preventive HIV-1 Vaccine Trial

Abstract: Improving community and participant knowledge about preventive HIV vaccine trials may help ensure informed consent. However, whether informing potential participants will reverse or contribute to the declining trend in WTP observed in this cohort warrants further investigation.

Cited by 47 publications

References 20 publications

Willingness to Participate in HIV/STD Prevention Activities among Chinese Rural-To-Urban Migrants

Willingness to Participate in HIV/STD Prevention Activities among Chinese Rural-To-Urban Migrants

Perceptions of a Community Sample about Participation in Future HIV Vaccine Trials in South India

Sexual risk behaviour of Canadian participants in the first efficacy trial of a preventive HIV-1 vaccine

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