Willingness to participate in health research: Tunisian survey

Abstract

BackgroundFew studies have identified the willingness rate of developing countries population to be enrolled in clinical trials.MethodsAll participants including patients (n = 612), healthy volunteers (n = 354) and doctors (n = 134) completed a questionnaire to examine factors affecting the consent to participate in medical research.ResultsOverall, 80 % of the included population agree to participate in health research. This rate was lower for trials dealing with life-threatening diseases (38 %). Altruism and perceived risk of harm were the main reason to respectively accept or refuse to participate in clinical trials. Factors significantly associated with willingness were: age <40 years (Odds Ratio (OR) 1.6 [95 % Confidence Interval (CI) 1.2-2.1]) and prior history of blood donation (OR 2.4 [95 % CI 1.7-3.5]).ConclusionMost participants expressed their willingness to be included in medical research especially if they are young or if they have history of blood donation. However, consent to participate is low when medical research required acute care.Electronic supplementary materialThe online version of this article (doi:10.1186/s12910-016-0131-3) contains supplementary material, which is available to authorized users.

A Survey on the Willingness of Clinical Research Professionals to Participate in Clinical Research

“…Around 90% of Fayed's [3] sample responded that they were willing to participate in clinical trials. These results were similar to those of Bouida et al [4], in which 89% of physicians responded that they were willing to participate in clinical trials. Apart from the level of willingness of professionals to participate in clinical trials, the level of education and knowledge is another factor that distinguishes the public from professionals.…”

“…Categorical data were presented as percentages and data relating to willingness, safety perceptions, and agreement with statements were collected using a Likert scale (1)(2)(3)(4)(5). The Likert-scale data were presented as median values and quantiles and were compared between subgroups of participants using non-parametric tests (Mann Whitney and Kruskal Wallis tests as appropriate).…”

The willingness to participate in biomedical research involving human beings in low‐ and middle‐income countries: a systematic review

“…Additional reasons for participation mentioned were: ability to withdraw , advice from physician , community involvement , cultural acceptability , creating a feeling of community , low pressure decision , need for treatment , research involving a non‐invasive procedure , peer enrolment , low perception of risk , result availability , guarantee of confidentiality , being unaware of voluntariness of participation , research outcome, and finally seeing research participation as motivation to avoid risky behaviour .…”

Paying patient and caregiver research participants: putting theory into practice

“…, Bouida et al . ). A lack of understanding about the research aims and methodology and concerns about the study length, are other influencing factors (Geppert et al .…”