Willingness to Pay and Time Trade-off in Thai Patients with Port-Wine Stains

Jantarakolica, Tatre; Wanitphakdeedecha, Rungsima; Yan, Chadakan; Yogya, Yuri; Sirisuthivoranunt, Surachet; Wongdama, Supisara; Phumariyapong, Phumithep; Sudhipongpracha, Tatchalerm

doi:10.2147/ceor.s382735

Cited by 2 publications

(1 citation statement)

References 30 publications

(55 reference statements)

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“…We discovered that young children were either unconcerned or less concerned about PWS than adolescents and adults. Patients older than 5 years were more likely to pay attention and spend more time than patients ≤ 5 years [ 22 ]. QoL is multidimensional and subjective, comprising physical, mental, and social elements of well-being [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

Dermatology Life Quality Index in Thai Patients with Facial Port-Wine Stains

Jantarakolica,

Wanitphakdeedecha,

Yan

et al. 2023

Dermatol Ther (Heidelb)

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Introduction Port-wine stains (PWS) are congenital capillary abnormalities caused by immature, venule-like vasculature that progressively dilates due to poor endothelial cell differentiation. PWS affects between 0.3% and 0.9% of newborns, with 90% of cases occurring on the face. Individuals with facial PWS and their parents had a significant negative impairment on their quality of life (QoL) and also suffered from psychological disabilities. Methods This was a cross-sectional questionnaire-based survey study in Thailand from July 2021 to April 2022. The questionnaires included demographic data, subjective evaluation (SE), and the Dermatology Life Quality Index (DLQI). The questionnaire was performed with a full scale and adjusted scale of validity and reliability test of DLQI using factor analysis and Cronbach’s alpha. The study outcome was a subjective evaluation and DLQI in patients who received pulsed dye laser (PDL) treatment. Results Of the 54 patients, 35.2% (19) are male, and 64.8% (35) are female. Regarding age groups, 64.8% (35) are below 5 years old, and 35.2% (19) are older than 5 years. SE results showed that males evaluated an improvement of the facial PWS lesion significantly better than females ( P < 0.05). The older age group graded the percentage of improvement better than the younger age group ( P < 0.01). The result of the DLQI showed no difference in DLQI between gender. Older age result resulted in a significantly different DLQI compared with younger age ( P < 0.01). Parent-reported DLQI improvement was less than self-reported DLQI improvement in patients with PWS treated with PDL ( P < 0.05). Concerning the instrument of the study, the validity and reliability analysis of the DLQI questionnaire using factor analysis and Cronbach’s alpha have been performed. The adjusted scale with the 5-item DLQI questionnaire is more appropriate in terms validity and reliability. Conclusion This study demonstrates that facial PWS reduces the QoL as measured by DLQI. We discovered that the QoL of patients and parents with PWS was significantly impaired. The main influencing factors were older age, the improved perception between gender, and PDL treatments. In addition, we found only five questions that are reliable for PWS. The adjusted five-item DLQI questionnaires are more appropriate regarding validity and reliability. Trial Registration Number TCTR20230210001, COA no. si 1059/2020.

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Section: Discussionmentioning

confidence: 99%

Dermatology Life Quality Index in Thai Patients with Facial Port-Wine Stains

Jantarakolica,

Wanitphakdeedecha,

Yan

et al. 2023

Dermatol Ther (Heidelb)

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Comparing EQ-5D-5L, PROPr, SF-6D and TTO utilities in patients with chronic skin diseases

Szabó,

Brodszky,

Rencz

2024

Eur J Health Econ

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Objectives We aim to compare the measurement properties of three indirect (EQ-5D-5L, PROPr, SF-6D) and one direct (time trade-off, TTO) utility assessment methods in patients with chronic skin diseases. Methods 120 patients with physician-diagnosed chronic skin diseases (psoriasis 39%, atopic dermatitis 27%, acne 19%) completed a cross-sectional survey. Respondents completed the EQ-5D-5L, PROMIS-29+2 and SF-36v1 questionnaires and a 10-year TTO task for own current health. Utilities were computed using the US value sets. Ceiling, convergent and known-group validity were compared across the utilities derived with these four methods. Known-groups were defined based on general, physical and mental health. The agreement between utilities was assessed using intraclass correlation coefficients (ICC). Results Mean utilities for the EQ-5D-5L, PROPr, SF-6D and TTO were 0.79, 0.47, 0.76 and 0.89. In corresponding order, the ceiling was 28%, 0%, 2% and 65%. The SF-6D showed excellent agreement with the EQ-5D-5L (ICC = 0.770). PROPr demonstrated poor agreement with the EQ-5D-5L (ICC = 0.381) and fair with SF-6D utilities (ICC = 0.445). TTO utilities showed poor agreement with indirectly assessed utilities (ICC = 0.058–0.242). The EQ-5D-5L better discriminated between known groups of general and physical health, while the SF-6D and PROPr outperformed the EQ-5D-5L for mental health problems. Conclusion There is a great variability in utilities across the four methods in patients with chronic skin conditions. The EQ-5D-5L, despite its higher ceiling, appears to be the most efficient in discriminating between patient groups for physical health aspects. Our findings inform the choice of instrument for quality-adjusted life year calculations in cost-utility analyses.

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Willingness to Pay and Time Trade-off in Thai Patients with Port-Wine Stains

Cited by 2 publications

References 30 publications

Dermatology Life Quality Index in Thai Patients with Facial Port-Wine Stains

Dermatology Life Quality Index in Thai Patients with Facial Port-Wine Stains

Comparing EQ-5D-5L, PROPr, SF-6D and TTO utilities in patients with chronic skin diseases

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