Wilms' tumor arising in a multicystic kidney

Oddone, M.; Marino, C; Sergi, Consolato; Occhi, M; Negri, Francesco; Kotitza, Z.; Bernardi, Bruno; Jasonni, Vincenzo; Tomà, Paolo

doi:10.1007/bf02015442

Cited by 29 publications

(5 citation statements)

References 8 publications

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“…There were reports on the association of WT with MCDK, primarily based on case studies and small series (Table 1 [21–28]). Evidence supporting these case reports is often incomplete and not supported by outside pathological review [3].…”

Section: Resultsmentioning

confidence: 99%

Non‐surgical management of multicystic dysplastic kidney

2008

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OBJECTIVES To better define the outcome and association of multicystic dysplastic kidney (MCDK) with hypertension, vesico‐ureteric reflux (VUR), infection and cancer, as there is no consensus on the management of patients born with MCDK. The risk of cancer has dictated the surgical management of the disease in the past. METHODS The Medline database was searched for articles published between 1965 and 2006 and written in the English language, and containing the keywords ‘multicystic dysplastic kidney’. RESULTS The inclusion criteria were met by 105 reports that were subsequently analysed. Of MCDK, 60% regress or involute within 3 years. About 25% of patients will have VUR into the contralateral kidney, of which 90% is grade ≤3. The risk of urinary tract infection appears to be associated with VUR or coexistent abnormalities rather than the MCDK. The risk of hypertension is no greater than that in the general population and nephrectomy is usually not curative. The overall risk of Wilms’ tumour developing in a MCDK is <1 in 2000. All reported Wilms’ tumours were identified before 4 years of age and 70% presented as a palpable mass. CONCLUSIONS Published reports support the non‐surgical management of MCDK. Common practice has been to remove palpable or growing MCDKs, although these represent a very small fraction of MCDKs. In theory, ultrasonographic surveillance until 4 years old might allow the earlier detection of a Wilms’ tumour, and decrease the intensity of chemotherapy and improve prognosis. Previous reports do not prove or disprove this concept, and the appropriate frequency of surveillance is not evident.

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Section: Resultsmentioning

confidence: 99%

Non‐surgical management of multicystic dysplastic kidney

2008

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“…Pediatric renal tumors are rare, but not an insignificant portion of pediatric neoplasms being strongly associated with abnormal blastogenetic processes. 3,46 It has been suggested that the risk of developing Wilms' tumor increases with childhood insecticide exposures. 16 In addition, parental pesticide/herbicide exposures before birth (pre-partum) increase the risk of developing Wilms' tumors.…”

Section: Discussionmentioning

confidence: 99%

Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary

2022

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Background There are hereditary types of nephroblastoma or Wilms’ tumor associated with exposure of the germ cells of either parent to harmful environmental factors. Some studies have examined the exposure of compounds used pesticides and herbicides as a risk factor for Wilms’ tumor. Methods A systematic review and meta-analysis were carried out on case-control studies to establish the potential link between exposure to these organic molecules and Wilms’ tumor occurrence in children rigorously. We examined the monographs on some organo-phosphate insecticides and herbicides issued by the International Association for the Research on Cancer (IARC) under the auspices of the World Health Organization (WHO). PUBMED, SCOPUS, and Google Scholar studies (1960–2021) were identified and systematically reviewed following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Subgroup analyses were conducted after stratification for occupational versus residential exposure and before birth (prenatal) vs. after birth (postnatal) exposure. In addition, we revised the monographs on chemical compounds issued recently by the IARC/WHO. Results Our findings seem to consolidate that parental pesticide exposure during the preconception or pregnancy period is correlated with an increased occurrence risk for Wilms’ tumor. We confirm the validity of the WHO essays on certain organophosphate herbicides and insecticides, which support these compounds, may be highly relevant in future cancer prevention policies. Conclusion Parental exposure to pesticides, particularly in household settings, is poorly emphasized in our society. There is a strong association between these organophosphate compounds and pediatric cancer. Public health agencies may need to take stronger action than in the past.

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“…There have been some exceptional complications of the MCK such as hypertension (cured after nephrectomy) [1] and malignant degeneration [4,11,12].…”

Section: Discussionmentioning

confidence: 99%