Wilms tumor in childhood: Single centre retrospective study from the National Institute of Oncology of Rabat and literature review

Rais, Fadoua; Benhmidou, Naoual; Rais, Ghizlane; Loughlimi, Hasnaa; Kouhen, Fadila; Maghous, Abdelhak; Aarab, Jihan; Bellahammou, Khadija; Moukinebillah, Mouna; Khattab, M.; Chala, Sanaa; Elmejjaoui, Sanaa; Kebdani, Tayeb; Elkacemi, H.; Benjaafar, Noureddine

doi:10.1016/j.phoj.2016.07.006

Cited by 5 publications

(7 citation statements)

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“…There is a slight female preponderance in the Western data with male: female ratio of 0.92:1 in the unilateral case and 0.6:1 bilateral case; [3] however, our study showed the male preponderance with male: female ratio of 1.09:1. Male preponderance was also seen in the study of Rais et al and Mishra et al, [2,9] while equal gender distribution was seen in the study of Naguib et al, [10] majority of the patients were from rural dwelling due to the fact that most population in this northern belt of Indian subcontinent Kashmir lives in rural area. [11,12] None of our patients had physically obvious genetic abnormality and were likely sporadic.…”

Section: Discussionmentioning

confidence: 69%

“…[13] Clinical representation may reflect the stage at presentation in WT; however, most of the literature has shown the disease presentation at Stage III from Asian continent. [1,2] However Western data suggest earlier presentation of the tumor, [14] where the presentation is mainly Stage I and II. In our study of 23 patients, 11 (47.82%) had upfront biopsies, which lead to the disease upstaging in 21.73% (n = 5/23) WT cases, of which 13.04% (n = 3/23) were upstaged from Stage I and 8.69% (n = 2/23) were upstaged from stage II.…”

Section: Discussionmentioning

confidence: 99%

“…Wilm's tumor (WT) is the most common renal malignancy in children and the fourth most common childhood cancer. [1][2][3] WT is a paradigm for the multimodal treatment of pediatric solid tumors. Improvements in surgical techniques and postoperative care, recognition of the sensitivity of WT to irradiation, and the availability of active chemotherapeutic agents have led to dramatic change in the prognosis for this, once uniformly lethal, malignancy.…”

Section: Introductionmentioning

confidence: 99%

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Wilm's Tumor-Collaborative Approach is needed to Prevent Tumor Upstaging and Radiotherapy Delays: A Single Institutional Study

Wani

Khan

Wani³

et al. 2019

Indian Journal of Medical and Paediatric Oncology

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Context : Successful management of Wilm's tumor (WT) necessitates meticulous attention for proper staging and collaborative effort for its optimal management. Aims : The aim of the study was to observe the patterns of WT. Settings and Design : This study was a single-institutional retrospective study. Subjects and Methods : Twenty-three WT case records were analyzed over 6 years and the data collected were interpreted as number, percent, mean ± and standard deviation with regard to clinicodemographic aspects, staging, and diagnostic modality and treatment options. Results : Mean age was 3.97 ± 2.67 years with maximum number in the 2–5-year age group. Males slightly dominated the number, and majority cases were from the rural area. The major clinical presentation was abdominal mass followed by abdominal pain, fever, vomiting, hematuria, and urinary retention. Left laterality was common and single bilateral WT was seen. Majority of tumors were >10 cm in their largest dimensions. Most WT presented in Stage III followed by Stage I and IV. One was a recurrent tumor. Conclusion : WT was usually diagnosed at the locally advanced or metastatic stages; hence, the comprehensive collaborative approach will help to manage the patients optimally and avoid tumor upstaging and radiotherapy delays. Besides awareness at community level is needed to pick up the disease at the earlier stage to have a better outcome in the form of disease control and disease-free survival.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Wilm's Tumor-Collaborative Approach is needed to Prevent Tumor Upstaging and Radiotherapy Delays: A Single Institutional Study

Wani

Khan

Wani³

et al. 2019

Indian Journal of Medical and Paediatric Oncology

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“…Other studies reported > 50% tumor mass in 82.7% of cases. 18 This Fig. 3 DFS was significantly differing according to risk group (Log rank Mantel-Cox; p < 0.001).…”

Section: Discussionmentioning

confidence: 75%

Profile and Clinical Outcome of Children with Wilms' Tumor treated at a Tertiary Care Centre, India

Singh

Kumar

et al. 2022

South Asian J Cancer

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Background Wilms' tumor (WT) is the most common kidney tumor of the pediatric age group. The outcome of WT has improved due to the evolution of the treatment approach. A prospective observational study was conducted at All India Institute of Medical Sciences (AIIMS), Patna, to analyze the clinical profile along with the response and outcome to neoadjuvant chemotherapy according to the International Society of Pediatric Oncology (SIOP) protocol. Materials and Methods In total, 28 patients of WT visited the radiotherapy department from January 2015 to December 2019. Results Gender distribution showed male preponderance with a median age at diagnosis was 31 months. The abdominal lump was the dominant clinical presentation. The median volume of tumor at diagnosis was 359.48 mL (52.67–1805.76). Radiological staging workup shows that stage I, II, III, IV, and V were 7.1%, 39.3%, 39.3%, 10.7%, and 3.6% respectively. Neoadjuvant chemotherapy (NACT) was received by all patients. Also, 71.4% of patients showed > 50% of tumor volume reduction, while 28.6% of patients showed < 50% of tumor mass reduction. There was a statistically significant decrease in the tumor volume reduction following neoadjuvant chemotherapy (p < 0.001). There was a statistically significant stage down (p = 0.018) of the disease. Bivariate correlation studies showed recurrence was correlating statistically significantly with age < 24 months (p = 0.049), locoregional lymph nodes (p = 0.008), histopathological subtypes (p < 0.001), stage of the disease (p = 0.003), and risk groups (p < 0.001). In addition, 25% of patients developed recurrence during the median follow-up of 25 months. The median disease-free survival (DFS) and overall survival (OS) were not reached. The mean DFS and OS were 48 and 59.13 months, respectively. One- and 3-year DFS were 100% and 64.1%, respectively. One- and 3-year OS were 100% and 75% respectively. Conclusion Our study suggests that most of the patients presented at an advanced stage, thus rendering most of the cases difficult to undergo surgery at presentation. Neoadjuvant chemotherapy followed by surgery may be considered a well-balanced approach with a comparable response and survival outcomes.

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“…This finding was similar to a study from Soyemi SS et al (2013) who reported that 44 patients with WT in Lagos State University Teaching Hospital, Nigeria have the median age of 3 years at diagnosis 23 . Another study conducted by F Rais et al (2016) at Department of Hemato-oncology in Children Hospital of Rabat also stated that WT in children were frequent in male with the ratio of male to female (10:9) 24 .…”

Section: Discussionmentioning

confidence: 92%

The Role of Ultrasonography for Diagnosing Wilms Tumor in Developing Country

Rahmani¹,

Sari²,

Indriasari³

2021

IJHOSCR

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Background: Overall five-year survival rate of Wilm’s Tumor (WT) in developing countries is still poor. Delayed diagnosis is one of the contributing factors, whereas early diagnosis is an important thing for the outcome. It is caused by the WT burden in developing countries that was not comparable with the number of facilities for diagnosis and treatment. Ultrasonography (USG) is the mandatory first-line imaging modality in children with a suspected abdominal mass and an overall sensitivity of 76%. Additionally, it can be found in many health facilities at a lower cost, quick, non-invasive, and carries no risk of radiation. Therefore, the relationship between USG and histopathology should be measured. Materials and Methods: A cross-sectional study with an analytical approach was performed in pediatric (0 untill 18 year of age) renal malignancy and neuroblastoma that admitted to Dr. Hasan Sadikin Hospital, Bandung between 2015-2018. Data were collected from medical records. Statistical analyses using Fisher exact test were done to determine the significance of the relationship between USG and histopathology. Results: Forty-three samples were obtained based on inclusion criteria, such as WT (n=33), neuroblastoma (n=6), renal clear cell carcinoma (n=2) and no specific type of renal malignancy (n=2). Fisher exact test revealed no-significant relationship between USG and histopathology with p-value > 0.05 Conclusion: There is no significant relationship between USG and histopathology. Therefore, centralized unity for USG interpretation is recommended.

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Wilms tumor in childhood: Single centre retrospective study from the National Institute of Oncology of Rabat and literature review

Cited by 5 publications

References 40 publications

Wilm's Tumor-Collaborative Approach is needed to Prevent Tumor Upstaging and Radiotherapy Delays: A Single Institutional Study

Wilm's Tumor-Collaborative Approach is needed to Prevent Tumor Upstaging and Radiotherapy Delays: A Single Institutional Study

Profile and Clinical Outcome of Children with Wilms' Tumor treated at a Tertiary Care Centre, India

The Role of Ultrasonography for Diagnosing Wilms Tumor in Developing Country

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