Wilms’ Tumor in Horseshoe Kidney

Luu, Doan Tien; Duc, Nguyen Minh; My, Thieu-Thi Tra; Bang, Luong Viet; Bang, Mai Tan Lien; Van, Nguyen Dinh

doi:10.1159/000514774

Cited by 6 publications

(6 citation statements)

References 18 publications

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“…Although the current cure rate approaches 85% the early stage of the disease lack specific symptoms, which often delays both diagnosis and optimal treatment (4,5). Moreover, about 25% of Wilms tumor patients will face chronic health problems for many years after diagnosis and treatment (6,7). Therefore, it is of great significance to explore the molecular mechanism of Wilms tumor, such as genes and pathways, to improve its diagnosis, prediction, and treatment.…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis and identification of genes and pathways involved in patients with Wilms tumor

Li¹,

Tang²,

Huang³

et al. 2022

Transl Cancer Res TCR

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Background: Wilms tumor is the most common childhood kidney malignant tumor. However, the genes and signaling pathways associated with the disease remain incompletely understood.Methods: GSE66405, GSE73209, and GSE11151 were collected from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) were detected using R software. A proteinprotein interaction (PPI) network was constructed using the STRING database, and the clustering modules and hub genes were analyzed with the Cytoscape software. Genes functional enrichment analyses were performed using the package "clusterProfiler" in R software, and the gene set enrichment analysis (GSEA) analysis was performed using GSEA v4.1.0 software.Results: Respectively, 3,092, 620, and 3,567 DEGs were screened in GSE66405, GSE73209, and GSE11151, with a total of 474 common DEGs detected in three expression profiles. For the common DEGs, the top 30 significant results of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways enrichment analyses were presented. Furthermore, five modules were found as the most related modules to Wilms tumor. GO term and KEGG pathway enrichment analyses of the genes in all the modules identified 10 GO terms and 5 KEGG pathways as significantly enriched. The top 10 hub DEGs of the PPI network were ALB, CDH1, EGF, AQP2, REN, SLC2A2, SPP1, UMOD, NPHS2, and FOXM1, with ALB identified as the highest degree. GSEA results showed 11 pathways were correlated with ALB expression in GSE66405 and 10 pathways were related to the expression of the ALB gene in GSE73209.Conclusions: Our study revealed robust gene signatures in Wilms tumor. Dysregulations of the signaling pathways were associated with the development and progression of the Wilms tumor, and 10 hub genes may play important roles in its diagnosis and therapy.

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Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis and identification of genes and pathways involved in patients with Wilms tumor

Li¹,

Tang²,

Huang³

et al. 2022

Transl Cancer Res TCR

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“…[ 5 ] The association of Wilms tumor with genitourinary anomalies like horseshoe kidneys is well known in the literature. [ 1 , 6 ] However, the occurrence of Wilms tumor in orthotopic kidneys with cross-fused renal ectopia is reported as outstandingly rare in children.…”

Section: Discussionmentioning

confidence: 99%

“…The occurrence of Wilms tumor with various congenital anomalies is well known. [ 1 ] Crossed fused renal ectopia is a rare congenital malformation wherein both kidneys are present unilaterally and fused. The incidence of crossed-fused renal ectopia has been reported to be approximately 1:1000 live births.…”

Section: Introductionmentioning

confidence: 99%

Association of Wilms Tumor with Crossed Fused Renal Ectopia in Children: A Case Report

Ali,

Latif,

Sheikh

et al. 2023

J Cancer Allied Spec

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Introduction: Wilms tumor is the most common renal malignancy in children. The occurrence of Wilms tumor with various congenital genitourinary anomalies has been reported, particularly in horseshoe kidneys, hypospadias, disorder of sexual development, and double collecting system. However, Wilms tumor with crossed renal ectopia is a rare finding. Case Description: We are reporting a case report of Wilms tumor in a 3-year-old girl who presented with a huge left flank mass with cross-fused renal ectopia. After the initial workup and triphasic computed tomography (CT) scan of the chest, abdomen, and pelvis for confirmation of diagnosis and metastasis, the patient underwent image-guided tissue biopsy followed by neo-adjuvant chemotherapy, left radical nephrectomy with separation of fused right ectopic renal moiety and adjuvant chemoradiation. Practical Implication: This report shows an association of Wilms tumor with cross-fused renal ectopia, a rare combination. Unusual findings on imaging with unilateral flank mass should be considered as part of the differential diagnosis for this rare finding. Adjuvant chemotherapy and modern imaging helped delineate the anatomy and ease the surgery for safe resection, improving the overall outcome.

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“…Wilms' tumour is the common renal malignancy in children less than five years old and it accounts for approximately 95 percent of all cases diagnosed before the age of four with the peak incidence in the age range of 2 -5 years [1] [2]. Primarily, Wilms' tumour is a sporadic disease and only 1% to 2% of patients with Wilms tumour have a relative with the disease [3] [4].…”

Section: Introductionmentioning

confidence: 99%

Surgical Treatment of Nephroblastoma in a 4-Year Male Child: A Case Report and Literature Review

Egote,

Blay,

Egote

et al. 2024

CRCM

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Herein we report a patient with nephroblastoma which was successfully removed at the Sunyani Teaching Hospital CJ Oppong theatre in Ghana in sub-Saharan Africa by extended below umbilical incision. Our patient had a family history of Wilms tumour predisposing him to the disease. His main symptoms were haematuria and abdominal mass which was noticed later. Examination and investigation were suggestive of a late-stage unilateral Nephroblastoma resulting in the need for nephrectomy. To reduce the need for such radical surgeries among children at an early stage, there is the need for early screening of children for Wilms tumours especially, those with family predisposition as in our case study. The case report presented here constitutes a rare case of nephroblastoma in the literature.

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Wilms’ Tumor in Horseshoe Kidney

Cited by 6 publications

References 18 publications

Bioinformatics analysis and identification of genes and pathways involved in patients with Wilms tumor

Bioinformatics analysis and identification of genes and pathways involved in patients with Wilms tumor

Association of Wilms Tumor with Crossed Fused Renal Ectopia in Children: A Case Report

Surgical Treatment of Nephroblastoma in a 4-Year Male Child: A Case Report and Literature Review

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