Wilms' Tumor of the uterus: The first report of the literature

Bittencourt, Achiléa Lisboa; Britto, José Frederico; Fonseca, Luciano Espinheira

doi:10.1002/1097-0142(19810515)47:10<2496::aid-cncr2820471031>3.0.co;2-v

Cited by 40 publications

(7 citation statements)

References 8 publications

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“…Primary extrarenal Wilms tumors (not associated with a teratoma/germ cell tumor) may arise from metanephric remnants; this is supported by the description of extrarenal Wilms tumors in association with nephrogenic rests (similar to renal Wilms tumors) as well as the association of some extrarenal Wilms tumors with horseshoe kidneys 44–48. The occurrence of primary extrarenal Wilms tumors in testis/paratestis, ovary, and uterus suggests that some extrarenal Wilms tumors may arise from mesonephric remnants 46,49–67. Indeed, the development of human kidney comprises three sequential and overlapping systems arising from the intermediate mesoderm—the pronephros corresponding to the kidney system in lower vertebrates; the mesonephros corresponding to the kidney system in fishes and amphibians; and the metanephros that forms the permanent kidney in higher vertebrates.…”

Section: Discussionmentioning

confidence: 82%

“…[44][45][46][47][48] The occurrence of primary extrarenal Wilms tumors in testis/paratestis, ovary, and uterus suggests that some extrarenal Wilms tumors may arise from mesonephric remnants. 46,[49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66][67] Indeed, the development of human kidney comprises three sequential and overlapping systems arising from the intermediate mesoderm-the pronephros corresponding to the kidney system in lower vertebrates; the mesonephros corresponding to the kidney system in fishes and amphibians; and the metanephros that forms the permanent kidney in higher vertebrates. During human fetal development, the pronephros, in the cervical region, appears at the beginning of the fourth week and disappears by the end of the fourth week.…”

Section: Discussionmentioning

confidence: 99%

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Extrarenal Anaplastic Wilms Tumor: A Case Report With Genomic Analysis and Tumor Models

Willis¹,

Sathe

Xing

et al. 2022

Journal of Pediatric Hematology/Oncology

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Primary extrarenal Wilms tumors are rare neoplasms that are presumed to arise from metanephric or mesonephric remnants outside of the kidney. Their pathogenesis is debated but has not been studied, and there are no reports of genomic descriptions of extrarenal Wilms tumors. We describe a diffusely anaplastic extrarenal Wilms tumor that occurred in the lower abdomen and upper pelvis of a 10-year-old boy. In addition to the clinical, histopathologic, and radiologic features, we describe the cytogenetic changes and exomic profile of the tumor. The tumor showed loss of the tumor suppressor AMER1, loss of chromosome regions 1p, 16q, and 22q, gain of chromosome 8, and loss of function TP53 mutation-findings known to occur in renal Wilms tumors. This is the first description of the exomic profile of a primary extrarenal Wilms tumor. Our data indicate that primary extrarenal Wilms tumors may follow the same pathogenetic pathways that are seen in renal Wilms tumors. Finally, we describe the establishment of first ever tumor models (primary cell line and patient-derived xenograft) from an extrarenal Wilms tumor.

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Extrarenal Anaplastic Wilms Tumor: A Case Report With Genomic Analysis and Tumor Models

Willis¹,

Sathe

Xing

et al. 2022

Journal of Pediatric Hematology/Oncology

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“…Primary Wilms tumor of the gynecologic tract is extremely rare with scattered case reports (6)(7)(8)(9)(10)(11)(12). Review of the nine published cases of primary ovarian Wilms tumor demonstrates that the mean patient age was 21 years (range 1-56) (13)(14)(15)(16)(17)(18)(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

“…Extrarenal Wilms tumors are rare and have been described in various locations including perirenal, lumbar, sacrococcygeal and pelvic areas (5). Few case reports have described primary Wilms tumors of the gynecologic tract, mainly occurring in the uterine corpus and cervix (6)(7)(8)(9)(10)(11)(12). Nine cases of primary ovarian Wilms tumor have been reported to date (13)(14)(15)(16)(17)(18)(19)(20)(21), only one of which was associated with teratoma (13).…”

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confidence: 99%

Wilms Tumor of the Ovary: Review of the Literature and Report of 2 Cases

Turashvili

Fix

Soslow

et al. 2020

International Journal of Gynecological Pathology

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Primary extrarenal Wilms tumor of the gynecologic tract is extremely rare with scattered case reports occurring in the ovary, uterine corpus and cervix. Only nine cases of primary ovarian Wilms tumor have been reported to date. Here, we provide an extensive literature review and describe two patients with ovarian Wilms tumor: a 36-year-old female (patient 1) and a 16-yearold female (patient 2), both presenting with abdominal pain and suspected ovarian torsion. They were each found to have unilateral ovarian masses measuring greater than 15 cm in size which were removed by unilateral salpingo-oophorectomy. Microscopically, the tumors exhibited the typical triphasic histology of Wilms tumor. In addition, the tumor from patient 1 contained elements of mature cystic teratoma, while an extensive rhabdomyosarcomatous component was identified in patient 2. Both tumors were diffusely and strongly positive for WT1 with variable staining for other biomarkers. The cases were diagnostically challenging and referred to our center for an expert opinion. Teratoid Wilms tumor in patient 1 is the second reported case of ovarian Wilms tumor arising in association with teratoma. Recognition of primary ovarian Wilms tumor requires a high index of suspicion and exclusion of other entities based on tumor morphology and immunohistochemical studies.

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“…prostate, 3 sigmoid mesocolon, 4 testis, 5 inguinal canal, 6 mediastinum, 7 chest wall, 8 uterus, [9][10][11][12][13][14][15][16][17][18][19][20][21] ovary. 18,[22][23][24][25][26] Here we report a case of uterine Wilms' tumor with a comprehensive literature review of ERWTs in the female genital system.…”

Section: Ilms' Tumor (Wt)mentioning

confidence: 99%

Extrarenal Wilms’ Tumor of the Female Genital System: A Case Report and Literature Review△

Cao¹,

Huang²,

Wang³

et al. 2017

Chinese Medical Sciences Journal

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Extrarenal Wilms' Tumors (ERWTs) are rare. There have been only 25 cases of ERWT arising from the female genital system reported in the literature. In this paper, we report a 60-year-old woman with a complaint of vaginal bleeding and a polypoid mass in the uterine cavity by sonography that was demonstrated as ERWT by pathology after resection. The pathological characteristics, histological origination, diagnosis, therapy and prognosis of ERWT in female reproductive system are discussed in this paper in the purpose of improving the diagnosis and therapy of this rare tumor.

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Wilms' Tumor of the uterus: The first report of the literature

Cited by 40 publications

References 8 publications

Extrarenal Anaplastic Wilms Tumor: A Case Report With Genomic Analysis and Tumor Models

Extrarenal Anaplastic Wilms Tumor: A Case Report With Genomic Analysis and Tumor Models

Wilms Tumor of the Ovary: Review of the Literature and Report of 2 Cases

Extrarenal Wilms’ Tumor of the Female Genital System: A Case Report and Literature Review△

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