2008
DOI: 10.1016/j.ejca.2008.01.008
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Wilms’ tumour 1 gene expression is increased in hepatocellular carcinoma and associated with poor prognosis

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Cited by 44 publications
(38 citation statements)
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“…To this end, we examined three HCC samples with high and three HCC samples with low WT1 mRNA levels. In agreement with a recent report (10) describing a close correlation between WT1 mRNA and protein expression in liver tumors, we found that those HCC samples with higher WT1 mRNA levels also showed enhanced WT1 immunostaining. These observations, together with our previous findings in chronic hepatitis and cirrhosis (9), indicate that WT1 expression in the liver is associated with chronic tissue injury and neoplastic transformation, situations in which liver parenchymal cells display enhanced proliferation.…”
Section: Resultssupporting
confidence: 82%
See 1 more Smart Citation
“…To this end, we examined three HCC samples with high and three HCC samples with low WT1 mRNA levels. In agreement with a recent report (10) describing a close correlation between WT1 mRNA and protein expression in liver tumors, we found that those HCC samples with higher WT1 mRNA levels also showed enhanced WT1 immunostaining. These observations, together with our previous findings in chronic hepatitis and cirrhosis (9), indicate that WT1 expression in the liver is associated with chronic tissue injury and neoplastic transformation, situations in which liver parenchymal cells display enhanced proliferation.…”
Section: Resultssupporting
confidence: 82%
“…In this work, we show that WT1 is also expressed in tumor tissue in a high proportion of patients with hepatocellular carcinoma (HCC), a finding that is in agreement with a very recent report from Japan showing positive immunohistochemical staining in 95% of HCC specimens (10). Although in this report, the authors observed a correlation between WT1 expression and patient survival, there are no data showing the implication of WT1 in HCC biology.…”
Section: Introductionsupporting
confidence: 73%
“…There is little controversy regarding the observation that solid cancers of non-mesodermal origin rarely show nuclear immunostaining but frequently exhibit cytoplasmic immunostaining, while mesodermal tissues provide the nuclear immunostaining (8)(9)(10)(11)(12)(13)(14)(15)(16)(18)(19)(20)(21)(22)(23)(24)28). Differences of the conclusions about WT1 expression in non-mesodermal solid cancers stem largely from a discrepancy in interpretations of the cytoplasmic immunostaining.…”
Section: Discussionmentioning
confidence: 99%
“…WT1 was prioritized as a promising target of immunotherapy against various malignancies (17) because dozens of studies have confirmed WT1 overexpression not only in mesodermally derived malignancies but also in a variety of non-mesodermal origin solid cancers such as esophageal (45-95%) (18,19), gastric (42%) (19), colon (69-89%) (19,20), hepatocellular (95%) (21), bile duct (68%) (19), pancreatic (65-75%) (19,22), thyroid (95%) (23), prostate (25%) (9), lung (30-83%) (19,24), breast (26-87%) (19,(25)(26)(27), Tissue samples. Cancer tissues and corresponding normal epithelial tissues were obtained from 552 patients with esophageal (101 patients), bile duct (96 patients), pancreatic (99 patients), and lung cancer (256 patients) who underwent resection in the Department of Gastroenterological surgery II, hokkaido University, Japan between 1994 and 2005.…”
Section: Introductionmentioning
confidence: 99%
“…Several works investigated antigen specific immunotherapy against potential tumor-associated antigens (TAAs) in HCC, including alpha-fetoprotein (AFP) (10)(11), carcinoembryonic antigen (CEA) (12), glypican-3 (GPC3) (13), Wilm's tumor 1 gene (WTl) (14), cancer testis antigen NY-ESO-l (15) and melanoma-associated antigens (MAGE) (16). In particular, AFP is an oncofetal protein whose expression level is increased in many primary liver tumors; as a result, elevated serum levels of AFP may serve as a liver tumor marker (11).…”
mentioning
confidence: 99%