The aim of this study is to assess wind-induced torsional loads on low- and medium-rise buildings determined in accordance with the National Building Code of Canada (NBCC 2010). Two building models with the same horizontal dimensions but different gabled-roof angles (0° and 45°) were tested at different full-scale equivalent eave heights (6, 12, 20, 30, 40, 50, and 60 m) in open terrain exposure for several wind directions (every 15°). Wind-induced measured pressures were numerically integrated over all building surfaces and results were obtained for along-wind force, across-wind force, and torsional moment. Torsion load case (i.e., maximum torsion and corresponding shear) and shear load case (i.e., maximum shear and corresponding torsion) were evaluated to reflect the maximum actual wind load effects in the two horizontal directions (i.e., transverse and longitudinal). The evaluated torsion and shear load cases were also compared with the current torsion- and shear-related provisions in the NBCC 2010. The results demonstrated significant discrepancies between NBCC 2010 and the wind tunnel measurements regarding the evaluation of torsional wind loads on low- and medium-rise buildings. Finally, shear and torsion load cases were suggested for evaluating wind loads in the design of low- and medium-rise rectangular buildings.