Since the power generation structures and load characteristics in each province in China are quite different, the distribution of peak regulating resources and demands are extremely imbalance. Restricted by a low power marketization degree, peak regulating resource shortages, and transmission channel blocks, the efficient utilization of new energy is facing greater pressures. In order to improve the mutual aid in regional power grids and to obtain more precise simulation results, this paper proposes a two-layer optimization dispatching model, considering the mutual aid of peak regulation resources between each province. It determines the optimal startup mode and the units’ power output in each province and obtains the power output arrangements for all the units and the technical and economic indicators. The model and the solution method are original and innovative. And it effectively solved the unequal distribution problem between the peak regulating demands and resources of each provincial power grid. Finally, taking an actual regional power grid in China as an example, the simulation results show that the proposed model can significantly improve the utilization rate of new energy, which verifies the effectiveness and feasibility of the proposed model and methods presented in this paper.