Wind turbines and adverse health effects: Applying Bradford Hill's criteria for causation by Anne Dumbrille, Robert McMurtry, and Carmen Krogh – 'Big noises: Tobacco and Wind'

Evans, Alun

doi:10.4103/ed.ed_24_21

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…A possible disturbance of microcirculation is discussed. A positive evaluation in this direction is also the metanalysis Dumbrille, A et al (2021) [59]: This evaluation results in the causality of adverse health effects (ADH's) and the stressor in all "Bradford Hill criteria".…”

Section: Positive Support For Evidencementioning

confidence: 99%

Impairment of the Endothelium and Disorder of Microcirculation in Humans and Animals Exposed to Infrasound due to Irregular Mechano-Transduction

Bellut-Staeck

2023

JBM

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The microcirculation of mammals is an autoregulated and complex synchronised system according to the current demand for nutrients and oxygen. The undisturbed course of vital functions such as of growth, blood pressure regulation, inflammatory sequence and embryogenesis is bound to endothelial integrity. The sensible vasomotion is particularly dependent on it. Mechanotransduction signalling networks play a critical role in vital cellular processes and are the decisive physiological mechanism for an adequate NO-release, main responsible for the autoregulation of vessels. Disturbed endothelial integrity, originating, e.g., from chronic oxidative stress and/or mechanic (oscillatory) stress, leads to disturbance of vasomotion as well as a disequilibrium of redox systems, recognized as main cause for the development of chronic inflammation diseases such as atherosclerosis and corresponding secondary illnesses, possibly cancer. The endothelial cytoskeleton, which corresponds to a viscoelastic "tensegrity model", offers the possibility for mechano-transduction via its special construction. The rapidly growing knowledge about mechanical forces in cellular sensing and regulation of the last years (that culminated in the Nobel Prize award for the decoding of pressure/vibration sensing ion channels), led us to the following hypothesis: The extern stressor "Noise" produces under certain conditions an oscillatory stress field in the physiologically laminar flow bed of capillaries, which is able to lead to irregular mechano-transductions. Findings provide a strict dependence on frequency in mechano-transduction with determination of thresholds for a 1:1 transmission. The knowledge, recently gained on endothelial mechano-transduction, sheds a new light on the importance of low frequencies. This could indicate the long-sought pathophysiological way in which infrasound can exert a stressor effect at the cellular level. Noise-exposed citizens, who live near infra-How to cite this paper: Bellut-Staeck, U.M. (2023) Impairment of the Endothelium and Disorder of Microcirculation in Humans and Animals Exposed to Infrasound due to Irregular Mechano-Transduction.

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Section: Positive Support For Evidencementioning

confidence: 99%

Impairment of the Endothelium and Disorder of Microcirculation in Humans and Animals Exposed to Infrasound due to Irregular Mechano-Transduction

Bellut-Staeck

2023

JBM

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“…Nicht erwähnt wird u. a. die Arbeit von Dumbrille et al 2 sowie das Editorial von Evans 3 dazu. Die Bradford-Hill-Kriterien sind aber weit verbreitet, um Kausalität zwischen einer Umwelteinwirkung und dem Krankheitsrisiko festzustellen.…”

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Zum Beitrag „Windenergieanlagen und Infraschall: Keine Evidenz für gesundheitliche Beeinträchtigungen – eine physikalische, medizinische und gesellschaftliche Einordnung“

Mathys¹,

Friesen²,

Schmonsees³

2022

Dtsch Med Wochenschr

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Wind turbines and adverse health effects: Applying Bradford Hill's criteria for causation by Anne Dumbrille, Robert McMurtry, and Carmen Krogh – 'Big noises: Tobacco and Wind'

Cited by 2 publications

References 6 publications

Impairment of the Endothelium and Disorder of Microcirculation in Humans and Animals Exposed to Infrasound due to Irregular Mechano-Transduction

Impairment of the Endothelium and Disorder of Microcirculation in Humans and Animals Exposed to Infrasound due to Irregular Mechano-Transduction

Zum Beitrag „Windenergieanlagen und Infraschall: Keine Evidenz für gesundheitliche Beeinträchtigungen – eine physikalische, medizinische und gesellschaftliche Einordnung“

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