Windows of sensitivity to toxic chemicals in the development of the endocrine system: an analysis of ATSDR’s toxicological profile database

Buser, MC; Pohl, HR; Abadin, HG

doi:10.1080/09603123.2020.1772204

Cited by 4 publications

(2 citation statements)

References 125 publications

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“…In addition, it is current opinion that each organ and axis, in particular the endocrine ones, have a specific temporal window of sensitivity to chemicals that accounts for any difference in the toxic effects measured. These sensitive windows also differ between humans and other animal models [ 91 ] and may also be affected by genetic sex as influenced by sex hormone production. Thus, in vitro differentiated ESCs or iPSCs may not reflect the sensitivity stage of development, thus potentially affecting the validity of the obtained toxicity results.…”

Section: Human-relevant Nams For Developmental Toxicity Testingmentioning

confidence: 99%

Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto–Placental Organ-on-Chip Platform

Luconi

Sogorb

Markert

et al. 2022

IJERPH

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Developmental toxicity testing urgently requires the implementation of human-relevant new approach methodologies (NAMs) that better recapitulate the peculiar nature of human physiology during pregnancy, especially the placenta and the maternal/fetal interface, which represent a key stage for human lifelong health. Fit-for-purpose NAMs for the placental–fetal interface are desirable to improve the biological knowledge of environmental exposure at the molecular level and to reduce the high cost, time and ethical impact of animal studies. This article reviews the state of the art on the available in vitro (placental, fetal and amniotic cell-based systems) and in silico NAMs of human relevance for developmental toxicity testing purposes; in addition, we considered available Adverse Outcome Pathways related to developmental toxicity. The OECD TG 414 for the identification and assessment of deleterious effects of prenatal exposure to chemicals on developing organisms will be discussed to delineate the regulatory context and to better debate what is missing and needed in the context of the Developmental Origins of Health and Disease hypothesis to significantly improve this sector. Starting from this analysis, the development of a novel human feto–placental organ-on-chip platform will be introduced as an innovative future alternative tool for developmental toxicity testing, considering possible implementation and validation strategies to overcome the limitation of the current animal studies and NAMs available in regulatory toxicology and in the biomedical field.

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Section: Human-relevant Nams For Developmental Toxicity Testingmentioning

confidence: 99%

Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto–Placental Organ-on-Chip Platform

Luconi

Sogorb

Markert

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…In addition, it is current opinion that each organ and axis, in particular the endocrine ones, have a specific temporal window of sensitivity to chemicals that accounts for any difference in the toxic effects measured. These sensitive windows also differ between humans and other animal models [90], and may also be affected by genetic-sex as influenced by sex hormone production. Thus, in vitro differentiated ESCs or iPSCs may not reflect the sensitivity stage of development, thus potentially affecting the validity of the obtained toxicity results.…”

Section: Human Relevant Nams For Embryonic/fetal Toxicologymentioning

confidence: 99%

Human-based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State-of-the-art with a Feto-placental Organ-on-a-chip Platform

Luconi¹,

Sogorb²,

Markert³

et al. 2022

Preprint

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Developmental toxicity testing urgently requires the implementation of human relevant new approach methodologies (NAMs) that better recapitulate the peculiar nature of human physiology during pregnancy, especially the placenta and the maternal/fetal interface, which represent a key stage for the human lifelong health. Fit-for-purpose NAMs for the placental-fetal interface are desirable to improve the biological knowledge of environmental exposure at molecular level and to reduce the high cost, time and ethical impact of animal studies. This article reviews the state of the art on the available in vitro (placental, fetal and amniotic cell-based systems) and in silico NAMs of human relevance for developmental toxicity testing purposes, as well as of the available Adverse Outcome Pathways related to developmental toxicity. The OECD TG 414 for the identification and assessment of deleterious effects of prenatal exposure to chemicals on developing organisms will be discussed to delineate the regulatory context and to better debate what is missing and needed in the context of the developmental origins of health and disease hypothesis to significantly improve this sector. Starting from this analysis, the development of a novel human feto-placental organ-on-chip platform will be introduced as an innovative alternative tool for developmental toxicity testing, considering possible implementation and validation strategies to overcome the limitation of the current animal studies and NAMs available in regulatory toxicology and in the biomedical field.

show abstract

Eco-toxicological impacts of industrial wastewater and the role of bio-electrochemical systems (BES) in remediation: a review

Usman,

Zhao,

Yemele

et al. 2024

Clean Techn Environ Policy

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Windows of sensitivity to toxic chemicals in the development of the endocrine system: an analysis of ATSDR’s toxicological profile database

Cited by 4 publications

References 125 publications

Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto–Placental Organ-on-Chip Platform

Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto–Placental Organ-on-Chip Platform

Human-based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State-of-the-art with a Feto-placental Organ-on-a-chip Platform

Eco-toxicological impacts of industrial wastewater and the role of bio-electrochemical systems (BES) in remediation: a review

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