This study examined the effects of providing reading strategy instruction to improve the effectiveness of self-explanation (i.e., explaining the meaning of information to oneself while reading). The effects of the reading strategy instruction, called Self-Explanation Reading Training (SERT), were examined both in terms of comprehension scores and self-explanation quality. Half of the participants (n = 42) received SERT, which included reading strategy instruction and self-explanation practice with 4 science texts (SERT condition). The remaining participants read aloud the 4 science texts (control condition). During this training phase, self-explanation, as compared to reading aloud, only improved comprehension for the most difficult of the 4 texts. Prior domain knowledge consistently improved comprehension performance, whereas reading skill and reading span had minimal effects. After training, both SERT and control participants self-explained a difficult text about cell mitosis. SERT improved comprehension and self-explanation quality only for participants with low domain knowledge. However, the effects of SERT on low-knowledge participants' comprehension emerged only for text-based questions and not for bridging-inference questions. Protocol analyses indicated that SERT helped these participants to use logic, or domain-general knowledge, rather than domain-specific knowledge to make sense of the text.Understanding and learning from written material is one of the most important skills to possess in modern society. The importance of understanding text ranges from being able to decipher the "three easy steps" for setting up your computer to understanding the ever-dreaded physiology textbook. Indeed, the ability to comprehend the challenging textbooks confronted in typical classrooms is one of the