Wine and its metabolic effects. A comprehensive review of clinical trials

Fragopoulou, Elizabeth; Choleva, Maria; Antonopoulou, Smaragdi; Demopoulos, Constantinos A.

doi:10.1016/j.metabol.2018.01.024

Cited by 60 publications

(62 citation statements)

References 95 publications

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“…Our results re ect those of most researchers (12)(13)(14). The inverse relationship between brinogen concentrations and alcohol consumption is attributed mainly to ethanol (12), but the possibility of the result being from the ingredients accompanying ethanol in alcoholic beverage, or to their synergistic effect, is plausible. Early animal studies suggested that ethanol may interfere with hepatic plasma protein synthesis.…”

Section: Discussionsupporting

confidence: 87%

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The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes

Rautenbach

Nienaber-Rousseau

Pieters

2020

Preprint

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Background Alcohol consumption is associated with haemostasis and so may influence cardiovascular conditions. It is unknown whether the association of alcohol with total and γ’ fibrinogen concentrations, as well as clot structure, are modulated by fibrinogen and factor (F)XIII single nucleotide polymorphisms (SNPs). Methods Total fibrinogen, γ’ fibrinogen and clot properties of 2010 healthy black South Africans were measured in relation to alcohol intake as well as its markers – gamma-glutamyltransferase (GGT), percentage carbohydrate deficient transferrin (%CDT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). Fourteen fibrinogen and two SNPs in the FXIII gene were genotyped to determine their influence. Results Alcohol intake and its markers correlated negatively with fibrinogen and clot lysis time (CLT) as well as with most of the clot properties. Percentage γ’ fibrinogen correlated positively with AST and negatively with alcohol intake. We then stratified for alcohol intake and found inverse associations between γ’ fibrinogen and both %CDT and GGT–CDT in consumers, but the positive association with AST remained only in abstainers. Alcohol intake and its markers modulated the influence of fibrinogen SNPs on total fibrinogen concentrations and the fibrinogen SNPs as well as an FXIII SNP on clot density (all p <0.004). Conclusion/s We show for the first time that some individuals harbour certain genotypes that, in combination with alcohol consumption, might predispose or protect them from haemostatic factors that might lead to the development of cardiovascular disease. Studies are needed to clarify the mechanisms related to the interplay between alcohol and gene variants observed here.

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Section: Discussionsupporting

confidence: 87%

“…(10) Moderate alcohol consumption reduces total brinogen concentrations. (11)(12)(13)(14) However, whether alcohol intake in uences γ' brinogen is unknown. Moreover, the impact of alcohol on the properties of blood clots is complex and also remains to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes

Rautenbach

Nienaber-Rousseau

Pieters

2020

Preprint

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Section: Discussionmentioning

confidence: 99%

“…A recent review of clinical trials assessing the effects of wine consumption revealed a significant impact on lipid metabolism mostly attributed to their ethanol content . Although the beneficial effect of moderate alcohol consumption on HDL metabolism is well described, the effect of wine consumption on TAGs, LDL, VLDL, and lipoprotein(a) is still under debate . In fact, a J‐shaped relationship between alcohol intake and plasma TAGs has been consistently reported, but no studies have ever reported any association between plasma TAG species with RW consumption.…”

Section: Discussionmentioning

confidence: 99%

“…[5] Although the beneficial effect of moderate alcohol consumption on HDL metabolism is well described, the effect of wine consumption on TAGs, LDL, VLDL, and lipoprotein(a) is still under debate. [5] In fact, a Jshaped relationship between alcohol intake and plasma TAGs has been consistently reported, [28] but no studies have ever reported any association between plasma TAG species with RW consumption. In our study, the highest negative coefficient identified was found for C51:3 TAG.…”

Section: Discussionmentioning

confidence: 99%

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Plasma Metabolites Associated with Frequent Red Wine Consumption: A Metabolomics Approach within the PREDIMED Study

Hernández‐Alonso

Papandreou

Bulló

et al. 2019

Molecular Nutrition Food Res

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Scope The relationship between red wine (RW) consumption and metabolism is poorly understood. It is aimed to assess the systemic metabolomic profiles in relation to frequent RW consumption as well as the ability of a set of metabolites to discriminate RW consumers. Methods and results A cross‐sectional analysis of 1157 participants is carried out. Subjects are divided as non‐RW consumers versus RW consumers (>1 glass per day RW [100 mL per day]). Plasma metabolomics analysis is performed using LC–MS. Associations between 386 identified metabolites and RW consumption are assessed using elastic net regression analysis taking into consideration baseline significant covariates. Ten‐cross‐validation (CV) is performed and receiver operating characteristic curves are constructed in each of the validation datasets based on weighted models. A subset of 13 metabolites is consistently selected and RW consumers versus nonconsumers are discriminated. Based on the multi‐metabolite model weighted with the regression coefficients of metabolites, the area under the curve is 0.83 (95% CI: 0.80–0.86). These metabolites mainly consisted of lipid species, some organic acids, and alkaloids. Conclusions A multi‐metabolite model identified in a Mediterranean population appears useful to discriminate between frequent RW consumers and nonconsumers. Further studies are needed to assess the contribution of these metabolites in health and disease.

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The effect of grapes/grape products on glycemic response: A systematic review and meta‐analysis of randomized controlled trials

Moodi

Abedi

Esmaeilpour

et al. 2021

Phytotherapy Research

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The aim of this study was to perform a systematic review and meta‐analysis of randomized clinical trials (RCTs) to examine the effect of grapes/grape products supplementation on glycemic indices in adults. Our systematic search to find relevant RCTs was performed up to February 2020 using PubMed, Scopus, ISI Web of Science, Cochrane Library, and Google Scholar. Based on the heterogeneity between included studies, a random effects or a fixed model was applied in the meta‐analysis, and results were expressed as weighted mean differences (WMD) with 95% confidence intervals (CI). Twenty‐nine clinical trials (1,297 participants) fulfilled the eligibility criteria of the present meta‐analysis. Overall, the grapes/grape products supplementation significantly reduced homeostatic model assessment of insulin resistance (HOMA‐IR) (WMD: −0.54, 95% CI: −0.91, −0.17, p = . 004) but did not affect fasting insulin levels (WMD: −0.90 μIU/ml, 95% CI: −1.04, 2.84, p = .362) and hemoglobin A1C (Hb1Ac) percentage (WMD: 0.00%, 95% CI: −0.10, 0.11, p = . 916) in the main analyses. In addition, changes to fasting blood glucose (FBG) levels were in favor of the control group (WMD: 1.19 mg/dl, 95% CI: 0.05, 2.34, p = .041). We found that giving grapes/grape products to adults might have beneficial effects on the HOMA‐IR. Further, large‐scale RCTs with longer duration are required to confirm these results.

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Wine and its metabolic effects. A comprehensive review of clinical trials

Cited by 60 publications

References 95 publications

The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes

The association of alcohol with circulating total fibrinogen and plasma clot density is mediated by fibrinogen and FXIII genotypes

Plasma Metabolites Associated with Frequent Red Wine Consumption: A Metabolomics Approach within the PREDIMED Study

The effect of grapes/grape products on glycemic response: A systematic review and meta‐analysis of randomized controlled trials

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