Wine stimulates gastric acid secretion in isolated rabbit gastric glands via two different pathways

Matsuno, Kuniharu; Tomita, Kazuyoshi; Okabe, S

doi:10.1046/j.1365-2036.16.s2.9.x

Cited by 6 publications

(5 citation statements)

References 18 publications

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“…reported that alcohol consumption significantly lowered treatment efficacy (70% among drinkers vs. 90% among nondrinkers, p = 0.004) [6]. The possible mechanism stems from the stimulation of histamine release, gastric acid secretion [22,23], and a change of intragastric microenvironment that influences the stability of antibiotics or enhances the growth of H. pylor i [24]. However, such differences were not seen in our study (presence vs. absence of alcohol consumption: 84.38% vs. 86.92%, p = 0.34).…”

Section: Discussioncontrasting

confidence: 66%

Randomized trial comparing rabeprazole‐ versus lansoprazole‐based Helicobacter pylori eradication regimens

Liu

et al. 2013

The Kaohsiung J of Med Scie

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Different types of proton pump inhibitor (PPI)-based triple therapies could result in different Helicobacter pylori eradication rates. This study aimed to compare the efficacy and safety of rabeprazole- and lansoprazole-based triple therapies in primary treatment of H. pylori infection. From September 2005 to July 2008, 426 H. pylori-infected patients were randomly assigned to receive a 7-day eradication therapy with either rabeprazole 20mgbid (RAC group, n=222) or lansoprazole 30mgbid (LAC group, n=228) in combination with amoxicillin 1gbid and clarithromycin 500mgbid. The patients received follow-up esophagogastroduodenoscopy (EGD) and/or (13)C-urea breath test 12-16 weeks later to define H. pylori status. Their personal and medical history, compliance and side effects were obtained by using a standardized questionnaire. Intention-to-treat analysis revealed that the eradication rate was 87.84% in the RAC group and 85.96% in the LAC group (p=0.56). All patients returned for assessment of compliance (100% in the LAC group vs. 99.50% in the RAC group; p=0.32) and adverse events (7.20% in the RAC group vs. 5.70% in the LAC group, p=0.51). Univariate analysis suggested that patients with nonsteroid anti-inflammatory agent (NSAID) use had lower eradication rates than those without (76.71% vs. 88.74%; p=0.006). Our results showed that efficacy and safety were similar in rabeprazole- and lansoprazole-based primary therapies. The influence of NSAID usage on H. pylori eradication needs to be further investigated.

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Section: Discussioncontrasting

confidence: 66%

Randomized trial comparing rabeprazole‐ versus lansoprazole‐based Helicobacter pylori eradication regimens

Liu

et al. 2013

The Kaohsiung J of Med Scie

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“…In the past few decades, several studies have investigated the influence of alcoholic beverages on gastric acid secretion using intragastric titration in humans − , as well as in animals, such as rats or dogs, or in isolated gastric glands from rabbits . To our knowledge, there have been only two studies comparing the effect of red wine and white wine on gastric acid secretion.…”

Section: Introductionmentioning

confidence: 99%

“…11 In the past few decades, several studies have investigated the influence of alcoholic beverages on gastric acid secretion using intragastric titration in humans 1 −3,12 as well as in animals, such as rats 13 or dogs, 14 or in isolated gastric glands from rabbits. 15 To our knowledge, there have been only two studies comparing the effect of red wine and white wine on gastric acid secretion. In a human intervention trial, Peterson and colleagues administered 300 mL of either red or white wine to healthy subjects and did not observe any difference in gastric acid secretion.…”

Section: ■ Introductionmentioning

confidence: 99%

Identification of Organic Acids in Wine That Stimulate Mechanisms of Gastric Acid Secretion

Liszt

Walker

Somoza

2012

J. Agric. Food Chem.

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Wine may cause stomach irritation due to its stimulatory effect on gastric acid secretion, although the mechanisms by which wine or components thereof activate pathways of gastric acid secretion are poorly understood. Gastric pH was measured with a noninvasive intragastric probe, demonstrating that administration of 125 mL of white or red wine to healthy volunteers stimulated gastric acid secretion more potently than the administration of equivalent amounts of ethanol. Between both beverages, red wine showed a clear trend for being more active in stimulating gastric acid secretion than white wine (p = 0.054). Quantification of the intracellular proton concentration in human gastric tumor cells (HGT-1), a well-established indicator of proton secretion and, in turn, stomach acid formation in vivo, confirmed the stronger effect of red wine as compared to white wine. RT-qPCR experiments on cells exposed to red wine also revealed a more pronounced effect than white wine on the fold change expression of genes associated with gastric acid secretion. Of the quantitatively abundant organic acids in wine, malic acid and succinic acid most actively stimulated proton secretion in vitro. However, addition of ethanol to individual organic acids attenuated the secretory effect of tartaric acid, but not that of the other organic acids. It was concluded that malic acid for white wine and succinic acid for red wine are key organic acids that contribute to gastric acid stimulation.

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“…For this reason, the delivery of antibiotics to the gastric mucosa is reduced. Other studies have reported that alcohol consumption also decreases the eradication success rate of PPI-based therapy (Hsu et al 2005) by stimulating gastric acid secretion (Tsukimi et al 2001;Matsuno et al 2002). In contrast, recent studies have reported that neither smoking nor alcohol consumption decreases the eradication success rate of vonoprazan-based first-line therapy (Sakurai et al 2017;Takara et al 2019), which can be explained by the more potent inhibition of acid excretion by vonoprazan than by PPI.…”

Section: Discussionmentioning

confidence: 96%

High Body Mass Index Is Correlated with the Success of Vonoprazan-Based Second-Line Therapy for <i>Helicobacter Pylori </i>Infection

Kasai

Suzuki

Kusano

et al. 2021

Tohoku J. Exp. Med.

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Eradication of Helicobacter pylori (Hp) is necessary for preventing peptic ulcers and stomach cancer. The potassium-competitive acid blocker vonoprazan is a gastric acid secretion inhibitor that improves the success rate of Hp eradication through its immediate and persistent inhibition of acid excretion. In Japan, first-line treatment involves a regimen in which vonoprazan is combined with amoxicillin and clarithromycin, while second-line treatment involves vonoprazan combined with amoxicillin and metronidazole. However, in contrast to the vonoprazan-based first-line therapy, no studies have investigated the factors influencing the success of vonoprazan-based second-line therapy. In this study, we therefore aimed to investigate factors related to the success of vonoprazan-based second-line therapy. We analyzed the association between the success of Hp eradication and patient factors including metronidazole/amoxicillin minimal inhibitory concentrations (MICs). MICs were measured using the Hp isolated from each patient. A receiver operating characteristic (ROC) analysis was conducted to examine continuous variables and eradication success. We reviewed the records of 33 patients (age: 34-79 years, male/female: 22/11, and body mass index (BMI): 16.1-28.8 kg/m 2 ) who underwent vonoprazan-based second-line therapy after failure of firstline therapy at seven Japanese facilities between October 2018 and June 2019. The eradication success rate was 81.8% (27/33). ROC analysis revealed an area under the curve and BMI cutoff value of 0.796 and 23.8 kg/m 2 , respectively. The eradication success rate was higher in patients with high BMI than in those with low BMI (p = 0.007). Our findings indicate that higher BMI is correlated with the success of vonoprazan-based second-line therapy.

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Wine stimulates gastric acid secretion in isolated rabbit gastric glands via two different pathways

Cited by 6 publications

References 18 publications

Randomized trial comparing rabeprazole‐ versus lansoprazole‐based Helicobacter pylori eradication regimens

Randomized trial comparing rabeprazole‐ versus lansoprazole‐based Helicobacter pylori eradication regimens

Identification of Organic Acids in Wine That Stimulate Mechanisms of Gastric Acid Secretion

High Body Mass Index Is Correlated with the Success of Vonoprazan-Based Second-Line Therapy for <i>Helicobacter Pylori </i>Infection

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