Wings and stings: Hymenoptera on vacation

Yuan, Irene; Golden, David B.K.

doi:10.1016/j.anai.2023.01.017

Cited by 6 publications

(2 citation statements)

References 61 publications

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“…A large amount of BV can also be deadly in certain cases and death can occur due to the bronchial spasm that arises due to the paralysis of the brain center responsible for breathing. BV in the body causes an immune system reaction which, in hypersensitive individuals, causes allergic reactions that can be very dangerous and can also induce death [ 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ].…”

Section: Bee Venommentioning

confidence: 99%

Bee Venom: Composition and Anticancer Properties

Gajski,

Leonova,

Sjakste

2024

Toxins

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Among the various natural compounds used in alternative and Oriental medicine, toxins isolated from different organisms have had their application for many years, and Apis mellifera venom has been studied the most extensively. Numerous studies dealing with the positive assets of bee venom (BV) indicated its beneficial properties. The usage of bee products to prevent the occurrence of diseases and for their treatment is often referred to as apitherapy and is based mainly on the experience of the traditional system of medical practice in diverse ethnic communities. Today, a large number of studies are focused on the antitumor effects of BV, which are mainly attributed to its basic polypeptide melittin (MEL). Previous studies have indicated that BV and its major constituent MEL cause a strong toxic effect on different cancer cells, such as liver, lung, bladder, kidney, prostate, breast, and leukemia cells, while a less pronounced effect was observed in normal non-target cells. Their proposed mechanisms of action, such as the effect on proliferation and growth inhibition, cell cycle alterations, and induction of cell death through several cancer cell death mechanisms, are associated with the activation of phospholipase A2 (PLA2), caspases, and matrix metalloproteinases that destroy cancer cells. Numerous cellular effects of BV and MEL need to be elucidated on the molecular level, while the key issue has to do with the trigger of the apoptotic cascade. Apoptosis could be either a consequence of the plasmatic membrane fenestration or the result of the direct interaction of the BV components with pro-apoptotic and anti-apoptotic factors. The interaction of BV peptides and enzymes with the plasma membrane is a crucial step in the whole process. However, before its possible application as a remedy, it is crucial to identify the correct route of exposure and dosage of BV and MEL for potential therapeutic use as well as potential side effects on normal cells and tissues to avoid any possible adverse event.

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Section: Bee Venommentioning

confidence: 99%

Bee Venom: Composition and Anticancer Properties

Gajski,

Leonova,

Sjakste

2024

Toxins

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“…Most sting reactions are attributed to Solenopsis invicta, the red imported fire ant, and the second most important is the black imported fire ant, Solenopsis richteri. Bites can occur yearround but are most common in the summer months [65,66]. In less than a century, they have spread via human trade throughout much of the USA, Mexico, the Caribbean, China, Taiwan, and Australia.…”

Section: Formicidae (Ants)mentioning

confidence: 99%

Emerging and Novel Elicitors of Anaphylaxis: Collegium Internationale Allergologicum Update 2024

Treudler

2024

Int Arch Allergy Immunol

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Background: Anaphylaxis represents the most severe end of the spectrum of allergic reactions. Frequent elicitors of anaphylaxis are insects, foods, and drugs. This paper summarizes recent development with regard to emerging and novel elicitors of anaphylaxis. Summary: Food allergens on the rise include pulses (like pea, chickpea), seeds (hemp, chia), nuts (cashew), pseudograins (buckwheat, quinoa), fruits, and microalgae. Novel foods are foods that were not consumed to any significant extent in the European Union before May 1997, which includes four edible insects (mealworm, migratory locust, house cricket, and buffalo worm). Recent investigations have pointed out the risk of anaphylaxis associated with the consumption of yellow mealworm for people allergic to shellfish and house dust mites. In Europe, fire ants (mostly Solenopsis invicta) and Vespa velutina nigrithorax represent invasive species, which account for increasing numbers of anaphylactic reactions. Also, several new drugs, especially biologicals, have been associated with anaphylaxis. Key Messages: Elicitors of anaphylaxis are changing as a result of (i) increase in demand for plant-based food, (ii) introduction of novel foods, (iii) spreading of allergens by climate changes and globalization, or (iv) due to exposure to newly developed drugs.

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Allergies on vacation: It is a small world after all

Shaker¹

2023

Annals of Allergy, Asthma & Immunology

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Wings and stings: Hymenoptera on vacation

Cited by 6 publications

References 61 publications

Bee Venom: Composition and Anticancer Properties

Bee Venom: Composition and Anticancer Properties

Emerging and Novel Elicitors of Anaphylaxis: Collegium Internationale Allergologicum Update 2024

Allergies on vacation: It is a small world after all

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