Winning Formulas to Fulfill Cancer Moonshot

Liau, Ming C.; Fruehauf, John P.

doi:10.33425/2833-0390.1007

Cited by 4 publications

(6 citation statements)

References 20 publications

(26 reference statements)

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“…Drugs approved for the therapy of cancer are predominantly bad cancer drugs, which are responsible for the horrendous cancer mortality of more than 10 million a year worldwide and still on the way to increase by an annual increment of 5% [1]. Good cancer drugs can bring down cancer mortality not only to fulfill President Biden's cancer moonshot initiative of reducing 50% cancer mortality in 25 years [11], but also to win the war on cancer declared by President Nixon in 1971, which bad cancer drugs failed to accomplish [2,12,13]. Somehow cancer establishments are trapped in belief that bad cancer drugs are the right choice for cancer therapy.…”

Section: Good Cancer Drugs Vs Bad Cancer Drugsmentioning

confidence: 99%

“…Cancer establishments set up the rule of tumor reduction as an exclusive criterion of acceptability as cancer drugs that can only allow the approval of bad cancer drugs and exclude good cancer drugs. Now President Biden wanted the health profession to come up solutions to reduce cancer mortality by 50% in 25 years [11]. Health profession has the obligation to develop good cancer drugs to reduce cancer mortality [9].…”

Section: Development Of Cda Formulations As Good Cancer Drugs To Save...mentioning

confidence: 99%

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CDA Formulations as Persuasive Good Cancer Drugs to Save Cancer Patients

Liau,

Craig,

Baker

2024

IJCOCR

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The objective of this study is to develop good cancer drugs to save cancer patients. Good cancer drugs are the drugs capable of inactivating abnormal methylation enzymes (MEs) to take out both cancer stem cells (CSCs) and cancer cells (CCs) by inducing these cells to undergo terminal differentiation, and to restore chemo-surveillance to save cancer patients. Bad cancer drugs are cytotoxic agents that can kill CCs but cannot affect CSCs, which can also destroy chemo-surveillance to contribute to the fatality of advanced cancer patients. Cell differentiation agent-2 (CDA-2) is a persuasive good cancer drug approved by the Chinese FDA. CDA-2 is a preparation of wound healing metabolites purified from urine, which can serve as a model for the development of CDA formulations as good cancer drugs. Wound healing metabolites active as differentiation inducers (DIs) and differentiation helper inducers (DHIs) are the active players of chemo-surveillance created by the nature as allosteric regulators of abnormal methylation enzymes (MEs). The elimination of abnormal MEs is very critical to the success of cancer therapy. Wound healing is a simple matter that comes naturally, because the nature creates chemo-surveillance to ensure perfection of wound healing. Cancer is the consequence of wound unhealing due to the collapse of chemo-surveillance. Cancer therapy can also be a simple matter, if the therapy follows wound healing process. PSCs and CSCs are cells with abnormal MEs, which are protected by drug resistance and anti-apoptosis mechanisms. PSCs are the cells involved in wound healing. Efficient induction of terminal differentiation of PSCs is very critical to the success of wound healing. Natural DIs and DHIs are the partners of PSCs and CSCs in wound healing, which can easily access to PSCs and CSCs. If wound is not healed, PSCs are forced to evolve into CSCs and then to progress to faster growing CCs. CCs display a high level of degradative enzymes to generate substrates for the syntheses of macro-molecules to support their faster growth. Natural DIs and DHIs may be rapidly degraded in CCs. A different set of unnatural DIs and DHIs may be necessary to achieve the induction of terminal differentiation of CCs. Thus, two sets of CDA formulations, one CDA-CSC with natural DIs and DHIs, and another CDA-CC with non-natural DIs and DHIs to accomplish induction of terminal differentiation of both CSCs and CCs to achieve effective therapy of cancer.

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Section: Good Cancer Drugs Vs Bad Cancer Drugsmentioning

confidence: 99%

Section: Development Of Cda Formulations As Good Cancer Drugs To Save...mentioning

confidence: 99%

CDA Formulations as Persuasive Good Cancer Drugs to Save Cancer Patients

Liau,

Craig,

Baker

2024

IJCOCR

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“…We have carried out extensive studies of natural and unnatural DIs and DHIs including the data to achieve ED 25, ED 50 and ED 75 of DIs, and RI 0.5 of DHIs, which is equivalent to ED 25 of DI [4,22,28,[35][36][37][38][61][62][63]. With the availability of such critical data, it is easy to design CDA formulations according to the formula previously described [36].…”

Section: War On Cancermentioning

confidence: 99%

CDA Formulations to Fulfill Cancer Moonshot and to Win the War on Cancer

Liau¹,

Craig²,

Baker³

2023

Int J Res Oncol

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The objective of this study is to call for approval of cell differentiation agent (CDA) formulations as the right cancer drugs to save cancer patients. Moonshot was a presidential project to set a classic record of success attributable to the right approach and war on cancer was another presidential project to set a classic record of failure attributable to the wrong approach. Cancer moonshot was brought up by President Biden to urge health profession to rely on right approaches to save cancer patients. Perpetual replication of cancer cells (CCs) is the most outstanding feature of cancer. Naturally, killing of replicating CCs becomes the top choice of cancer establishments to combat cancer. Killing of CCs is actually a wrong approach of cancer therapy, because cancer is caused by wound unhealing due to the collapse of chemo-surveillance, which is a natural mechanism to ensure perfection of wound healing. Killing of CCs by cytotoxic agents promotes cancer stem cells (CSCs) to proliferate in order to repair the damages created by cytotoxic agents, eventually pushing CSCs to reach a high proportion to become unresponsive to further treatments. Killing of CCs is a wrong approach that causes the failure of cancer solution. To save cancer patients, we have to drastically change past practices. Apparently, wound healing process is the right approach of cancer therapy. Induction of terminal differentiation of PSCs is the most critical mechanism of wound healing, which is achieved by differentiation inducers (DIs) and differentiation helper inducers (DHIs). CDA is a collective term of the preparations consisting of different proportions of DIs and DHIs. Therefore, CDA formulations are the best solution of cancer to fulfill cancer moonshot and to win the war on cancer. CDA formulations display the features as pro-wound healing that can eliminate both CSCs and CCs by inducing these cells to undergo terminal differentiation, and to restore the functionality of chemo-surveillance, which is the creation of the nature to prevent the buildup of cells with abnormal MEs. A perfect cancer drug must have the ability to eliminate both CSCs and CCs, and to restore the functionality of chemo-surveillance. CDA formulations fit the description as perfect cancer drugs to fulfill cancer moonshot and to win the war on cancer.

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“…It is obvious, the right approach of cancer therapy should be the efficient differentiation of PSCs, CSCs, and CCs to eliminate the symptom caused by the wound. Destabilization of abnormal MEs is, therefore, the most appropriate modality of cancer therapy [4,5,14,[16][17][18][19]21,[29][30][31]. Cancer therapy based on destabilization of abnormal MEs displays the features as pro-wound healing and the right indication of cancer therapy, whereas cancer therapies based on killing of CCs display the features exactly opposite as anti-wound healing and contra-indication of cancer therapy, which are not the right approach of cancer therapy.…”

Section: Cancer Arises As a Consequence Of Wound Not Healing Properlymentioning

confidence: 99%

Cancer Moonshot: Moonshot as a Magic Code to Guide Successful Solutions of Tough Challenges Such as Cancer

Liau¹,

Fruehauf²

2023

Int J Res Oncol

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Presidential projects deal with monumentally important issues. Moonshot and war on cancer were two unrelated presidential projects: the moonshot project was successful, but the war on cancer project was unsuccessful. President Biden brought up these two presidential projects on Sept. 12, 2022 apparently with an intention to urge the health profession to learn from the success of moonshot to come up solutions to save 50% of cancer patients in the following 25 years. The goal of cancer moonshot was modest. The health profession, however, must make a drastic change on the approach of cancer therapy to fulfill cancer moonshot. Moonshot was an extremely difficult challenge. So far, the USA was the only nation able to achieve this difficult challenge. Evidently, the right approach to a difficult challenge was the magic code to the success of moonshot. On the other hand, a wrong approach to a simple matter might result in making simple problem unsolvable. Apparently, war on cancer was such a case. Cytotoxic chemotherapy and radiotherapy based on the killing of cancer cells were the choice of cancer establishments to wage the war on cancer. The approach was wrong, because cancer was a disease due to wound unhealing. Creating more wounds definitely was a wrong approach. The war on cancer was loomed to fail on the day of its declaration. The wrong approach continued to dominate cancer therapies with no hope in sight to successfully saving cancer patients. Cancer moonshot was in essence a protest of the failure to save cancer patients from the highest government official to the health profession. A change of approach on cancer therapy is obviously needed to save cancer patients. Since cancer is caused by wound unhealing. Wound healing process is the most appropriate modality of cancer therapy. Wound healing comes naturally, because the nature creates chemo-surveillance to ensure perfection of wound healing. Wound healing requires the proliferation and the terminal differentiation of progenitor stem cells (PSCs). The success of wound healing depends on the efficient differentiation of PSCs to eliminate the symptom created by the wound. Chemo-surveillance plays such an important role to dictate the success of wound healing. Chemo-surveillance can be damaged under pathological conditions to produce tumor necrosis factor (TNF) to cause cachexia symptoms. Inability of PSCs to undergo terminal differentiation due to the collapse of chemo-surveillance then forces PSCs to evolve into cancer stem cells (CSCs) and then to progress to faster growing cancer cells (CCs). Obviously, cancer arises due to the collapse of chemo-surveillance. Restoration of chemo-surveillance with CDA formulations is, therefore, the right approach of cancer therapy. The wisdom of the nature beats the wisdom of cancer establishments on the issue of cancer.

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Winning Formulas to Fulfill Cancer Moonshot

Cited by 4 publications

References 20 publications

CDA Formulations as Persuasive Good Cancer Drugs to Save Cancer Patients

CDA Formulations as Persuasive Good Cancer Drugs to Save Cancer Patients

CDA Formulations to Fulfill Cancer Moonshot and to Win the War on Cancer

Cancer Moonshot: Moonshot as a Magic Code to Guide Successful Solutions of Tough Challenges Such as Cancer

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