Winter Birth in Association with a Risk of Brain Tumor among a Finnish Patient Population

Mainio, Arja; Hakko, Helinä; Koivukangas, John; Niemelä, Asko; Räsänen, Pirkko

doi:10.1159/000094578

Cited by 25 publications

(21 citation statements)

References 31 publications

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“…Our results support previous findings of medulloblastoma having a seasonal peak [6,15,16] . We found seasonal variation with peak months in fall, and we also found that the variation was most significant in older children aged 5-19, in females, and in metropolitan counties.…”

Section: Discussionsupporting

confidence: 93%

“…A study from Norway reported an increased relative risk for all childhood brain tumors, as well as for medulloblastoma, for children born in the winter or fall [6] . A small (n = 101) Finnish study Edwards found that when comparing births in winter (December to February) to births in other seasons, a 1.39-fold excess of winter births among primary brain tumor patients was observed compared to respective births in the general population [16] . A US study which analyzed four different datasets found that cases in the two North Carolina datasets had an increase in fall births (September to November) in those aged 0-19 years, while those in the Los Angeles/San Jose/Monterey, California SEER dataset did not show a significant difference and neither did cases from the national SEER dataset [7] .…”

Section: Discussionmentioning

confidence: 96%

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Seasonal Variation in Incidence of Pediatric Medulloblastoma in the United States, 1995–2001

et al. 2007

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Background/Aims: Brain tumors are the second most common pediatric malignancy. The literature suggests that one of the most common subtypes of malignant childhood brain tumor, medulloblastoma, has some seasonal variation in incidence by month of birth. Methods: Data from cases in the Central Brain Tumor Registry of the United States, including primary brain tumor cases diagnosed in children (0–19 years) between the years 1995 and 2001 from 13 state cancer registries, were analyzed to determine whether there was seasonal variation. Analyses were performed using Edwards’ test for sinusoidal variation, which uses case frequencies per month, and tests whether frequencies follow a sine function over 12 months. Results: Seasonal variation in incidence by month of birth was highly statistically significant for medulloblastoma, not otherwise specified (NOS) (p = 0.016), with the peak occurring in October. Medulloblastoma, NOS also demonstrated seasonal variation in incidence by month of birth in children aged 5–19 (p = 0.041), especially females aged 5–19 (p = 0.034), with the peak in October. There were no significant results for brain tumors overall, or for the other most common pediatric tumor subtypes (pilocytic astrocytoma, other astrocytoma, and ependymoma). Conclusion: These preliminary results indicate seasonal variation unique to medulloblastoma incidence by month of birth and may provide evidence for an environmental exposure etiology, though further studies are needed to explore specific hypotheses.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Seasonal Variation in Incidence of Pediatric Medulloblastoma in the United States, 1995–2001

et al. 2007

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“…Vitamin D can be obtained from sun-exposure and through diets. However, exposure to sunlight, i.e., ultraviolet b (UVB), is the main source of vitamin D in humans, about 90% of all intake, is ultraviolet radiation-induced synthesis in the skin after sun exposure (Poskitt et al, 1979;Vik et al, 1980;Mainio et al, 2006;Hakko et al, 2009). Solar ultraviolet radiation is related to vitamin D status by cutaneous production of vitamin D3 in cancer RESEARCH ARTICLE…”

Section: Introductionmentioning

confidence: 99%

Recurrence Season Impacts the Survival of Epithelial Ovarian Cancer Patients

Liu

Man²,

Wu³

2014

Asian Pacific Journal of Cancer Prevention

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“…In a study, it was reported that winter birth is related to risk of brain tumor among Finnish patients with brain tumors (Mainio et al, 2006). Similarly, it was found the association between birth in January-February and risk of GBM (Brenner et al, 2004).…”

Section: Discussionmentioning

confidence: 90%

Lack of Sunlight Exposure Influence on Primary Glioblastoma Survival

Mutlu

Akca²,

Erden³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The prognosis of primary glioblastoma (GBM) is poor. Approximately 2/3 of primary brain tumor diagnoses are GBM, of which 95% are primary lesions. In this study, we aimed to evaluate whether more sunlight exposure has an effect on survival of patients with primary GBM. Materials and Methods: A total of 111 patients with primary GBM were enrolled from Kayseri in inner Anatolia which has a cold climate (n: 40) and Mersin in Mediterranean region with a warm climate and more sunlight exposure (n: 71). The patients with primary GBM were divided into two groups as Kayseri and Mersin and compared for progression free survival (PFS) and overall survival (OS).Results: The PFS values were 7.0 and 4.7 months for Kayseri and Mersin groups, respectively (p=0.10) and the repsective OS values were 13.3 and 9.4 months (p=0.13). We did not found any significant difference regarding age, sex, comorbidity, smoking, surgery, resurgery, adjuvant chemoradiotherapy and palliative chemotherapy between the groups. Conclusions: We found that more sunlight exposure had no impact on prognosis of patients with primary GBM, adding inconsistency to the literature about the relationship between sunlight and GBM.

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Winter Birth in Association with a Risk of Brain Tumor among a Finnish Patient Population

Cited by 25 publications

References 31 publications

Seasonal Variation in Incidence of Pediatric Medulloblastoma in the United States, 1995–2001

Seasonal Variation in Incidence of Pediatric Medulloblastoma in the United States, 1995–2001

Recurrence Season Impacts the Survival of Epithelial Ovarian Cancer Patients

Lack of Sunlight Exposure Influence on Primary Glioblastoma Survival

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