Winter dysentery: a coronavirus-like agent in the faeces of beef and dairy cattle with diarrhoea

Espinasse, J.; Viso, Michel; Laval, A.; Savey, M.; Layec, Cl. Le; Blot, J. P.; L'Haridon, R.; Cohen, Jon

doi:10.1136/vr.110.16.385

Cited by 22 publications

(21 citation statements)

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“…Outbreaks of acute diarrhoea in adult cattle during the winter season have been reported from a number of countries (Campbell & Cookingham, 1978;Durham et al, 1989;Espinasse et al, 1982;Saif et aL, 1988;Takahashi et al, 1980), the disease often being referred to as winter dysentery. Classically, the clinical syndrome is characterized by an acute onset of dark, bloody, liquid diarrhoea in adult cows, accompanied by decreased milk production and variable depression and anorexia.…”

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confidence: 99%

Comparison of bovine coronavirus isolates associated with neonatal calf diarrhoea and winter dysentery in adult dairy cattle in Quebec

Dea¹,

Michaud²,

Milane³

1995

Journal of General Virology

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Cytopathic coronaviruses were isolated in HRT-18 cells from bloody faecal samples collected from cows in Qurbec dairy herds having experienced typical outbreaks of winter dysentery (WD). The formation of polykaryons in the infected cell cultures was found to be dependent on the presence of trypsin in the medium. The WD isolates differed from the prototype Mebus strain of bovine enteropathogenic coronavirus (BCV.Meb) in respect to haemagglutination inhibition (HI), haemagglutination patterns at 4 °C and 37 °C, and receptor destroying enzyme activity with rat erythrocytes. Other field strains of BCV associated with outbreaks of neonatal calf diarrhoea (NCD) also differed from the BCV.Meb strain by demonstrating differences in HI. In all cases, no differences were detected by virus neutralization and Western immunoblotting. Analysis and comparison of the nucleotide and deduced amino acid sequences of the PCR-amplified haemagglutinin esterase (HE) genes of one representative WD strain (BCQ.2590) and two highly cytopathic NCD strains (BCQ.3 and BCQ.571) revealed high degrees of similarities (nt and aa sequence homologies > 98 %) with the BCV.Meb strain. The putative esterase active site FGDS was conserved among these four BCV strains, indicating that this domain is probably not a determinant for BCV virulence. Six amino acid substitutions occurred between the HE glycoproteins of BCV.Meb and BCQ.2590 strains; two proline substitutions occurred respectively in the signal peptide (at aa 5) and near the sequences of the putative esterase domain (at aa 53).

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confidence: 99%

Comparison of bovine coronavirus isolates associated with neonatal calf diarrhoea and winter dysentery in adult dairy cattle in Quebec

Dea¹,

Michaud²,

Milane³

1995

Journal of General Virology

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“…6 It is most commonly seen in adult dairy cattle, with affected herds having a dramatic decrease in milk production [7][8][9] ; however, WD also has been less frequently observed in adult beef cattle. 10 To our knowledge, the results reported here are the first report of a coronavirus associated with WD in feedlot cattle. Bovine coronavirus was the only enteric pathogen detected in the feedlot cattle in herds 2 and 3.…”

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confidence: 51%

“…The clinical manifestation in the 3 groups of feedlot cattle mimics manifestations described in adult dairy and beef cows with WD. 7,8,[10][11][12][13][14][15][16][17] The consensus from those studies is that coronaviruses are commonly isolated from clinically typical cases of WD. 3,12 Analysis of the IEM, ELISA, and immunofluorescence results also indicated that the coronaviruses detected were antigenically related to the Mebus BCV, similar to earlier reports.…”

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confidence: 99%

Detection and isolation of coronavirus from feces of three herds of feedlot cattle during outbreaks of winter dysentery-like disease

Cho¹,

Halbur²,

Bruna³

et al. 2000

javma

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Clinical signs of a winter dysentery-like syndrome in 6- to 9-month-old cattle in 3 feedlots included acute onset of diarrhea with high morbidity and low mortality, respiratory tract problems that included dyspnea, coughing, and nasal discharge, and high rectal temperatures. Bovine coronavirus was detected by use of an ELISA and immune electron microscopy in fecal and nasal swab samples and by immunohistochemical analysis of intestinal sections collected from calves during necropsy. Bovine coronavirus should be considered in the differential diagnoses for diseases that cause acute onset of bloody diarrhea in feedlot cattle.

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“…A doença afeta principalmente gado leiteiro (Roberts 1957, Campbell & Cookingham 1978, Van Kruiningen et al 1985, Saif et al 1988, Saif, 1990, Saif et al 1991, Travén et al 1993, Natsuaki et al 2007), mas também já foi descrita em gado de corte manejado a campo (Espinasse et al 1982) ou em confinamentos (Cho et al 2000).…”

Section: Introductionunclassified

“…Desde a década de 70 vários trabalhos vêm apontando o envolvimento do coronavírus bovino (BCoV) nos surtos de disenteria de inverno pela detecção do vírus nas fezes de animais enfermos e/ou pelo acompanhamento da soroconversão dos animais durante os surtos (Horner et al 1975, Takahashi et al 1980, Espinasse et al 1982, Van Kruiningen et al 1987, Saif et al 1988, 1991.…”

Section: Introductionunclassified

Achados clínico patológicos durante um surto de disenteria de inverno em bovinos no Rio Grande do Sul

et al. 2008

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Descreve-se um surto de disenteria de inverno que afetou 10 vacas leiteiras de uma propriedade localizada em Viamão, Rio Grande do Sul. O quadro clínico caracterizou-se por uma diarréia inicialmente líquida esverdeada com estrias de sangue e muco, evoluindo, em alguns animais, para uma diarréia de coloração marrom escura à sanguinolenta, que persistiu, em média, cinco dias. Drástica diminuição na produção de leite e no consumo de alimentos, além de graus variados de depressão também foram observados. Apenas um dos 10 animais afetados morreu. Durante a necropsia, observaram-se mucosas pálidas, conteúdo sanguinolento com presença de grande quantidade de coágulos, principalmente no cólon espiral e petéquias na mucosa do cólon. Os principais achados histológicos foram encontradas no cólon espiral, onde havia criptas dilatadas, sem epitélio de revestimento ou revestidas por epitélio pavimentoso e/ou cuboidal, por vezes com núcleos grandes e nucléolos proeminentes. Algumas criptas eram preenchidas por debris necróticos e polimorfonucleares. Na imuno-histoquímica com anticorpo monoclonal para coronavírus bovino (8F2) em cortes do cólon espiral, havia marcações positivas no citoplasma de enterócitos das criptas, nos debris necróticos destas e em macrófagos na lâmina própria.

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Winter dysentery: a coronavirus-like agent in the faeces of beef and dairy cattle with diarrhoea

Cited by 22 publications

References 0 publications

Comparison of bovine coronavirus isolates associated with neonatal calf diarrhoea and winter dysentery in adult dairy cattle in Quebec

Comparison of bovine coronavirus isolates associated with neonatal calf diarrhoea and winter dysentery in adult dairy cattle in Quebec

Detection and isolation of coronavirus from feces of three herds of feedlot cattle during outbreaks of winter dysentery-like disease

Achados clínico patológicos durante um surto de disenteria de inverno em bovinos no Rio Grande do Sul

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