Background. Enzymomycotic depletion of grain leads to a significant decrease in the dry matter mass of the grain, as the intensity of respiration increases, protein substances break down, enzymes (in particular, α-amylase) pass from the adsorbed form to the water-soluble one, and their activity increases sharply. One of the consequences of this is the intensive amylolysis of starch, which means a significant deterioration in the technological indicators of the quality of grain and seeds. Materials and Methods. This study gives a thorough description of the process of enzymomycotic depletion of grain of soft winter wheat (Triticum aestivum L.), sowing rye (Secale cereale L.), winter triticale (Triticosecale Witt.) depending on abiotic factors and the sources of resistance to ear diseases 4, 8, 12 days after the onset of full ripeness in the conditions of the western forest-steppe of Ukraine (2019–2021). Research methods – general scientific, field, measurement and weight, mathematical and statistical. Results and Discussion. According to the obtained results, the dependence of enzymomycotic depletion of grain on abiotic factors was established. The development of ear diseases depended both on weather factors and on the ecological plasticity of the cultivar. The highest percentage of the distribution of ear sepsoria was observed on the 12th day after the onset of full ripeness: wheat – 3.3 %, rye – 2.4 %, triticale – 1.9 %, fusarium, respectively 2.4 %, 1.9 %, 1 %, 8 %. The loss of dry matter in the weight of 1000 grains depended on the ecotype of the cultivar and the duration of the grain standing time 4, 8, and 12 days after full ripeness. Conclusion. The following cultivars were most resistant to EMDG: Oberih Myronivsky (wheat), Kobza (rye), Obrij Myronivsky (triticale); their base seed production profitability rates being 75.1 %, 116.6 %, and 146.8 %, respectively. The results of the study can be used in the selection of varieties of winter grain crops resistant to enzymomycotic grain depletion for the western forest-steppe and Polissya zones of Ukraine, where breeding work on these crops is not carried out and agricultural producers purchase seeds of new varieties from the originating institutions of the central forest-steppe to introduce them into production.